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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
41

Molecular and cellular mechanisms contributing to the pathogenesis of autoimmune diabetes /

Duarte, Nadia, January 2005 (has links)
Diss. (sammanfattning) Umeå : Univ., 2005. / Härtill 4 uppsatser.
42

The genetic basis of T and B cell contribution to autoimmune diabetes in NOD mice /

Motta, Vinícius, January 2006 (has links)
Diss. (sammanfattning) Umeå : Umeå universitet, 2006. / Härtill 4 uppsatser.
43

The role of beta2-glycoprotein I-reactive T cells in antiphospholipid syndrome

Tolomeo, Tanya. January 1900 (has links)
Thesis (M.Sc.). / Written for the Dept. of Microbiology and Immunology. Title from title page of PDF (viewed 2008/07/30). Includes bibliographical references.
44

Genomic determinants of alcohol effects /

Hu, Wei, January 2008 (has links)
Thesis (Ph.D. in Pharmacology) -- University of Colorado Denver, 2008. / Typescript. Includes bibliographical references (leaves 121-149). Free to UCD Anschutz Medical Campus. Online version available via ProQuest Digital Dissertations;
45

TGF-[beta]-induced regulatory T cells in type I diabetes : function and antigen dependence /

Tonkin, Daniel R. January 2007 (has links)
Thesis (Ph.D. in Immunology) -- University of Colorado Denver, 2007. / Typescript. Includes bibliographical references (leaves 182-202). Free to UCD affiliates. Online version available via ProQuest Digital Dissertations;
46

Regulation of neural precursor cell apoptosis and proliferation by glycogen synthase kinase-3

Eom, Tae-Yeon. January 2009 (has links) (PDF)
Thesis (Ph.D.)--University of Alabama at Birmingham, 2009. / Title from first page of PDF file (viewed on June 8, 2009). Includes bibliographical references.
47

A novel microencapsulated probiotic yogurt formulation for oral delivery in the suppression of intestinal tumorigenesis in ApcMin mice

Urbanska, Aleksandra Malgorzata. January 1900 (has links)
Thesis (Ph.D.). / Written for the Dept. of Biomedical Engineering. Title from title page of PDF (viewed 2009/06/11). Includes bibliographical references.
48

Estabilidade e adaptabilidade para caracteres de produção em linhagens de milho /

