程雅芳, Chan, Ya-fong, Betty.
published_or_final_version / Physiology / Master / Master of Science
Wang, Ying-ping, 王寅丙
published_or_final_version / Physiology / Master / Master of Philosophy
Hypotensive and renal physiological effects of an extract from phoenix mushroom, Pleurotus sajor-caju.January 1986 (has links)
by Kay-Pong Yip. / Thesis (M.Ph.)--Chinese University of Hong Kong, 1986. / Bibliography: leaves 77-89
Development and in vivo testing of novel hydrochlorothiazide gastric retention formulations in healthy volunteers and stage I hypertensive patientsFarid, Samar Farghali 06 May 2004 (has links)
This thesis describes in vitro and in vivo evaluation of a gastric retention formulation (GRF) developed at Oregon State University. The formulation was prepared from xanthan gum and locust bean gum as gelling agents and other formulation ingredients were added, then it was originally vacuum oven dried. The effect of freeze drying on GRF was studied in this research. Freeze dried GRF were evaluated for dissolution and drug release properties using hydrochlorothiazide as a model drug. The effect of storage of GRF inside hard gelatin capsules on rate of swelling of the capsule shell and release of GRF was also studied. Storage for up to 12 months had no effect on capsule shell swelling and release of GRF. Gastric residence time, pharmacokinetics and bioavailability of hydrochlorothiazide, a drug that has an absorption window limited to the upper small intestine, from two different sizes of gastric retention formulations (GRF) were evaluated in 12 healthy volunteers in both fed and fasted states, and compared to immediate release tablets. Extent of bioavailability of drug from the larger formulation in this study was comparable to IR tablets in both fed and fasted states. Deconvolved input functions data suggest that the GRF stayed in the stomach providing sustained drug input for 12-28 hours. Initial blood pressure lowering and side effects of hydrochlorothiazide from a gastric retention formulation were evaluated and compared to immediate release tablets in 10 subjects with stage I hypertension. Gastric retention formulations produced an average reduction in systolic blood pressure 3 mm Hg lower than IR tablets regardless of sequence of administration. GRF also produced less blood pressure fluctuation in most subjects than IR tablets. Most subjects reported fewer and less severe side effects with GRF than IR tablets. / Graduation date: 2004
Studies on the mechanism of the hypotensive action of Huang chin : (Scutellaria baicalensis Georgi).Wang, Ying-ping, January 1974 (has links)
Thesis--M. Phil., University of Hong Kong.
Chan, Ya-fong, Betty.
Thesis (M. Sc.)--University of Hong Kong, 1969. / Typewritten.
28 August 2008
Not available / text
Read, George Wesley
Typescript. / Bibliography: leaves 80-90. / viii, 90 l illus
Vincze, Gábor, Barner, Jamie C.,
(has links) (PDF)
Thesis (Ph. D.)--University of Texas at Austin, 2004. / Supervisor: Jamie C. Barner. Vita. Includes bibliographical references.
An audit on anti-hypertensive drug management amongst general out-patient clinics in New Territories West regionKung, Kin-hang. January 2004 (has links)
Thesis (M.Med.Sc.)--University of Hong Kong, 2004. / Also available in print.
Page generated in 0.1085 seconds