No description available.

A Dissertation submitted to the faculty of Medicine, University of the Witwatersrand, in partial fulfillment of the requirements for the Degree of Master of Medicine in paediatrics. / The aims of this study were to establish the incidence of perinatally and nosocomially acquired bacteraemia and funqaemia as determinad by blood and cerebrospinal fluid (CSF) isolates in the neonatal population seen at the Baraqwanath Neonatal Unit; to identify risk factors for infection and record the outcome. Other aims were to analyze tha susceptibility patterns of the organisms isolated with respect to changing antimicrobial policies and to compare these with previously reported studies. (Abbreviation abstract) / Andrew Chakane 2018

No description available.

Thesis (M.S.)--University of Michigan, 1964.

Thesis (M.S.)--University of Michigan, 1979.

Thesis (M.S.)--University of Michigan, 1964.

Thesis (doctoral)--Freie Universität Berlin, 1979.

Thesis (M.S.)--University of Wisconsin-Madison. / eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references (leaves 93-101).

A dor gera desconforto, estresse e irritabilidade em recÃm-nascidos. Objetivou-se avaliar a dor dos recÃm-nascidos prÃ-termo por meio da escala Neonatal Facial Coding System (NFCS) durante a punÃÃo arterial, no grupo com intervenÃÃo musical e no grupo com intervenÃÃo de glicose 25%. Ensaio clÃnico randomizado transversal, duplo cego, realizado em um hospital pÃblico, em Fortaleza/CearÃ/Brasil. Os dados foram coletados de maio/agosto/2013, com base em levantamento de banco de filmagens de recÃm-nascidos prÃ-termo, assistidos nas unidades de cuidados intensivos e intermediÃrios neonatais, entre novembro/2011 e agosto/2012. A amostra constou de 48 recÃm-nascidos prÃ-termo, 26 randomizados no Grupo Experimental (MÃsica), 22 no Grupo Controle (Glicose 25%). Uma mÃsica de ninar foi tocada durante 10 minutos antes da punÃÃo arterial por meio de MP4 interligado ao fone de ouvido, para os neonatos do Grupo Experimental, sendo 2ml de glicose 25% administrada para os do Grupo Controle dois minutos antes da punÃÃo arterial. Coleta realizada por meio da anÃlise das expressÃes faciais contidas num formulÃrio para caracterizar o Momento PrÃ-IntervenÃÃo (10 minutos anteriores ao Momento de Tratamento, distribuÃdos em oito minutos iniciais e dois minutos finais); e em cinco momentos para o NFCS: Basal (14 segundos), Tratamento (quatro segundos â antissepsia), Doloroso (20 segundos), RecuperaÃÃo 1 (20 segundos â compressÃo) e RecuperaÃÃo 2 (20 segundos â cinco minutos apÃs recuperaÃÃo 1). As expressÃes faciais foram analisadas por quatro especialistas, sendo um no Momento PrÃ-IntervenÃÃo, que mensurou o nÃmero de movimentos do choro, espirro, bocejo, franzir de testa, olhar focalizado, olhar vago, dormindo, movimento da cabeÃa e membros superiores em face e outros trÃs, que avaliaram a mÃmica facial pela NFCS. Pesquisa aprovada por comità de Ãtica sob o parecer n 060717/11. A ANOVA mostrou que, no Momento PrÃ-IntervenÃÃo, prevaleceu o movimento franzir de testa no Grupo Experimental, movimento de cabeÃa no Grupo Controle nos oito minutos iniciais. Jà nos dois minutos finais, a expressÃo dormindo manifestou-se equivalente nos grupos, com significÃncia favorÃvel à mÃsica para olhar vago (p<0,001). Ao comparar o Momento PrÃ-IntervenÃÃo com o Doloroso, o teste de Fisher indicou que a mÃdia de dor foi igual no Grupo Experimental (7,6Â1,8) e no Grupo Controle (8,0Â2,8). Os valores mÃdios do NFCS foram semelhantes nos dois grupos nos Momentos Basal, RecuperaÃÃo 1 e RecuperaÃÃo 2, com diferenÃa estatisticamente significante no Momento Tratamento (p=0,014) e no Momento Doloroso (p=0,029) para Grupo Controle (teste de Bonferoni), mas nÃo mostraram efeito do tempo com a intervenÃÃo (Wilkâs Lambda=0,207; F=1,314; p=0,316); tambÃm, nÃo houve tendÃncia de crescimento ou decrÃscimo do escore de dor (Wilkâs Lambda=0,184; F=1,517; p=0,223). Nas variÃveis neonatais numÃricas e terapÃuticas, os recÃm-nascidos do Grupo Experimental e do Controle versus valores totais do NFCS no Momento Doloroso nÃo se mostraram com p significante quando avaliados pelo teste t-Student. Conclui-se que a hipÃtese de nÃo inferioridade do efeito da mÃsica em relaÃÃo à soluÃÃo de glicose 25% nos Momentos Tratamento e Doloroso foi inconclusiva, considerando-se vÃlida nos Momentos Basal, RecuperaÃÃo 1 e RecuperaÃÃo 2, conforme os escores de dor do NFCS em recÃm-nascidos prÃ-termo.

This study was undertaken primarily to investigate the plasma protein system in infants with IRDS, as compared with healthy premature infants, as it had previously been reported that the plasma protein concentration in affected infants was abnormally low. It was attempted further to establish biochemical and/or immunological criteria for diagnosis of the disease and to discover reasons for the low IgG concentrations and raised α-fetoprotein concentrations found in the sera of these infants. Maternal serum proteins were also studied during pregnancy and at and after delivery of the infant. Interrelationships between α-fetoprotein, Human Growth Hormone and other proteins, in immunochemical systems were investigated. In summary, the main conclusions reached were as follows: (i) The total serum-protein concentration in affected infants is much reduced, as compared with healthy premature infants of the same gestational age. (ii) In IRDS infants, the relative and absolute concentration, of IgG is extremely low, whereas concentrations of other immune globulins, as far as could be determined, are within normal limits. (iii) Mothers of affected infants have significantly lower concentrations both of serum IgG and of IgM, than mothers of healthy premature infants. These changes in the serum-proteins are present throughout pregnancy. By six weeks post-partum, the IgG level has returned to normal, but the IgM level remains low. Concentrations of IgA and total serum-protein are normal at all times. (iv) Examination of oedema fluid, urine, faeces and amniotic fluid for γ-globulin content, has excluded the possibility that IgG is being lost from the circulation by these routes. (v) IRDS infants have, in their serum, agglutinins of the IgM type directed against the intact maternal IgG molecule. Similar agglutinins are present in a minority of healthy premature infants. Both IRDS and healthy infants have agglutinins against IgG fragments, in approximately 50% of cases. Agglutinin titres against these are similar in the two groups, but the incidence of agglutinins against Bence Jones protein type Lis raised in IRDS. (vi) Affected infants have an elevated serum concentration of α-fetoprotein, which disappears from the serum during the: first week of post-natal life. (vii) The majority of pregnant women examined have been observed to have serum agglutinins directed against α-fetoprotein. These cross-react with albumin prepared from sera of healthy adult males α-fetoprotein has been found in the serum of many pregnant women, especially during the second trimester. (viii) Immunological interrelationships between α-fetoprotein human serum albumin, Human Growth Hormone and human IgG have been demonstrated. (ix) Infants suffering from Rh-isoimmunization exhibit a serum- protein pattern similar to that seen in IRDS. Biochemical and immunological criteria for the diagnosis of IRDS have thus been established. The data to be presented indicate the presence of an immunological factor in the aetiology of the disease.