Koshima, Fernando Akira Takada. January 2009 (has links)
Orientador: José Roberto Moro / Banca: Ricardo Machado da Silva / Banca: Sandra Helena Unêda Trevisoli / Resumo: O presente trabalho foi realizado em duas Fazendas Experimentais da Monsanto do Brasil Ltda, localizadas nos municípios de Barretos - SP e Rolândia - PR, na safra verão 2007/08. O objetivo deste trabalho foi avaliar os parâmetros de estabilidade e adaptabilidade de oito linhagens elites de milho (seis utilizadas como fêmea e duas como macho em cruzamentos de híbridos simples comerciais e experimentais) em oito ambientes pelo modelo de EBERHART & RUSSELL. Os ambientes foram caracterizados por duas localidades, duas épocas de semeadura (setembro e outubro) e dois sistemas de manejo de solo (convencional e plantio direto). Utilizou-se o delineamento em blocos casualizados com quatro repetições. Avaliaramse os caracteres de produção de grãos (kg ha-1), rendimento de sacos de sessenta mil sementes por hectare, altura de plantas, altura de espiga e comprimento de espiga. Constataram-se efeitos significativos para as linhagens, ambientes e interação linhagens x ambiente para todas as características avaliadas. Observou-se que todas as linhagens tiveram comportamento imprevisível para produção de grãos. De uma forma geral, observou-se uma maior produção de grãos no ambiente de Rolândia, semeado em setembro no sistema de plantio direto. O ambiente que propiciou a maior produção de grãos, necessariamente não é o ambiente com maior rendimento de sacos de 60 mil sementes por hectare. Os ambientes de Barretos se mostraram propícios para aumentar os parâmetros de altura de planta e altura de espiga. Três das oito linhagens mostraram uma adaptabilidade a ambientes desfavoráveis, enquanto que as demais linhagens ... (Resumo completo, clicar acesso eletrônico abaixo) / Abstract: This work was conducted in two Monsanto's farms, located in the cities of Barretos - SP and Rolândia - PR during the 2007/08 summer season. The objective of this work was to evaluate the parameters of stability and adaptability of eight Elite inbred lines of maize (six used as female and two used as male in single crosses of commercial and experimental hybrids) in eight environments by EBERHART & RUSSELL's method. The environments were characterized by two locations, two planting dates (September and October) and two systems of soil tillage (no till and tillage). The experimental design used was a complete randomized block with four replications. It was observed the characters of grain yield (kg ha-1), weight of thousands kernels, yield of sixty thousand kernels bag ha-1, plant height, ear height and ear length. It was evidenced significant effects for inbred lines, environments and inbred lines x environment interaction for all traits evaluated. It was observed that all inbred lines showed unstable behaviour. In general, there was a higher grain yield in environment of Rolândia, planted in September in no till system. The environment with the highest grain yield, not necessarily is the environment with highest yield of 60 thousand kernels bags ha-1. Environments of Barretos showed conditions to increasing the parameters of plant height and ear height. Three of eight inbred lines showed an adaptability to unfavorable environments, while other inbred lines showed an adaptability to favorable environments. Only two inbred lines showed the coefficient of determination above 80%. In general, the inbred line 8-F had the fourth highest grain yield (2675.3 kg ha-1) and ... (Complete abstract click electronic access below) / Mestre
49

Potencial heterótico de linhagens S3 e S4 de milho (Zea mays L.) para obtenção de híbridos

Buchweitz, Elizandra Döring [UNESP] 24 February 2010 (has links) (PDF)
Made available in DSpace on 2014-06-11T19:26:08Z (GMT). No. of bitstreams: 0 Previous issue date: 2010-02-24Bitstream added on 2014-06-13T20:14:42Z : No. of bitstreams: 1 buchweitz_ed_me_jabo.pdf: 457129 bytes, checksum: fa6a9d6b3e092340a34ec3de2d5161cc (MD5) / Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) / Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) / A baixa freqüência de genes recessivos deletérios e letais e a grande proporção de locos favoráveis já fixados nos híbridos comerciais, associado a uma seleção fenotípica eficiente entre e dentro de linhagens pode permitir a obtenção de híbridos promissores. Em média, são gastos de 8 a 10 anos para que um novo híbrido chegue ao mercado, o que implica diretamente no custo final das sementes. Para reduzir esse tempo é interessante viabilizar a utilização de linhagens parcialmente endogâmicas nos cruzamentos para agilizar o processo de obtenção de híbridos superiores e reduzir os custos da produção de sementes híbridas. Diante da necessidade de identificar híbridos de destaque e de encontrar alternativas que conduzam à redução dos custos e do tempo para a obtenção de sementes híbridas, o objetivo desse trabalho foi avaliar o potencial de linhagens parcialmente endogâmicas de milho com três (S3) e quatro (S4) gerações de autofecundação, obtidas de híbridos simples comerciais, com relação à heterose dos híbridos resultantes / The low frequency of deleterious recessive and lethal genes and the large proportion of favorable loci already set in commercial hybrids combined with an efficient phenotypic selection among and within strains may allow the achievement of promising lines. On average, spending 8 to 10 years for a new hybrid to reach the market, which directly implies the final cost of the seeds. To reduce this time it is interesting to enable the use of partly inbred lines at intersections to expedite the process of obtaining superior hybrids and reduce the costs of producing hybrid seeds. Faced with the need to identify hybrids highlighted and to find alternatives that lead to the reduction of costs and time required for the production of hybrid seeds, the purpose of this study was to evaluate the potential of partly inbred lines of maize with three (S3) and four (S4) generations of selfing, obtained from commercial single cross hybrids, with respect to the follow-on hybrid heterosis
50

