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Over the past decade, the illicit drug market has experienced an explosion of designer drugs being produced by clandestine laboratories that include modifications of illicit drugs that dominated drug markets for long periods of time (e.g. cathinones and MDMA). These designer drugs, which are commonly known as “legal highs”, are popular due to that fact that they are legally obtainable and not currently controlled. Examples of these include the phenylalkylamine analogues 5-iodo-2-aminoindane (5-IAI) and 5, 6-methylenedixoy-2-amonindane (MDAI), which have similar biological effects to MDMA. In spite of the unknown risk factors associated with these substances, it is believed that “legal highs” continue to have high levels of interest among recreational users. As such, the potential for abuse is high, and 5-IAI and MDAI are under consideration in numerous jurisdictions for regulation. Many of these novel compounds have never been analyzed previously within a forensic setting. The chemical and physical properties of 5-IAI and MDAI are not fully understood. As a result, the analytical analysis of “legal highs” can be challenging. Color test kits provide a quick screening method for law enforcement officials looking to presumptively identify a substance in the field. The difficulty with this form of analysis is that most of the active ingredients present in “legal highs” are not detected by standard presumptive tests, or the results when the tests are used are ambiguous. Gas chromatography-mass spectrometry (GC-MS) is one of the most utilized analytical instruments in forensic laboratories for the identification of drugs of abuse. However, due to the rapid development and commercialization of “legal highs,” the limited availability of certified reference standards and mass spectral data make the confirmatory analysis of “legal highs” challenging. The primary aims of this research were two-fold. The first was to evaluate selected commercially available Narcotics Analysis Reagent Kits (NARK® II) and color reagent formulations recommended by the National Institute of Justice (Color Tests Reagents/ Kits for Preliminary Identification of Drugs of Abuse) to determine if the phenylalkylamine analogues 5-IAI and MDAI generate a color development. If a color was generated using a particular reagent, further testing was conducted to establish if the observed color would be detectable in the presence of various adulterants. The second aim of this research was to develop a rapid GC-MS method for the detection of 5-IAI and MDAI in contrived multi-component mixtures of selected adulterants. Standard color tests provided consistent results for 5-IAI and MDAI pure samples as well as mixtures with adulterants. 5-IAI produced a light brown color with both the Marquis and the methylenedioxypyrovalerone (MDPV) color reagent tests. The Mandelin reagent from the NARK® II test kit produced a greenish brown color and a light green color with the In-House preparations of the same reagent when tested with MDAI. Confirmatory analysis was performed using GC-MS with a temperature gradient. The analysis was performed on a non- polar (5% phenyl) methylpolysiloxane column with a total run time of 10 minutes. 5-IAI and MDAI were chromatographically separated and distinguishable from various adulterants based on retention time and mass to charge ratio.

Research relating to illicit use of prescription stimulants (IUPS) has, for the most part, focused on describing behaviors of IUPS. However, there have been few attempts to measure IUPS in a consistent manner or determine how to best predict IUPS in an effective and concise manner. Data from Mississippi State University undergraduates (N = 703) were analyzed to create two shortorm measures to predict lifetime IUPS. The data-driven shortorm consisted of 15 items and 5 factors, and accurately classified 74.8% of participants as users versus non-users. The hand-picked shortorm consisted of 8 items and 5 factors, and accurately classified 84.6% of participants as users versus non-users. Results of this study can begin to provide information and possible tactics for briefly and quickly measuring risk for IUPS, particularly in applied settings, like university health centers or academic admissions. Future directions for research include testing these created shortorm measures with longitudinal data collection, validating the measures on different populations, and determining if these measures can accurately predict specific behaviors related to IUPS (e.g., diversion, IUPS within certain time frames).

The purpose of this mixed methods study was to identify demographic and psychosocial correlates of illicit drug use among pregnant women and to explore the life experiences and circumstances that contribute to women’s use of illicit drugs during pregnancy. A sequential explanatory mixed-methods design consisting of quantitative and qualitative components was used. The results of the quantitative component found that women who are depressed, of First Nations ethnicity, drink alcohol during pregnancy, smoke during pregnancy, and have low self-esteem are more likely to use illicit drugs during pregnancy. The qualitative component of the study identified four themes that impacted women’s use of illicit drugs during pregnancy. These included: (1) living a chaotic life as a child, (2) complicated life circumstances, (3) social support system, and (4) the road to recovery. The information gathered during this study will inform practice and policy and may guide future research in this area.

The purpose of this mixed methods study was to identify demographic and psychosocial correlates of illicit drug use among pregnant women and to explore the life experiences and circumstances that contribute to women’s use of illicit drugs during pregnancy. A sequential explanatory mixed-methods design consisting of quantitative and qualitative components was used. The results of the quantitative component found that women who are depressed, of First Nations ethnicity, drink alcohol during pregnancy, smoke during pregnancy, and have low self-esteem are more likely to use illicit drugs during pregnancy. The qualitative component of the study identified four themes that impacted women’s use of illicit drugs during pregnancy. These included: (1) living a chaotic life as a child, (2) complicated life circumstances, (3) social support system, and (4) the road to recovery. The information gathered during this study will inform practice and policy and may guide future research in this area.

