Errata sheet has been pasted onto the front end-paper. / Bibliography: leaves 208-217. / x, 217 leaves : ill. (some col.) ; 30 cm. / Title page, contents and abstract only. The complete thesis in print form is available from the University Library. / Outlines a systematic synthesis and testing of continual sterilization design. Principal aim is to evaluate and develop mathematical models for sterilization, undertake experimental studies for determining thermal inactivation effects on continuous processing of a liquid containing contaminant bacteria and compare the data obtained with those predicted by a selected model. / Thesis (Ph.D.)--University of Adelaide, Dept. of Chemical Engineering, 2001?

Errata sheet has been pasted onto the front end-paper. Bibliography: leaves 208-217. Outlines a systematic synthesis and testing of continual sterilization design. Principal aim is to evaluate and develop mathematical models for sterilization, undertake experimental studies for determining thermal inactivation effects on continuous processing of a liquid containing contaminant bacteria and compare the data obtained with those predicted by a selected model.

The overall aim of this research was to explore why some hospitals are more successful than others at reducing the acquisition rates of multidrug-resistant organisms. Using a socio-ecological perspective on health systems adapted from works in ecological restoration, ecosystems management, and healthcare, a participatory comparative case study design was employed. The study was collaboratively conducted on a surgical unit at a Netherlands hospital with very low rates of multidrug-resistant organisms and a surgical unit in a Canadian hospital with higher rates of these pathogens. The cases were selected on the basis that they were both academic health sciences centres of similar size in publicly funded systems; yet, they reported differing rates of MDRO infections. Research methods included a total of six unit observations, nine practitioner-led photo walkabouts of the units (n=13), six photo elicitation focus groups with practitioners (n=26), and the review of relevant policies and procedures and related infection prevention and control data. Common findings across both cases include the perceived importance of engaged leadership, the presence of environmental design issues, a lack of antibiotic prescribing restrictions, and the frequent use of workarounds that may be problematic for infection prevention and control. Disparate findings between cases include differences in ratios of hospital beds per capita, bed occupancy rates, staffing practices, equipment cleaning processes, bed cleaning systems (centralized versus manual) and the presence, in one hospital, of an active grass roots Hygiene in Practice group engaging practitioners in several ongoing activities to promote infection prevention and control. There is a lack of comparable findings between the two cases on hand hygiene audit protocols, surveillance strategies, reporting of acquisition rates, and the nature and extent of high risk populations for community-acquired methicillin-resistant Staphylococcus aureus in the two hospitals catchment areas. The findings and methodological challenges identified in this study suggest that case selection in future comparative infection prevention and control case studies should be based on an expanded list of criteria. These criteria should include comparable audits, surveillance, and reporting practices and comparable demographic and other relevant data, such as data on the agricultural practices within and demographic attributes of vulnerable populations within the hospital catchment areas.

No description available.

Infections are a major source of morbidity and cause of mortality during the post-operative phase for patients. Wound infections are the second most commonly encountered type of nosocomial, hospital-acquired, infection in the United States (Nichols, 2007:8). Owing to the fact that wound infection may be induced, such as, by not applying infection control and sterile technique principles in the operating room complex, it is imperative to implement infection control principles and apply sterile technique principles. The researcher noticed that some of the sterile technique principles were not carried out in the operating room complex which lead to the necessity to assess the knowledge of registered nurses’ regarding the implementation of infection control and sterile technique principles. The main goal of the study was to explore and describe the knowledge of registered nurses’ in two private hospitals in the Nelson Mandela Metropole, related to infection control and sterile technique principles in the operating room complex. Following the analysis of the data, the researcher made recommendations for changes to be made to the existing infection control guidelines in the operating room complex. The research design was quantitative, explorative, descriptive and contextual in nature. The sample consisted of all the registered nurses known as scrub nurses, in the operating room complex. The unit managers were excluded from the study, because the researcher utilized their assistance with the handing out and collecting of the questionnaires because, not all scrub nurses were at work at the same time. Firstly a pilot study was conducted (in both private hospitals) to confirm the reliability of the data collection instrument. Data was collected by means of a questionnaire that was self-administered and consisted out of three sections: Section A – Biographical Data; Section B – Knowledge Base Related to Infection Control Principles and Section C – Knowledge Base Related to the Principles of Asepsis. The researcher consulted experts to ensure the reliability and validity of the questionnaires and to ensure that the iv questionnaires would measure what it is intended to measure and that it will remain consistent. The data obtained from the questionnaires was analyzed by means of statistical and inferential analysis and included descriptive statistics with the assistance of a statistician. Following the analysis of the data, recommendations for changes to be made to the existing infection control guidelines in the operating room complex was made. This was done with relevant literature and the guidelines were discussed with experts in the field. The researcher ensured that all the legal and ethical requirements, such as the participants’ right to privacy, were maintained throughout the study.

