Made available in DSpace on 2014-12-17T14:16:28Z (GMT). No. of bitstreams: 1 CarolinaMC_DISSERT.pdf: 2312881 bytes, checksum: 468e37b11a049ed173243a8574567f3c (MD5) Previous issue date: 2012-02-10 / All medicine, whether allopathic or homeopathic, must go through strict quality control, which must ratify their characteristics throughout the period of validity. During the time of preparation and storage, solutions of the drugs are in permanent contact with packaging materials that can release undesirable substances to the solution. Several factors may influence the release of packing materials, and factorial design (FD) is a useful tool for analyzing the phenomenon. The aim of this study was the determination of quality parameters for Homeopathic solid (globules) and liquid (drops) dosage forms. It was carried out analysis in homeopathic globules for weight variation, mechanical strength, and moisture content uniformity. For liquid preparations, standard solutions were prepared from natural rubber bulbs, which were subjected to exhaustive extraction with two ethanol solutions (30 and 70%) in the ultrasonic bath for 20 minutes at 25?C and 50?C in three successive cycles. Studies of transfer have been made within five days, by spectrophotometric analysis in the UV region at 312 nm with λm?x and 323 nm for samples in 70% ethanol and 30% respectively. PH values were analyzed. We also conducted two FD studies, where the first, the three-level variables were solvent (chloroform, ethanol and nhexane), sample mass (30, 60 and 90mg), particle size (large disk, small disk and powder sample). In the second study, the solvent level variables were different ethanolic degrees (EtOH 30%, 70% and pure). The percentage of lending in the solutions was 5.5%, 12.4%, 24.2% and 41% of the total estimated in the reference solution. The values of rate constants of transfer were determined in the order of 0.0134 days-1 and 0.0232 days-1 in absorbance values, the solutions in ethanol at 30% and 70% respectively. These results suggest that the speed of transfer of materials from rubber is affected both by the nature of the vehicle as by the temperature / Todo medicamento, quer seja alop?tico ou homeop?tico, deve passar por rigoroso controle de qualidade, o qual deve ratificar as suas caracter?sticas ao longo de todo o per?odo de validade. Durante o tempo de preparo e armazenamento, as solu??es dos medicamentos est?o em contato permanente com os materiais de embalagem que podem liberar subst?ncias indesej?veis para a solu??o. V?rios fatores podem influenciar a libera??o de materiais da embalagem, e planejamento fatorial (PF) ? uma ferramenta ?til para analisar o fen?meno. O objetivo deste trabalho foi a determina??o de par?metros de qualidade para Formas Farmac?uticas Homeop?ticas s?lidas (gl?bulos) e liquidas (gotas). Foi efetuada a avalia??o dos gl?obulos homeop?ticos no que diz respeito ? sua varia??o de peso, testes de resist?ncia mec?nica, uniformidade de conte?do e umidade. Para as prepara??es liquidas, preparamos solu??es de refer?ncia a partir de bulbos de borracha natural, os quais foram submetidos ? extra??o exaustiva com duas solu??es de etanol (30 e 70%), em banho de ultrassom durante 20 minutos a 25?C e 50?C, em tr?s ciclos sucessivos de 24 horas. Os estudos de ced?ncia foram efetuados num tempo de cinco dias, atrav?s de an?lise espectrofotom?trica na regi?o UV com λm?x em 312 nm e 323 nm para as amostras em etanol a 70% e 30%, respectivamente. Foram verificados valores de pH. Foram tamb?m realizados dois estudos de PF, onde no primeiro, as tr?s vari?veis de n?vel foram solvente (clorof?rmio, etanol e n-hexano), massa de amostra (30, 60 e 90mg), a forma de amostra (grande disco, disco pequeno, a amostra em p?). No segundo estudo, as vari?veis de n?vel solvente foram gradua??es etan?licas diferentes (EtOH 30%, 70% e puro). O percentual de ced?ncia nas solu??es foi de 5,5%, 12,4%, 24,2% e 41% do total estimado na solu??o de refer?ncia. Os valores das constantes de velocidade de ced?ncia foram determinados na ordem de 0,0134 dia-1 e 0,0232 dia-1, em valores de absorb?ncia, nas solu??es em etanol a 30% e 70%, respectivamente. Esses resultados sugerem que a velocidade de ced?ncia de materiais a partir da borracha ? afetada tanto pela natureza do ve?culo como pela temperatura