Guided by attachment theory and principles of positive psychology, a conceptual model was developed depicting the direct and indirect effects of attachment insecurity, state hope, belongingness, and meaning in life on wellness indicators (i.e., life satisfaction, physical health, and depression) of first generation Latino immigrants in the U.S. Specifically, the present study proposed that the effects of attachment insecurity on Latino immigrants' wellness would be mediated by two tiers of factors. The first tier consisted of state hope (i.e., general state hope, spiritual state hope, mastery state hope) and sense of belonging (i.e., general belongingness; connectedness with mainstream/ethnic community), which represented individual-level and relational factors, respectively, salient in Latino culture. Greater attachment insecurity was hypothesized to contribute to a compromised MIL and poorer wellness by decreasing state hope and sense of belongingness. A total of 352 first-generation Latino immigrants from Texas participated in this study. The exploratory factor analysis on the Experiences in Close Relationships Scale revealed a two-factor factor structure that is different from the two factors of adult attachment typically found with American samples (i.e., anxiety and avoidance). The emerged two factors represent anxious-distancing attachment and comfort-seeking attachment. Results from structural equation modeling analysis showed adequate model fit with the data. The final model indicated that the effects of comfort-seeking attachment on wellness were fully mediated by two layers of mediators (belongingness and state hope as the first layer and meaning in life as the second layer). In addition, the effect of anxious-distancing attachment on wellness was fully mediated by belongingness and meaning in life but not through state hope. Bootstrap methods were used to assess the significance magnitude of these indirect effects. Comfort-seeking attachment explained 13% of the variance in state hope and both attachment variables explained 36% of the variance in sense of belongingness. Anxious-distancing attachment, comfort-seeking attachment, state hope, and sense of belongingness explained 78% of the variance in meaning in life, and the overall model explained 75% of the variance in wellness. Limitations, future directions, and implications for counseling and theory are discussed from attachment theory, positive psychology, and immigration perspectives.