Aim: To assess and compile current knowledge and recommendations forinfection prevention and control (IPC) in dentistry during the COVID-19pandemic. Furthermore, to assess whether previous knowledge about IPC hascontributed to constructing evidence-based measures for IPC that can beuniversally applicable. Also, identifying knowledge gaps that need to beaddressed regarding IPC to be used effectively in future pandemics.Method: Searches were made in PubMed, Web of Science, Scopus, Cochrane,and Embase, according to PRISMA guidelines. There were no time or publicationtype restrictions. Studies that met the inclusion criteria were read in full text andresulted in 44 included articles. Quality assessment and risk of bias (RoB) wereperformed using checklists by AMSTAR-2 and ROBIS.Results: The four main recommended measures for IPC in dentistry were: triage,personal protective equipment, antimicrobial mouthwash before the procedure,and surface disinfection. Most of the included studies were literature reviews withlow quality and a high RoB.Conclusion: Measures taken during this pandemic were based on evidence,previous knowledge, and subjective opinions. However, there were limitations inthe included studies as their evidence was of lower quality and had a high RoB.Future research is needed to minimize the risk of infection spreading in dentistryduring the pandemic. The lack of research on SARS-COV-2 was considered aknowledge gap that should be addressed to be used effectively in futurepandemics. This present study shows that IPC policies were to some extent basedon evidence but not regarding the current virus. / Syfte: Syftet med studien var att bedöma och sammanställa nuvarandekunskapsläget samt rekommendationerna för infektionspreventionen och kontroll(IPC) inom tandvården under COVID-19 pandemin. Vidare var syftet attgenomföra en bedömning av huruvida tidigare kunskap om infektionspreventionhar bidragit till att konstruera evidensbaserade åtgärder för infektionspreventionsom kan bli universellt applicerbara. Dessutom, att identifiera kunskapsluckorsom behöver åtgärdas gällande infektionsprevention och kontroll för att effektivtkunna användas för framtida pandemier.Material och metod: Sökningar gjordes i PubMed, Web of Science, Scopus,Cochrane och Embase, enligt PRISMA riktlinjer. Det fanns inga tids- ellerpublikationstypsbegränsningar. Studier som uppfyllde inklusionskriterierna lästesi fulltext och resulterade i 44 inkluderade artiklar. Kvalitetsbedömning och riskenför bias av de inkluderade studierna utfördes med hjälp av checklistor avAMSTAR-2 och ROBIS.Resultat: De fyra främsta rekommenderade åtgärderna för IPC inom tandvårdenvar: triage, personlig skyddsutrustning, antimikrobiell munsköljning föreproceduren samt ytdesinfektion. De flesta av de inkluderade studierna varlitteraturöversikter med låg kvalitet och hög risk för bias.Slutsats: Åtgärder som vidtogs under denna pandemi baserades på både bevis ochtidigare kunskap men också subjektiva åsikter. Det fanns dock begränsningar i deinkluderade studierna på grund av att deras evidens inte var av god kvalitet samthade en hög RoB. Framtida forskning behöver göras för att minimera risken förinfektionsspridning inom tandvården under COVID-19-pandemin. Brist påforskning om SARS-COV-2 ansågs vara en kunskapslucka som måste åtgärdasför att effektivt kunna användas för framtida pandemier.

Objectives: To develop and validate a survey that can be used to measure key infection prevention and control (IP&C) structures and processes in LTC facilities. Methods: This study was designed using a three-phase methodology. In Phase I, six structural and process composite indices were developed based on the 2004 PHAC recommendations for IP&C in LTC and other literature. During the second phase of the study, a group of 7 experts in LTC IP&C used the Delphi methodology to validate and further develop the survey based on group consensus. Five Safety Principles published by the Institute of Medicine were also provided to the experts so they could be used to complement and further develop the concepts covered by the survey. The Delphi phase began in April and ended in October 2007; 114 worksheets were sent to experts to support the consensus-reaching process. Once the validity of a survey draft had been established based on expert-group consensus, it was pilot-tested in Phase III using 20 randomly selected LTC facilities in Fraser Health. Findings: The three-phase methodology used in this study was very useful and innovative way to further develop and validate the literature-based survey developed in Phase I for IP&C in long term care. In addition, by merging two bodies of knowledge and thought into the process, concepts and components that are not explicitly described in IP&C literature yet were felt to be key in program success, were incorporated into the measurement tool. Using Delphi, the experts expressed a need for IP&C professionals working in LTC to increase their knowledge, understanding and use of safety theory and strategies. They also felt that interdisciplinary work, the development of a culture of safety, and the development clear and simple IP&C systems are key ways in which infections can be prevented and outbreaks quickly controlled. In Phase III, the pilot-study analysis demonstrated the utility, validity and reliability of the survey. In addition, the analysis showed that there is a tendency for facilities to have lower levels of components within the Leadership Index and the ICP Index.

