Thesis--Rostock.

Thesis (Ph. D.)--University of Wisconsin--Madison, 1983. / Typescript. Vita. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references (leaves 187-190).

Thesis (Ph. D.)--University of California, Los Angeles, 2004. / Vita. Includes bibliographical references (leaves 245-249).

Thesis (doctoral)--Universität Breslau.

International Telemetering Conference Proceedings / October 17-20, 1994 / Town & Country Hotel and Conference Center, San Diego, California / The Space Station Verification and Training Facility is using an object-oriented design methodology for software design, a rate monotonic scheduling and message passing system to support the highly distributed environment, and the Ada language to implement most of the software. One of the subsystems within the Space Station and Training Facility is the Space Network Simulator. Space Network simulators are used to provide training of ground controllers and flight crews, providing a model of real-world formats and protocols. This gives the controller the appearance of a real-world network, providing valuable training. To develop a simulation of the space network within this distributed environment, software objects are under development to dynamically simulate the existence of the space vehicle(s) and their communication components. Communication components include the on-board antennas, transponders, communication systems, and corresponding communication ground control facilities. Telemetry systems are used in the simulation to provide the control of actual data manipulation, as a function of the state of the simulated Space Network. The telemetry system automatically formats appropriate telemetry characteristics through mode and control commands. A software model is under development to provide a transparent interface between the software objects and the telemetry system, allowing the objects to execute without knowledge of the particular telemetry system in use. A transparent interface between the software and hardware, within this object-oriented methodology, reduces the propagation of change to software models as the interface requirements change.

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Peroxisomes are indispensable organelles that perform many essential metabolic activities. Thus, eukaryotic cells have evolved molecular mechanisms to ensure the inheritance of peroxisomes from mother cell to daughter cell at cell division. In the budding yeast Saccharomyces cerevisiae, the class V myosin motor, Myo2p, interacts with its peroxisomal receptor, Inp2p, to move peroxisomes along actin from mother cell to bud, while the peroxisomal membrane protein Inp1p functions to tether peroxisomes to the cell cortex. In this thesis, I report the results of investigations of peroxisome inheritance using the dimorphic yeast Yarrowia lipolytica as a model system. We showed that peroxisome mobility and inheritance are dependent on actin in Y. lipolytica. Interrogation of the Y. lipolytica genome revealed one class V myosin. This myosin V is involved in transporting peroxisomes from mother cell to bud. We characterized YlInp1p, the othologue of S. cerevisiae Inp1p, as the first peroxisomal protein required for peroxisome inheritance in Y. lipolytica. We demonstrated that YlInp1p functions to anchor peroxisomes in both mother cell and bud. YlInp1p has an additional role in the dimorphic transition from the yeast form to the hyphal form in Y. lipolytica. We identified Pex3Bp, a paralogue of Pex3p, as the peroxisome-specific receptor for myosin V in Y. lipolytica. Pex3Bp interacts directly with the globular tail of myosin V. Pex3Bp also interacts with itself and with Pex3p. In cells lacking Pex3Bp, peroxisomes are preferentially retained in the mother cell, while the majority of peroxisomes gather and are transferred to the bud in cells overproducing Pex3Bp. Overexpression of PEX3 can partially complement the phenotype of pex3B cells, while overexpression of PEX3B cannot complement the phenotype of pex3 cells. Interestingly, Pex3p, which has been shown previously to function in the de novo formation of peroxisomes from the ER, also interacts directly with the globular tail of myosin V. Therefore, Pex3p is involved in peroxisome inheritance. In addition, cells lacking Pex3Bp contain hyperelongated, tubulo-reticular peroxisomes, indicating that Pex3Bp has a role in peroxisome morphology. Our findings suggest that both Pex3Bp and Pex3p are multifunctional proteins that are involved in different steps of the peroxisome biogenic cascade.

Thesis (Ph. D.) in English--University of Maine, 2003. / Includes vita. Includes bibliographical references (leaves 229-236).