A co-creation framework was developed for non-Indigenous scientists and engineers aiming to conduct research with Indigenous communities. Developed from pre-existing CBPR and co-creation theories, this guide incorporated the personal experiences of two master's students working on this project. As Indigenous communities and individuals are not monoliths, the first draft of this framework was devised to be expanded for use with various other groups allowing researchers to apply relevant concepts specific to their projects. The co-creation framework was developed and executed by conducting an initial water quality analysis of drinking water from SN. Initiated by Duignan’s 2019 SN health survey feedback, preliminary water parameters were analyzed for select households across the community. Community services and members were instrumental in co-creating this style of data collection and knowledge translation with GWF researchers. Collections methods were primarily adapted due to the COVID-19 pandemic, in which researchers were led initially by community liaisons and taken to households to collect drinking water samples. Instead, homeowners were supported in collecting their own drinking water samples and providing them to community educators from SNHS. Concurrently, further development and application of the framework were established through an interactive video podcast, Ohneganos Let’s Talk Water, employed to conduct, disseminate, and translate relevant community research. The community-centred methodology met the target audience where they were, on social media, rather than expecting them to decipher conventional WS science dissemination methods such as academic conferences or peer-reviewed papers. International and transdisciplinary collaboration was explored between Indigenous and non-Indigenous youth, students, experts, artists and community members. This multifaceted, award-winning show was the first to combine these various elements. A mixed methods approach via digital story was produced to illustrate the impact of LTW. While an extensive variety of guests and topics were discussed in the four seasons of the podcast, the digital story highlights those most closely aligned with the work of this thesis, decolonizing western science research and dissemination. / Thesis / Master of Environmental Studies (MES) / Guided by ten significant themes, knowledge sources including community feedback via social media, extensive literature review, conversations with elders and relevant graduate courses were applied to develop a co-creation framework to inform best practices for western scientists and engineers collaborating with Indigenous partners. Two case studies, community-led water testing “Preliminary Water Quality Assessment” and a community-led video podcast “Ohneganos – Let’s Talk Water,” were carried out to implement and supplement the iterative development of the framework to harmonize Indigenous Knowledge and Western Science.