The senseFly eBeePlus fixed-wing drone is a market available UAV compatible with a range of sensors that includes the Parrot Sequoia+ multispectral camera. Commercial applications of the drone predominantly focus on agriculture, environmental management, and engineering applications. The Sequoia 4-band multispectral sensor with bands optimised for plant health analysis, has a spectral range that coincides with the absorption features of iron. Previous studies with the use of hyperspectral sensors on multicopter UAVs have proven successful in the detection and delineation of hydroxides and sulphates associated with weathering of sulphides at the surface. This study aims to evaluate the ability of the eBeePlus drone equipped with a Parrot Sequoia+ sensor to effectively detect and delineate surficial sulphide mineral expressions by testing its capability on a known nickel-copper mineralisation occurrence at Illukunnguaq, on the north-western coast of Disko Island, West Greenland. Formally hosting a 28-tonne nickeliferous pyrrhotite massive sulphide boulder, many companies have sought this region for a possible extension of the mineralisation or another local mineral occurrence. Iron-feature band ratios and Spectral Angle Mapping (SAM) are two methods tested to first characterise the known occurrence, then search the wider region for other features with a similar signature as the Illukunnguaq dyke. To assist the evaluation and fine tune the Sequoia sensor, it will be compared against the trialled and trusted Rikola hyperspectral sensor, proven to map iron features. In addition, eigen maxima as one of many geomorphological indices that utilise the co-product Digital Surface Model (DSM) of the spectral survey, is employed to assess whether the Illukunnguaq dyke and other features are structurally mappable.  Results show that the Sequoia multispectral sensor, albeit less spectrally resolved than the Rikola hyperspectral sensor was able to detect surficial sulphide mineral expressions both by applying iron-feature band ratios and SAM. The latter was performed using laboratory measured and open-access library spectra. To fine-tune the tools compatible with the Sequoia sensor, in-depth investigations into iron-feature band ratio index values and best-fit library spectra for SAM was conducted. Confidence was increased by the blind detection of another known exposure and permitted a regional search to find additional features with spectral similarities to the Illukunnguaq dyke for future ground truthing. This study demonstrates that the eBeePlus drone can be used for mineral exploration when iron-sulphides are a part of the mineral system and outcropping at the surface. Leading field programs with detailed multispectral mapping can improve the efficiency of geologists by generating or verifying targets prior to ‘boots-on-the-ground’ geological sampling or mapping.