Thesis (Ph. D.)--State University of New York at Binghamton, Chemistry Department, 2001. / Includes bibliographical references (leaves 209-237).

Microarray technology like that of recombinant DNA and the polymerase chain reaction is a foundational component of modern biotechnology. There are many aspects in the manufacture of a DNA chip and each serves as a contributing variable to the overall performance of the device. Commercial production of microarrays commenced before a basic understanding of the physical and chemical processes that govern the many variables was attained and the role of each on the performance of microarrays was understood. The consequence of this has been non-optimal performance of this technology and variable results from microarray analyses. Recent studies have shown that part of the variability in the use of commercially available microarrays relates to insufficient control of the surface chemistry within a microarray spot and between spots. Although the ideal characteristics of a microarray surface have been identified, existing surfaces and the ongoing proliferation of alternative ones do not address these sufficiently in order to reduce the sources of error arising from the surface of a microarray. Hence, the application of physico-chemical techniques in the development of microarrays surfaces can assist in improving the performance of these devices. / Thesis (PhDApSc(MineralsandMaterials))--University of South Australia, 2006.

Thesis (Ph. D.)--University of Washington, 2006. / Vita. Includes bibliographical references (leaves 213-235).