This exploratory enquiry into the effectiveness of an in-patient psychotherapy program measured the changes in mood and anxiety symptoms, difficulty with emotion regulation, and dispositional mindfulness in a clinical population with diverse psychiatric morbidity. Participants were 53 adults (74.5% female, mean age = 35 years) who participated in a 4-week in-patient psychotherapy program offering a variety of interventions, including mindfulness skills training, and Dialectical Behaviour Therapy-psychosocial skills training. Program input data, demographic variables, psychiatric morbidity, and medication on discharge were tracked. There was an average improvement of 29.86 ± 20.56 on the Mood and Anxiety Symptoms Questionnaire-D30 and 12.43 ± 17.75 on the Difficulty with Emotion Regulation Scale-Short Form, indicating an improvement in mood and anxiety symptoms and emotion regulation post-intervention. There was an average improvement of 17.6 ± 23.66 on the Five Facets of Mindfulness Questionnaire, indicating an increase in dispositional mindfulness post-intervention.