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There is a grave concern for the life, liberty and security of individuals who have been forced to leave their homes and have become dispersed within their native countries and throughout the Asian continent. These internally displaced persons and refugees are the subject of this study. Some of the themes that will be discussed include: civil war, human rights violations and the economy, since these are the problems affecting the populations of Afghanistan, Pakistan and Myanmar. These case studies are of particular interest because Afghanistan is where most refugees come from, Myanmar has the longest-running military regime and Pakistan hosts the most refugees in the world. All three case studies are currently in a state of civil war, are breeding grounds for violations of human rights and have corrupt economies. Thus, the goal is to end armed conflict, to put an end to the human rights violations that come with it and to restructure the economies in each of these nation states so that the internally displaced persons and refugees can be repatriated, since displacement has become too much of a burden for Afghanistan, Pakistan and Myanmar's neighboring countries, who have been taking in all of the refugees from said countries. Theoretically, if the issues causing displacement were to be solved, then the countries that host refugees would be able to concentrate on their own populations. This study can potentially address the gap between knowledge, policy formation, and policy implementation to realize the goals of the international community in dealing with the displacement crisis.

Since 2006 Swedish compulsory school teachers are required to use individual developmentplans (IDPs) as part of their assessment practices. The IDP has developed through two major reforms and is currently about to undergo a third in which requirements for documentation are to be reduced. The original purpose of IDP was formative: a document containing targets and strategies for the student's future learning was to be drawn up at the parent-pupil-teacher meetingeach semester. The 2008 reform added requirements for written summative assessments/grade-like symbols to be used in the plan. This thesis aims to generate knowledge of the IDP as a tool in terms of what characterizes IDP documents as well as teachers' descriptions of continuous IDP work. It contains four articles. The first two are based on 379 collected IDP documents from all stages of compulsoryschool, and the last two build on interviews with 15 teachers. Throughout, qualitative content analysis has been used for processing data. The analytical framework comprises Latour's conceptual pair inscription – translation, Wartofsky's notions of primary/secondary/tertiary artifacts, and Wertsch's distinction between mastery and appropriation, which together provide an overall framework for understanding how the IDP becomes a contextually shaped tool that mediates teachers' actions in practice. Moreover, the activity theoretical concept of contradictionis used to understand and discuss dilemmas teachers experience in relation to IDP. In article 1, targets and strategies for future learning given to students are investigated and discussed in relation to definitions of formative assessment. Concepts were derived from the data and used for creating a typology of target and strategy types related either to being aspects (students' behavior/attitudes/personalities) or to subject matter learning. In article 2, the distribution of being and learning targets to boys and girls, respectively, is investigated. The results point to a significant gendered difference in the distribution of being targets. Possible reasons for the gendered distribution are discussed from a doing-gender perspective, and the proportion of being targets in IDPs is discussed from an assessment validity point of view. In article 3, teachers' continuous work with IDPs is explored, and it is suggested that IDP work develops in relation to perceived purposes and the contextual conditions framing teachers' work. Three qualitatively different ways of perceiving and working with IDP are described in a typology. Article 4 elaborates on dilemmas that teachers experience in relation to IDP, concerning time, communication, and assessment. A tentative categorization of dilemma management strategies is also presented. Results are synthesized in the final part of the thesis, where the ways in which documents are written and IDP work is carried out are discussed as being shaped in the intersection between rules and guidelines at national, municipal and local school level, and companies creating solutions for IDP documentation. Various purposes are to be achieved with the help of the IDP, which makes it a potential field of tension that is not always easy for teachers to navigate. Several IDP-related difficulties, but also opportunities and affordances, are visualized in the studies of this thesis. / <p>Svensk sammanfattning: s. 111-126.</p>

