Induced vibrations due to tire-pavement interaction are one of the main sources of vehicle exterior noise, especially near highways and main roads where traveling speeds are above 50 kph. Its dominant spectral content is approximately within 500-1500 Hz. However, accurate prediction tools within this frequency range are not available. Current methods rely on structural modeling of the complete tire using finite elements and modal expansion approaches that are accurate only at low frequencies. Therefore, alternative physically-based models need to be developed. This work proposes a new approach that incorporates wave behavior along the tire's circumferential direction, while modes are assumed along its transversal direction. The formulation for new infinite plate and cylindrical shell structural models of a tire is presented. These are capable of accounting for orthotropic material properties, different structural parameters between the belt and sidewalls, inflation pressure, and rotation of the tire. In addition, a new contact model between the pavement and the tire is developed presented. The excitation of the tire due to the impact of the tread-pattern blocks in the contact patch region is characterized and coupled to the structure of the tire. Finally, a Boundary Element Method is implemented in order to compute the vibration-induced noise produced by the tire. All the modeling components are combined in a single prediction tool named Wave Pro Tire. Lastly, simulated responses and validation cases are presented in terms of harmonic responses, Frequency Response Functions (FRF), and produced noise. / Doctor of Philosophy / Induced vibrations due to tire-pavement interaction are one of the main sources of vehicle exterior noise, especially near highways and main roads where traveling speeds are above 50 kph. Accurate prediction tools are not currently available. Therefore, new physically based models need to be developed. This work proposes a new approach to model the tire’s structure with a formulation that accounts for multiple physical phenomena. In addition, a model that simulates the contact between the pavement and the tire’s tread is presented. Finally, the vibrations are coupled to the produced noise in a single prediction tool named Wave Pro Tire. This work also includes simulated responses and validation cases.