Despite the extensive research being done in inter-organizational systems (IOS) adoption in the industry-to-industry field, there seems to be a lack of similar research being done in the IOS adoption for the university-to-industry context. This study takes up this lack of research and focuses on what factors that affect the adoption of IOS in the university-to-industry context instead of the industry-to-industry one. The purpose of this paper is to find how different factors influence IOS adoption decision in the university-to-industry context from the university’s perspective. The study was conducted with a qualitative approach. Five interviews were conducted with coordinators and researchers from different research units at Linnaeus University. The study found seven inter-relationships among the influential factors and how they affect the IOS adoption decision. A model that describes the relations is presented by the end of the study. The study is conducted in the qualitative nature and the sample size is rather limited. Therefore, the findings of the study cannot be generalized.