ErbB2/HER2 est un récepteur tyrosine kinase de la famille d'EGFR (ErbB1) surexprimé dans plus de 20% des cancers du sein et associé à une forme particulièrement agressive de la maladie. Les récepteurs ErbBs sont actifs seulement sous forme de dimères, permettant la phosphorylation de leur queue C-terminale par leur domaine tyrosine kinase. La phosphorylation entraine l'interaction avec des protéines adaptatrices et l'activation de voies de signalisation, Ras/MAPK et PI3K/Akt principalement. Ces voies contrôlent la prolifération, la motilité cellulaire et la résistance à l'apoptose. Contrairement à ErbB1/3/4, ErbB2 dimérise en l'absence de ligand. Comprendre les autres mécanismes de régulation de la phosphorylation de ses tyrosines et de ses interactions est donc particulièrement intéressant.ErbB2 a fait l'objet de nombreuses études structurales et fonctionnelles. Elles ont permis la mise au point de traitements ciblés efficaces mais sujets à l'apparition de résistance, dont l'anticorps Trastuzumab, ciblant sa partie extracellulaire. La queue C-terminale d'ErbB2 (CtErbB2) a été très souvent ignorée dans ces études. Cette partie étant intrinsèquement désordonnée, il a fallu attendre ces dernières années pour que les concepts et les outils permettant de l'étudier émergent.Dans cette thèse, j'ai d'abord effectué la caractérisation structurale et dynamique de CtErbB2. J'ai montré que bien qu'étant dépourvue de toute structure stable, cette région riche en prolines possède plusieurs structures secondaires transitoires et un contact longue-distance participant très probablement à la régulation de ses interactions intra- et inter-moléculaires. Dans une deuxième partie je me suis intéressée à la caractérisation de la protéine adaptatrice Grb2, partenaire essentiel de ErbB2 pour l'activation de la voie des MAP kinases. L'organisation en solution des domaines de cette protéine modulaire dans sa forme libre était jusque là inconnue. J'ai ensuite étudié l'interaction entre Grb2 et CtErbB2, et montré que CtErbB2 interagit non seulement avec le domaine SH2 de Grb2 (par l'intermédiaire d'une phosphotyrosine), mais aussi avec son domaine SH3 N-terminal (grâce à un motif polyproline). Enfin, j'ai mis en place plusieurs stratégies de phosphorylation des tyrosines de CtErbB2, dans le but d'étudier plus largement l'effet des phosphorylations sur l'ensemble de cette région. / ErbB2/HER2 is a receptor tyrosine kinase of the EGFR (ErbB1) family overexpressed in 20% of breast cancers and associated to a particularly aggressive form of the disease. ErbB receptors are only active upon dimerization that enables phosphorylation of their C-terminal tail by their tyrosine kinase domain. Phosphorylation then triggers interaction with adaptor proteins and activation of signaling pathways, mainly Ras/MAPK and Akt/PI3K. Those pathways control cell proliferation, motility and resistance to apoptosis. Contrary to ErbB1/3/4, ErbB2 can dimerize without any ligand. Understanding other mechanisms of regulation of its tyrosine phosphorylation and of its interactions is thus particularly interesting.ErbB2 structure and function have been extensively studied. This has led to the development of several FDA-approved targeted drugs, that are effective but to which resistance occurs, amongst which the Trastuzumab antibody that targets ErbB2 extracellular domain. The C-terminal tail of ErbB2 (CtErbB2) has been widely ignored in these studies. Since it is intrinsically disordered, the concepts and tools to study it have only emerged in the last few years.In the present work, I have performed the structural and dynamic study of CtErbB2. I showed that despite its lack of any stable structure, this proline-rich region exhibits several transient secondary structures and a long-range contact that might participate in the regulation of its intra- and inter-molecular interactions. Then, I characterized the adaptor protein Grb2, which is a partner of ErbB2 that is essential for the activation of the MAPK pathway. The solution organization of the domains of this modular protein in its apo-form was unknown so far. I also studied the interaction between Grb2 and CtErbB2, showing that in addition to the known SH2-phosphotyrosine interaction, a polyproline motif of CtErbB2 binds to the N-terminal SH3 domain of Grb2. Finally, I implemented several strategies to phosphorylate CtErbB2 tyrosines, to study more extensively the effect of phosphorylation on the whole tail.

My dissertation research was a 14-month ethnographic study of the post-repatriation experience of forced migrants in South Sudan. It was designed to determine if alterations to gender norms and relations that refugees experienced during asylum differed as a function of the asylum environments and if these modifications remained intact upon the refugees’ return. The forced migrants in my sample, the Dinka of Bor from South Sudan, encountered two different asylum environments and experiences: Kakuma refugee camp in northern Kenya and Khartoum, in northern Sudan. After 10-15 years in asylum, these forced Dinka Bor migrants returned to South Sudan. I compared the pre-flight and post-repatriation behavior of these two groups of returnees to determine to what extent gendered behaviors could be attributed to each asylum location. I found that various global forces encountered during asylum were instrumental in forging new ways of life by changing gendered livelihood practices and gendered access to status, power, and resources after return. In addition, the resettlement context played an equally critical role in the gendered behaviors after return.

