Over 110,000 known methamphetamine (meth) clandestine labs were reported in the U.S. from 1999 to 2008. The production of meth is regarded as a national epidemic, and can lead to substantial contamination of indoor materials. Due to its chemical and physical properties, meth residual can persist on indoor surfaces and in indoor air for prolonged periods. Unfortunately, most remediation techniques lack strong scientific support and cleanup standards are inconsistent across different states. A better understanding of the mechanistic interactions between meth and indoor environment can help improve remediation strategies and the development of regulations. In this study, equilibrium partitioning coefficients (Ke) between a meth surrogate and wall materials were estimated based on laboratory experiments. The resulting Ke values were then used in a screening model to predict meth decay rates from wall materials and indoor air. The effects of ventilation and indoor air mixing on meth off gassing were explored. / text