Efeito da hipertensão e do atenolol sobre a atividade salivar e a microdureza dental: estudo experimental em filhotes de ratas espontaneamente hipertensas (SHR)

Elias, Gracieli Prado [UNESP] 15 December 2006 (has links) (PDF)
Made available in DSpace on 2014-06-11T19:33:01Z (GMT). No. of bitstreams: 0 Previous issue date: 2006-12-15Bitstream added on 2014-06-13T19:03:54Z : No. of bitstreams: 1 elias_gp_dr_araca.pdf: 1560641 bytes, checksum: 3dad8c2298005cfeb8d0a078880f5e66 (MD5) / Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) / O objetivo deste trabalho foi avaliar a atividade das glândulas salivares, a mineralização dental e a participação da metaloproteinase de matriz (MMP-9) nesta mineralização em filhotes de ratas espontaneamente hipertensas (SHR) tratadas ou não com atenolol. Ratas SHR e normotensas Wistar foram tratadas com atenolol (100mg/Kg/dia, via oral) durante os períodos de prenhez e lactação. Os grupos controle receberam o mesmo volume de água sem atenolol. O fluxo salivar, induzido por nitrato de pilocarpina, a concentração de proteínas (método de Lowry), a atividade da amilase (método cinético a 405 nm), o peso das glândulas salivares (parótidas, submandibulares e sublinguais), a microdureza do esmalte e da dentina de incisivos e molares e a expressão da MMP-9 (imonuperoxidase) no tecido dental foram comparados entre filhotes de ratas SHR e Wistar tratadas ou não com atenolol. Os resultados obtidos foram submetidos ao teste estatístico mais adequado, paramétrico (ANOVA ou test t de Student’s) ou não paramétrico (Kruskal-Wallis), sendo consideradas significativas as diferenças quando p<0,05. Filhotes SHR apresentaram menor fluxo salivar e concentração de proteínas do que filhotes Wistar, mas a atividade da amilase não foi diferente entre os grupos. O peso das glândulas salivares foi semelhante entre filhotes SHR e Wistar... / The objective of the present study was analyzed the salivary activity, the dental mineralization and the role of matrix metalloproteinase-9 (MMP-9) on this mineralization, in pups (30 days) of spontaneously hypertensive rats (SHR) treated, or not treated, with atenolol. Female SHR and normotensive Wistar rats were treated during pregnancy and lactation periods with Atenolol 100mg/Kg/day by oral administration. For the control group, the animals received the same water volume without the drug. The salivary flow rate (stimulated by pilocarpine injection), the protein concentration (Lowry method), salivary amylase activity (kinetic method at 405 nm), the weight of salivary glands (parotid, submandibular and sublingual), the enamel and dentin microhardness of incisors and molars teeth and the matrix metalloproteinase-9 (MMP-9, gelatinase B) localization (imunoperoxidase) in dental tissue were compared between SHR and Wistar pups of female rats treated or not with atenolol. The results were analyzed by parametric (ANOVA or Student s tests) or non-parametric (Kruskal-Wallis) tests (p<0,05). The salivary flow rate and salivary protein concentration were reduced in SHR pups. There was no alteration in amylase activity between groups. The salivary glands weight was not different between SHR and Wistar pups either. Decreased enamel and dentin microhardness were observed in incisors and molar teeth of SHR pups. No alterations in MMP-9 positive staining were observed in predentin and odontoblasts of both groups, however the density of stained ameloblasts cells and external enamel surface were higher in incisors teeth of SHR pups. Atenolol-treated SHR and Wistar rats pups showed decrease in submandibular gland weight, in saliva s flow rate and protein concentration, but no alteration in amylase activity. Atenolol increased enamel and dentin microhardness of incisors teeth of SHR and...(Complete abstract, click electronic address below)

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