Global ETD Search

1	The Role of Human Immunodeficiency Virus Type 1 Nucleocapsid Protein in Viral Replication Li, Xuguang January 1996 (has links) Note: Immunodeficiency
2	Analysis of seven leukocyte adhesion deficiency (LAD) point mutations in the integrin #beta#2 subunit Scarth, Sarah L. January 1999 (has links) No description available. 610 Immunodeficiency
3	Immunoregulatory properties of polyclonal immunoglobulin for therapeutic use Alder, Louise B. A. January 1996 (has links) No description available. 610 Immunodeficiency
4	Transcriptional activation of human immunodeficiency virus type 1 by NF-κb Matthews, James Robert January 1993 (has links) This study has analysed some of the mechanisms involved in the transcriptional activation of the human immunodeficiency virus type 1 (HIV-1) by transcriptional modulator proteins of the NF-ĸB/rel family. Initial attempts to purify a single NF-ĸB (p50-p65) heterodimer species from HeLa cells suggested that a family of proteins might contribute to ĸB motif DNA binding activity. HeLa cell ĸB motif DNA binding proteins were shown to be modified by glycosylation. Using circularly permuted DNA probes carrying a KB motif, it was shown that ĸB binding proteins induced significant DNA bending upon binding, while studies of the effects of the poly amine spermidine on purified HeLa cell ĸB motif DNA binding proteins showed it greatly stimulated their DNA binding activity. The DNA binding activity of native ĸB motif DNA binding proteins was also greatly stimulated by the reducing agent dithiothreitol. Using a cDNA encoding the p105 precursor to the NF-ĸB p50 subunit, the wild type DNA binding and dimerisation region (aa35-381) of p50, and three cysteine to serine mutants at cysteine residues (aa62, 119, and 273) conserved throughout the NF-ĸB/rel/dorsal family, were expressed in bacteria. The dissociation constant of the aa62 p50 mutant for the ĸB motif was 10-fold higher than that of the wild type p50. Also, dissociation rate constants for the aa62 mutant-KB motif complex in both the presence and absence of spermidine were anomalously high. The above changes suggested a different DNA binding specificity for the aa62 mutant - this was confirmed by oligonucleotide competition studies. Oligonucleotide protection experiments suggested the presence of a cysteine residue in the p50 DNA binding site-substrate protection experiments showed that this was cysteine 62, and that this residue is involved in redox regulation of p50 DNA binding activity. QR188.35M2 ; Immunodeficiency
5	Study of B lymphocyte subset phenotypes and clinical features of common variable immunodeficiency patients in Hong Kong Lo, Ching-ha., 盧靜霞. January 2009 (has links) published_or_final_version / Pathology / Master / Master of Medical Sciences Lymphocytes. Phenotype. Immunodeficiency.
6	An investigation of susceptibility of alveolar macrophages to HIV 1 infection Alimohammadi, Azin January 2002 (has links) No description available. 579 Human immunodeficiency virus
7	In vitro studies of SIV nef function Karim, Shamim Akhtar January 2003 (has links) No description available. 616 Immunodeficiency viruses
8	The analysis of the in vivo effects of the HIV-1 Nef and Tat regulatory genes using a transgenic mouse system Pennington, Daniel John January 1996 (has links) No description available. 572.8 HIV; Immunodeficiency; AIDS
9	Induction and characterisation of antibody responses in macaques immunised with recombinant SIV antigens Bergmeier, Lesley Ann January 2001 (has links) No description available. 610 Human immunodeficiency virus
10	An investigation of mutant cell lines deficient in the expression or function of the MHC class II genes Quan, Virginia Anne January 2001 (has links) No description available. 572.8 Autosomal; Immunodeficiency

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