Fetal alcohol spectrum disorder (FASD) is the leading non-genetic cause of brain damage. In an effort to reduce alcohol-exposed pregnancies, steps are needed to identify at risk women as early as possible so that appropriate intervention can occur. The objective of this dissertation was to examine screening methods validated in identifying pregnant women at risk for consuming alcohol and illicit drugs during pregnancy. A systematic review identified three main approaches including maternal self-report, use of standardized questionnaires and detection via biological markers. Since most screening tools were developed in alcoholic women, it was important to examine performance in problem drinkers. Alcohol screening tools (ASQ), currently the best method of predicting prenatal problem drinking, were not effective in a cohort representative of problem drinkers. ASQ performance improved minimally, using higher thresholds, but not enough to be used alone. Provider’s knowledge of complexities inherent in women under their care is an important component in screening. As illicit drug use is an important predictor of problem drinking, identifying maternal risk factors associated with substance use was necessary. Increased rates of STD’s, untreated psychiatric disorders, binge drinking and heavy smoking were all identified as predictors of prenatal methamphetamine (MA) use. These factors, combined with high rates of unplanned pregnancies have serious adverse implications for the fetus. The most widely used method to screen for illicit substance use is based on a practice-based approach that relies heavily on maternal self-report. Most providers do not ask about alcohol and substance use in the absence of a high index of suspicion due to the assumption that patient will deny use. But evidence suggests that maternal account can be accurate in a supportive environment. The last study examines the agreement between self-reported data, in comparison to illicit drug use based on positive hair test results. A reasonable agreement between the two approaches of identification demonstrates that maternal self-report can be reliable in women who are motivated enough to seek prenatal care. No single approach is sufficient to effectively identify at risk women. However, combining two or more methods will improve screening and help reduce the number of alcohol-exposed pregnancies.

Fetal alcohol spectrum disorder (FASD) is the leading non-genetic cause of brain damage. In an effort to reduce alcohol-exposed pregnancies, steps are needed to identify at risk women as early as possible so that appropriate intervention can occur. The objective of this dissertation was to examine screening methods validated in identifying pregnant women at risk for consuming alcohol and illicit drugs during pregnancy. A systematic review identified three main approaches including maternal self-report, use of standardized questionnaires and detection via biological markers. Since most screening tools were developed in alcoholic women, it was important to examine performance in problem drinkers. Alcohol screening tools (ASQ), currently the best method of predicting prenatal problem drinking, were not effective in a cohort representative of problem drinkers. ASQ performance improved minimally, using higher thresholds, but not enough to be used alone. Provider’s knowledge of complexities inherent in women under their care is an important component in screening. As illicit drug use is an important predictor of problem drinking, identifying maternal risk factors associated with substance use was necessary. Increased rates of STD’s, untreated psychiatric disorders, binge drinking and heavy smoking were all identified as predictors of prenatal methamphetamine (MA) use. These factors, combined with high rates of unplanned pregnancies have serious adverse implications for the fetus. The most widely used method to screen for illicit substance use is based on a practice-based approach that relies heavily on maternal self-report. Most providers do not ask about alcohol and substance use in the absence of a high index of suspicion due to the assumption that patient will deny use. But evidence suggests that maternal account can be accurate in a supportive environment. The last study examines the agreement between self-reported data, in comparison to illicit drug use based on positive hair test results. A reasonable agreement between the two approaches of identification demonstrates that maternal self-report can be reliable in women who are motivated enough to seek prenatal care. No single approach is sufficient to effectively identify at risk women. However, combining two or more methods will improve screening and help reduce the number of alcohol-exposed pregnancies.

Magister Legum - LLM / This paper attempts a comprehensive analysis of the offence of illicit enrichment in Zambia. It focuses on how the offence fits into the broader legislative framework in Zambia. More importantly, the paper addresses aspects of the offence related to the presumption ofinnocence, the protection against self-incrimination and the presumption of legality in the light of the Zambian Constitution to determine whether the concerns raised are legitimate. Also, considering the potential effectiveness of criminalising illicit enrichment by public officials, this study investigates whether the law in Zambia can be implemented to balance the constitutional rights of the accused and the right of society to recover illicitly obtained wealth. Finally, the research seeks to determine the possible challenges of implementing and prosecuting the offence, and its efficacy in the fight against corruption in Zambia.

Magister Legum - LLM / Corrupt practices such as bribery and other abuses of public functions for private gain have been criminalised in almost all legal systems. Criminalisation of acts of corruption constitutes one of the major dimensions of the international anti-corruption instruments. The clandestine nature of corruption crimes creates difficulties in gathering evidence for prosecution and effective implementation of the law. To overcome such problems, some indicators of corruption such as possession of property that far exceeds legitimate sources of income need to be criminalised. It is also imperative to deal with the challenges associated with such criminalisation. This paper tries to analyse the challenges related to due process of law in the investigation and prosecution of illicit enrichment. Further, complexities associated with the process of recovering illicitly acquired assets, such as resources and expertise, as well as effective co-operation among various jurisdictions, need to be explored. Special consideration will be given to the criminalisation of illicit enrichment and its prosecution in the Ethiopian anti-corruption legal framework.