This study analyzed the effects of acculturation, locus of control, and incidence of inhalant use on Mexican Americans. Information was collected from 275 subjects at three middle schools and one treatment center. The instrument consisted of Levenson's Locus of Control Scale, the Acculturation Rating Scale for Mexican Americans, and an incidence of use and family relationship questionnaire developed for this study. Statistical analysis indicated a relationship between acculturation and inhalant use. Further examination revealed relationships between a family members' use and subjects' inhalant use; subjects' alcohol use and inhalant use; and subjects' marijuana use and inhalant use. Information implied that prevention and intervention programs should focus on children of substance users and further research is needed surrounding the role of acculturation.