This study addresses the antecedents of individuals' disposition to use telemedicine applications, as well as the antecedents of their usage to provide insight into creating sustained usage over time. The theoretical framework of this research is Bhattacherjee's expectation-confirmation IS continuance model. By combining a series of key factors which may influence the initial and continued usage of telemedicine applications with key constructs of Bhattacherjee's IS continuance model, this study aims to provide a deeper understanding of barriers to telemedicine app usage and how to facilitate continued use of these apps. Online survey data was collected from college students who are telemedicine application users. A total of 313 responses were gathered, and data analysis was conducted using SmartPLS 3. This dissertation contributes by looking at the IS adoption and IS continuance research simultaneously to connect these two research streams as well as suggesting the usage context of some established IS theory being different with regard to healthcare applications.