There is an increase in HIV/AIDS and other blood borne diseases. Health care workers are often exposed to blood and body fluids and thus prone to blood borne infections. Preventative measures can be taken to prevent health workers from contracting these diseases. However, health care workers need to stringently apply these measures. Universal precautions against blood borne infections include diligent hygiene practices, such as hand washing and drying, appropriate handling and disposal of sharp objects, prevention of needle stick or sharp injuries, appropriate handling of patient care equipment and soiled linen, environmental cleaning and spills management, appropriate handling of waste as well as protective clothing such as gloves, gowns, aprons, masks and protective eyewear. This study is aimed at investigating compliance with universal precautions in operating theatres in Northern KwaZulu–Natal as well as perceptions of registered nurses working in these operating theatres regarding factors influencing compliance in order to contribute to measures to limit the risk of infection to patients and health care workers. A sequential explanatory design, mixed–method (quantitative and qualitative) was used to explore the use of universal precautions in operating theatres in the Northern Kwa–Zulu Natal. In the first phase, the sample consisted of practices in operating theatres of six hospitals and one regional hospital in area 3 of Kwa–Zulu Natal. The adapted structured checklist based on an established document developed by the MASA Committee for Science and Education (1995) was pilot tested. The collected data was statistically analysed and interpreted with the help of a statistician using SPSS. The results of Phase 1 were used as a base for the Phase 2 questions. Three focus group interviews were conducted with professional nurses who were observed during Phase 1 at the selected hospitals. Findings from quantitative data show that although health care workers take precautions to prevent infections, they do not attain full compliance to universal precautions. The qualitative data indicated that the reasons for non–compliance amongst others were the lack of knowledge of universal precautions, communication factors, resources, including maintenance of equipment, lack of supplies and shortage of human resources and attitudes of health care workers. / Thesis (M.Cur.)--North-West University, Potchefstroom Campus, 2012.

There is an increase in HIV/AIDS and other blood borne diseases. Health care workers are often exposed to blood and body fluids and thus prone to blood borne infections. Preventative measures can be taken to prevent health workers from contracting these diseases. However, health care workers need to stringently apply these measures. Universal precautions against blood borne infections include diligent hygiene practices, such as hand washing and drying, appropriate handling and disposal of sharp objects, prevention of needle stick or sharp injuries, appropriate handling of patient care equipment and soiled linen, environmental cleaning and spills management, appropriate handling of waste as well as protective clothing such as gloves, gowns, aprons, masks and protective eyewear. This study is aimed at investigating compliance with universal precautions in operating theatres in Northern KwaZulu–Natal as well as perceptions of registered nurses working in these operating theatres regarding factors influencing compliance in order to contribute to measures to limit the risk of infection to patients and health care workers. A sequential explanatory design, mixed–method (quantitative and qualitative) was used to explore the use of universal precautions in operating theatres in the Northern Kwa–Zulu Natal. In the first phase, the sample consisted of practices in operating theatres of six hospitals and one regional hospital in area 3 of Kwa–Zulu Natal. The adapted structured checklist based on an established document developed by the MASA Committee for Science and Education (1995) was pilot tested. The collected data was statistically analysed and interpreted with the help of a statistician using SPSS. The results of Phase 1 were used as a base for the Phase 2 questions. Three focus group interviews were conducted with professional nurses who were observed during Phase 1 at the selected hospitals. Findings from quantitative data show that although health care workers take precautions to prevent infections, they do not attain full compliance to universal precautions. The qualitative data indicated that the reasons for non–compliance amongst others were the lack of knowledge of universal precautions, communication factors, resources, including maintenance of equipment, lack of supplies and shortage of human resources and attitudes of health care workers. / Thesis (M.Cur.)--North-West University, Potchefstroom Campus, 2012.

Objectives: To develop and validate a survey that can be used to measure key infection prevention and control (IP&C) structures and processes in LTC facilities. Methods: This study was designed using a three-phase methodology. In Phase I, six structural and process composite indices were developed based on the 2004 PHAC recommendations for IP&C in LTC and other literature. During the second phase of the study, a group of 7 experts in LTC IP&C used the Delphi methodology to validate and further develop the survey based on group consensus. Five Safety Principles published by the Institute of Medicine were also provided to the experts so they could be used to complement and further develop the concepts covered by the survey. The Delphi phase began in April and ended in October 2007; 114 worksheets were sent to experts to support the consensus-reaching process. Once the validity of a survey draft had been established based on expert-group consensus, it was pilot-tested in Phase III using 20 randomly selected LTC facilities in Fraser Health. Findings: The three-phase methodology used in this study was very useful and innovative way to further develop and validate the literature-based survey developed in Phase I for IP&C in long term care. In addition, by merging two bodies of knowledge and thought into the process, concepts and components that are not explicitly described in IP&C literature yet were felt to be key in program success, were incorporated into the measurement tool. Using Delphi, the experts expressed a need for IP&C professionals working in LTC to increase their knowledge, understanding and use of safety theory and strategies. They also felt that interdisciplinary work, the development of a culture of safety, and the development clear and simple IP&C systems are key ways in which infections can be prevented and outbreaks quickly controlled. In Phase III, the pilot-study analysis demonstrated the utility, validity and reliability of the survey. In addition, the analysis showed that there is a tendency for facilities to have lower levels of components within the Leadership Index and the ICP Index.