The dawn of democracy and adoption of the new constitution heralded in a new political dispensation for South Africa. These development set local government in a new path as various pieces of legislations and policies were passed to transform local government from fragmented and racially – based municipalities into democratic and non – racial entities. Transformation did not end on amalgamation of racial municipal entities and change to racial composition of the administration staff but has to transcend beyond to ensure accountability, transparency, responsive and participation of communities in the affairs of local government to promote good governance. The Sedibeng District Municipality (SDM) established various structures, systems and processes intend on promoting transformation. However, its process of transformation is limited only to the structure and composition of the administration. Little was done to transform the reigning culture which has its roots in the apartheid past, despite the existence of policies including the White Paper on the Transforming Public Service Delivery (Batho Pele). Accordingly, the existence of new structures, systems and processes failed to curb corruption in the ranks of Sedibeng District Municipality. Currently, a number of staff members are facing various charges of fraud and corruption. The Auditor – General have found that millions of rands have spent without proper procedure being followed. The state of affairs give indications that existing structures, systems and processes are not solid enough to curb corruption. Furthermore, the situation is accentuated by the municipality’s failure to involve communities in the affairs of the local government. Communities are only used to rubber – stamp processes and programmes that are imposed by the municipality. This renders communities and community organisations useless and ineffective in holding the councillors accountable. Against the background of the problem statement, the hypotheses of the study were formulated as follows: * There is a non – compliance of municipal regulations required for transformation and good governance at Sedibeng District Municipality. * The leadership of the municipality does not possess adequate knowledge and the political will to monitor and ensure consistent adherence to regulations as required by law to promote transformation and good governance. The study utilized both qualitative and quantitative research methods. The study involved a number of techniques to gather information which includes literature study and empirical research. The findings of the study prove that there is a high level non – compliance of municipal regulations required to promote good governance at Sedibeng District Municipality. The responses of senior management also prove that there is a clear lack of leadership in the Sedibeng District Municipality. The study offers significant recommendations to improve the situation. The intend of the study was to explore and open avenue for further research in the field of change management (transformation of behaviour and culture), impact of cadre deployment in municipal performance and idea of public participation and involvement in the affairs of local government. / M Development and Management (Public Management and Governance), North-West University, Vaal Triangle Campus, 2014

This research explores the responses of eleven teachers, drawn from teaching, managerial, policy, and union levels, to their involvement in the development and implementation of Teacher Review and Development (TRAD) and Individual Development Plans (IDP). Through a case study methodology that uses a phenomenological approach, this research found that TRAD and IDP had little credibility as tools of teacher development or appraisal for teachers because of a range of complexities that included the politicisation of the processes, a lack of financial and resource support, and varied quality control measures. The research elicited a list of criteria for successful design and development of appraisal processes. These are detailed in Chapter Five of the thesis. They are rigorous monitoring and modelling of the processes, clear goals with stated end dates and recognition for involvement, appraisal that is integrated in existing work practices and based on shared understandings of work value, the provision of resources and time targeted at the appraisal process, a commitment to identifying and acting on inefficiencies, appraisal that is focused on teacher development and not directly linked to salary "reward". The research concludes that authentic teacher review and development will not take place until teachers themselves take on the responsibility, as a professional group, external to their employer, for the design of teacher review and development.

Before the historical democratic elections of 1994, South Africa did not have a culture of actively engaging communities in local government affairs. Democracy brought emphasis to transparency in municipal activities, and greater public accountability. It is legislated in South Africa that local governments should interact with communities in an endeavour to carry out the responsibilities of service delivery to ensure growth and development in a manner that promotes and enhances community participation and accountability. However, integrated municipal development planning, budgeting, local economic development projects, and various forms of municipal partnerships, are all issues which require effective community participation processes. Local government as a sphere government closest to the people is now expected to engage communities through exploring sustainable strategies as mechanisms which, within the context of this study, bring about effective public participation. In this regard, an effective, efficient, vibrant and innovative local government system that is accountable to local communities is of obvious importance. The local government has a key role to play in ensuring that people receive quality leadership and a sound and stable local democracy. Section 153 of the Constitution of the Republic of South Africa, 1996 (Act 108 of 1996) spells out two important developmental duties of a municipality: * To structure and manage its administration and budget planning process so as to give priority to the basic needs of the community and to promote the environmental and socio-economic development of the community: and * To participate in national and provincial development programmes. The purpose of this study was to determine a variety of effective channels or mechanisms and processes for public participation in the integrated development planning (IDP) and budget process in the Tlokwe Local Municipality. It also focuses on the policy and legislative framework underpinning public participation in the IDP and budget processes. The study further considers that legislation requires that the IDP process of Tlokwe Municipality should structurally incorporate the voice of the community which will be affected by planning. The researcher used a qualitative method to determine how Tlokwe Local Municipality addresses the needs of the local community to enhance participatory democracy. The study established that there are a number of challenges facing the municipality which are barriers to effective participation. Several of these challenges relate to the poor and the marginalised groups which still have far too little influence in the affairs of the municipality. / Thesis (MA (Public Management and Governance))--North-West University, Potchefstroom Campus, 2013

