Project Completion Report, OWRT Project No. A-051-ARIZ / Agreement No. 14-31-0001-5003 / Project Dates: July 1974 - June 1975 / Acknowledgement: The work upon which this report is based was supported by funds provided by the United States Department of the Interior, Office of Water Research and Technology, as authorized under the Water Resources Research Act of 1978. / Bio-physicochemical measurements were made on treated sewage effluent releases at established locations within the channel of an ephemeral stream, the Santa Cruz River of Southern Arizona. Water samples were taken in chronological sequence as the effluent moved downstream, to trace changes in quality parameters during low and high hydrograph stages. Results indicate that dissolved oxygen (DO) concentrations at low effluent flows were higher than DO concentrations at high effluent flows; while, conversely, biochemical oxygen demand (BOD) concentrations at low effluent flows were generally lower than BOD concentrations at high effluent flows. Biochemical oxygen demand concentrations are affected by waste loadings, flow conditions, phytoplankton growth and nitrification. Mean river deoxygenation rates (k ) in sewage flows after six river miles from the Tucson Sewage Treatment Plant were always negative or increasing, indicative of nitrification, algal growth, and concentration of organic constituents through seepage losses.