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Construction et caractérisation de mutants immunoréactifs du récepteur AT[indice 1] de l'angiotensine IIRoy, Stéphanie. January 1997 (has links)
Thèses (M.Sc.)--Université de Sherbrooke (Canada), 1997. / Titre de l'écran-titre (visionné le 20 juin 2006). Publié aussi en version papier.
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Die Donorseite des Photosystems II der Pflanzen Rekombinationsfluoreszenz- und Röntgenabsorptionsstudien /Grabolle, Markus. January 2005 (has links)
Berlin, Freie Universiẗat, Diss., 2005. / Dateiformat: zip, Dateien im PDF-Format.
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Der Mangankomplex der Photosynthese im katalytischen Zyklus neue röntgenspektroskopische Ansätze zur Untersuchung von Struktur und Mechanismus /Liebisch, Peter. January 2005 (has links)
Berlin, Freie Universiẗat, Diss., 2005. / Dateiformat: zip, Dateien im PDF-Format.
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Vatican II: of Happy Memories - and Future Hope?Lash, Nicholas Unknown Date (has links)
with Professor Nicholas Lash / Higgins Hall 310
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Sodium-glucose co-transporter 2 mediates angiotensinogen augmentation in renal proximal tubular cells under high glucose conditionsJanuary 2017 (has links)
acase@tulane.edu / Increased activity of the intrarenal renin-angiotensin system (RAS), in which proximal tubular angiotensinogen (AGT) is a key factor, has been implicated in the progression of diabetic nephropathy. AGT expression is upregulated in renal proximal tubular cells (PTC) by high glucose due to elevated reactive oxygen species (ROS) generation. Angiotensin II (Ang II) also promotes ROS generation. Glucose reabsorption in PTC occurs mainly through sodium-glucose co-transporter 2 (SGLT2). This study was performed to demonstrate that SGLT2 mediates AGT augmentation in PTC under hyperglycemic conditions. Furthermore, the enhancing effect of Ang II was investigated. Established mouse PTC were treated with 5 (normal), 15, or 25 mM D-glucose or D-mannitol (osmotic control). Pyruvate was used to investigate the role of glycolysis on AGT regulation. Glycolytic activity was quantified using a Seahorse metabolic analyzer. Tempol, an antioxidant, was used to determine the role of ROS. SGLT2 expression was silenced using shRNA. PTC were treated with high glucose and 10-10-10-7 M Ang II or an Ang II receptor blocker. AGT protein levels were increased by 15 (4.4 ± 0.2-fold over control) and 25 mM (4.6 ± 0.2-fold) glucose. AGT mRNA was also augmented (31.1 ± 3.5-fold) by 25 mM glucose, but not mannitol. AGT expression was stimulated by pyruvate (10.7 ± 1.0-fold over control), and exposure to 10, 15, or 25 mM glucose increased glycolytic activity (3.10 ± 0.28-fold, 2.74 ± 0.20-fold, and 2.75 ± 0.34-fold, respectively), suggesting that enhanced glycolysis stimulates AGT expression. ROS accumulation increased (3.03 ± 0.29-fold) in 25 mM glucose over control. Tempol attenuated glucose-induced AGT augmentation by 77%, suggesting that ROS generation contributes to AGT upregulation. SGLT2 knockdown prevented AGT augmentation in 15 mM glucose, indicating that SGLT2 plays a key role mediating AGT upregulation by high glucose. Ang II receptor blockade did not alter AGT levels, and Ang II did not enhance AGT expression in normal or high glucose. Similarly, SGLT2 expression was unchanged by glucose or Ang II. These results indicate that SGLT2 contributes to AGT upregulation in PTC by high glucose, which helps to explain the mechanisms causing intrarenal RAS activation and consequent diabetic nephropathy. / 1 / Michael W. Cypress
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Caractérisation biochimique du récepteur de type 2 de l'angiotensine II par la méthode du marquage par photoaffinitéServant, Guy. January 1997 (has links)
Thèses (Ph.D.)--Université de Sherbrooke (Canada), 1997. / Titre de l'écran-titre (visionné le 20 juillet 2006). Publié aussi en version papier.
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Caractérisation du site de liaison atypique de l'angiotensine II dans le foie de pouletBouley, Richard. January 1998 (has links)
Thèses (Ph.D.)--Université de Sherbrooke (Canada), 1998. / Titre de l'écran-titre (visionné le 15 août 2006). Publié aussi en version papier.
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Étude conformationnelle de l'angiotensine II et du récepteur AT [indice] 1 humainPérodin, Jacqueline. January 2000 (has links)
Thèses (Ph.D.)--Université de Sherbrooke (Canada), 2000. / Titre de l'écran-titre (visionné le 20 juin 2006). Publié aussi en version papier.
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Caractérisation fonctionelle [i.e. fonctionnelle] du récepteur AT(4) dans les cellules endothéliales d'aorte de boeufBriand, Sandie. January 2002 (has links)
Thèses (Ph.D.)--Université de Sherbrooke (Canada), 2002. / Titre de l'écran-titre (visionné le 15 août 2006). Publié aussi en version papier.
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New peptidic angiotensin II analogues : their synthesis and pharmacological characterizationRihakova, Lenka. January 2001 (has links)
Thèses (Ph.D.)--Université de Sherbrooke (Canada), 2001. / Titre de l'écran-titre (visionné le 20 juin 2006). Publié aussi en version papier.
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