The dawn of democracy and adoption of the new constitution heralded in a new political dispensation for South Africa. These development set local government in a new path as various pieces of legislations and policies were passed to transform local government from fragmented and racially – based municipalities into democratic and non – racial entities. Transformation did not end on amalgamation of racial municipal entities and change to racial composition of the administration staff but has to transcend beyond to ensure accountability, transparency, responsive and participation of communities in the affairs of local government to promote good governance. The Sedibeng District Municipality (SDM) established various structures, systems and processes intend on promoting transformation. However, its process of transformation is limited only to the structure and composition of the administration. Little was done to transform the reigning culture which has its roots in the apartheid past, despite the existence of policies including the White Paper on the Transforming Public Service Delivery (Batho Pele). Accordingly, the existence of new structures, systems and processes failed to curb corruption in the ranks of Sedibeng District Municipality. Currently, a number of staff members are facing various charges of fraud and corruption. The Auditor – General have found that millions of rands have spent without proper procedure being followed. The state of affairs give indications that existing structures, systems and processes are not solid enough to curb corruption. Furthermore, the situation is accentuated by the municipality’s failure to involve communities in the affairs of the local government. Communities are only used to rubber – stamp processes and programmes that are imposed by the municipality. This renders communities and community organisations useless and ineffective in holding the councillors accountable. Against the background of the problem statement, the hypotheses of the study were formulated as follows: * There is a non – compliance of municipal regulations required for transformation and good governance at Sedibeng District Municipality. * The leadership of the municipality does not possess adequate knowledge and the political will to monitor and ensure consistent adherence to regulations as required by law to promote transformation and good governance. The study utilized both qualitative and quantitative research methods. The study involved a number of techniques to gather information which includes literature study and empirical research. The findings of the study prove that there is a high level non – compliance of municipal regulations required to promote good governance at Sedibeng District Municipality. The responses of senior management also prove that there is a clear lack of leadership in the Sedibeng District Municipality. The study offers significant recommendations to improve the situation. The intend of the study was to explore and open avenue for further research in the field of change management (transformation of behaviour and culture), impact of cadre deployment in municipal performance and idea of public participation and involvement in the affairs of local government. / M Development and Management (Public Management and Governance), North-West University, Vaal Triangle Campus, 2014

Before the historical democratic elections of 1994, South Africa did not have a culture of actively engaging communities in local government affairs. Democracy brought emphasis to transparency in municipal activities, and greater public accountability. It is legislated in South Africa that local governments should interact with communities in an endeavour to carry out the responsibilities of service delivery to ensure growth and development in a manner that promotes and enhances community participation and accountability. However, integrated municipal development planning, budgeting, local economic development projects, and various forms of municipal partnerships, are all issues which require effective community participation processes. Local government as a sphere government closest to the people is now expected to engage communities through exploring sustainable strategies as mechanisms which, within the context of this study, bring about effective public participation. In this regard, an effective, efficient, vibrant and innovative local government system that is accountable to local communities is of obvious importance. The local government has a key role to play in ensuring that people receive quality leadership and a sound and stable local democracy. Section 153 of the Constitution of the Republic of South Africa, 1996 (Act 108 of 1996) spells out two important developmental duties of a municipality: * To structure and manage its administration and budget planning process so as to give priority to the basic needs of the community and to promote the environmental and socio-economic development of the community: and * To participate in national and provincial development programmes. The purpose of this study was to determine a variety of effective channels or mechanisms and processes for public participation in the integrated development planning (IDP) and budget process in the Tlokwe Local Municipality. It also focuses on the policy and legislative framework underpinning public participation in the IDP and budget processes. The study further considers that legislation requires that the IDP process of Tlokwe Municipality should structurally incorporate the voice of the community which will be affected by planning. The researcher used a qualitative method to determine how Tlokwe Local Municipality addresses the needs of the local community to enhance participatory democracy. The study established that there are a number of challenges facing the municipality which are barriers to effective participation. Several of these challenges relate to the poor and the marginalised groups which still have far too little influence in the affairs of the municipality. / Thesis (MA (Public Management and Governance))--North-West University, Potchefstroom Campus, 2013