Global ETD Search

1	HoxA11 DOWNSTREAM TARGETS IN KIDNEY DEVELOPMENT FENG, YUXIN 11 October 2001 (has links) No description available. Biology, Molecular HoxA11 kidney development gene chip engrailed repressor downstream targets
2	Využití testu CAM pro charakterizaci a studium invazivních vlastností rakovinných buněk / The use of CAM assay for characterization and study of cancer cell invasive properties Vágnerová, Lenka January 2011 (has links) The chorioallantoic membrane (CAM) of chicken embryos belongs to the in vivo model systems frequently used for the study of angiogenesis and cell invasiveness. Using CAM assay we have tested selected chicken sarcoma cell lines characterized by different angiogenic properties and different ability to form metastasis. In addition to CAM assay, several other methods have been used to characterize the phenotype of these cell lines. We have selected a few proteins which could significantly influence the angiogenic and metastatic properties of investigated cell lines. We have established cell lines stably overexpressing these genes and compared their phenotypes with parental cell lines. We have shown that genes encoding ISL1, ARNT2, PROM1, HOXA11 proteins participate, in our experimental model, in activation of programes controlling angiogenesis and cell invasion.
3	Regulation of the Timing of Puberty: Exploration of the Role of Epigenetics Rzeczkowska, Paulina Agnieszka 16 August 2012 (has links) Pubertal timing displays wide, normally distributed variation in a healthy population of sexually maturing adolescents. However, like many complex traits, factors contributing to the variation are not well understood. Epigenetic regulation may contribute to some of the population variation. The role that epigenetics, specifically DNA methylation and histone acetylation, may play in regulating pubertal timing was investigated in C57BL/6 female mice: investigating whether population variation in pubertal timing among inbred mice could be explained by environmental factors; whether perturbing the epigenome using a histone deacetylase inhibitor or methyl-donor would alter pubertal timing; and examining genome-wide methylation patterns in hypothalami of early versus late maturing mice. Results demonstrate that measurable micro-environmental factors have only negligible effects on pubertal timing; pubertal timing was significantly altered by administration of epigenetic modifying agents; differences in methylation patterns are subtle. This initial evidence supports the involvement of epigenetic mechanisms in regulating pubertal timing. puberty epigenetics DNA methylation histone acetylation C57BL/6 female mice histone deacetylase inhibitor methyl-donor microarray growth Hoxa11 variation in complex traits epigenome wide association study L-methioine suberoylanilide hydroxamic acid 0369
4	Regulation of the Timing of Puberty: Exploration of the Role of Epigenetics Rzeczkowska, Paulina Agnieszka 16 August 2012 (has links) Pubertal timing displays wide, normally distributed variation in a healthy population of sexually maturing adolescents. However, like many complex traits, factors contributing to the variation are not well understood. Epigenetic regulation may contribute to some of the population variation. The role that epigenetics, specifically DNA methylation and histone acetylation, may play in regulating pubertal timing was investigated in C57BL/6 female mice: investigating whether population variation in pubertal timing among inbred mice could be explained by environmental factors; whether perturbing the epigenome using a histone deacetylase inhibitor or methyl-donor would alter pubertal timing; and examining genome-wide methylation patterns in hypothalami of early versus late maturing mice. Results demonstrate that measurable micro-environmental factors have only negligible effects on pubertal timing; pubertal timing was significantly altered by administration of epigenetic modifying agents; differences in methylation patterns are subtle. This initial evidence supports the involvement of epigenetic mechanisms in regulating pubertal timing. puberty epigenetics DNA methylation histone acetylation C57BL/6 female mice histone deacetylase inhibitor methyl-donor microarray growth Hoxa11 variation in complex traits epigenome wide association study L-methioine suberoylanilide hydroxamic acid 0369

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