This thesis contains literary studies about plastics and injection of plastics including tools for the injection. Practical part of the thesis is focused on design manufacturing of plastic cover of drill. Manufacturing parameters, design construction of injection form, selected injection machine and technical economic evaluation are solved within the manufacturing proposal.

Performance-related musculoskeletal disorders in musicians are common due to the biomechanics required in their craft. Unfortunately, injuries can cause many to abandon music, so determining the best approach to treatment and prevention is key. This case study’s importance is to evaluate the optimal approach to carpal tunnel syndrome in a drummer. The patient is a 55-year-old male full-time drummer with a history of diabetes mellitus and osteoarthritis, who presented to clinic with chronic bilateral hand numbness and tingling that had been present for years. The location of the symptoms were mainly in the palmar aspect of the 1st digit, 2nd digit, 3rd digit, and the radial side of the 4th digit. The symptoms had progressively been worsening, and his discomfort was initially rated at a 10/10 bilaterally. He had tried over-the-counter and prescription anti-inflammatory medications as well as braces without improvement. His physical exam was positive for Tinel’s sign. The diagnosis of carpal tunnel syndrome was eventually made. The patient was treated with bilateral ultrasound-guided carpal tunnel injections with lidocaine and methylprednisolone. The other component of treatment was relative rest, which allowed us to tailor treatment to his drumming. After treatment, his discomfort was rated at 0/10 bilaterally, and he was drumming without issue. It was found that relative rest and carpal tunnel injections are effective in treating carpal tunnel syndrome in drummers. His treatment was tailored to his specific instrument type, which was a key component to the success. Upon review, there is limited to no specific information on treating drummers as a specific group in the literature, but rather more information on treating musicians as a whole. Different instrumentalists have different postures and repetitive movements, so future studies would do well to examine the individual biomechanics of the different instrumentalists to better tailor treatment and prevention.

During a healthcare visit, children report fear of injections. Virtual Reality (VR) has been identified as a possible tool that can help decrease pain associated with receiving injections. The purpose of this study was to examine the effects of VR on decreasing pain children experience when receiving an injection. Children, 4 to 12 years old, were randomly assigned to either a VR group or a control group. In the intervention group, children engaged in VR before and during their injection as a tool for distraction.The control group received standard care. Pain was assessed through self-report, parent observations, and researcher observations. Children who experienced VR distraction displayed significantly less pain, as observed by both parents and an observer. VR appears to be an effective tool to help minimize pain in pediatric patients experiencing an injection. Therefore, pediatricians should consider providing VR as a distraction during injections.

Abstract: This thesis aims to contribute to the development of the isobaric combustion engines by exploring multiple injection strategies, by means of computational simulations using a commercial software Converge. A single injection case validated with experimental data in terms pressure trace and heat release rate was used as a baseline reference. The adjustment of the turbulent kinetic energy dissipation constant is found to have the most significant influence in reproducing the pressure and heat release rate histories observed in the experiment. As a first attempt to achieve isobaric combustion, a multiple injection strategy using a single injector was explored with up to four consecutive injections. Considering that the computational simulations were unable to reproduce the experimental data due to a number of uncertainties in the implemented models, the present study attempted to identify the main causes of the discrepancies through various parametric studies. First, different liquid fuel properties were examined and it was found that, while the physical properties of the fuels have a notable effect in terms of evaporation and atomization, such variations were not sufficient to reproduce the experimentally observed heat release cycle. Next, the effects of the uncertainties in the kinetic mechanisms were assessed by the reaction multiplier, an artificial adjustment of the rate constants, and it was found that the reaction multiplier affected the ignition of the first injection, but not the subsequent injection events. As such, the use of reaction multipliers to reproduce the experimental data was found to be unsuccessful. The effect of thermodynamics properties was also examined by employing real-gas equations of state, such as Redlich-Kwong and Peng-Robinson, and the results showed little difference at the conditions under consideration. Finally, advancing the start of injection was found to have the most significant effect on pressure trace and heat release rate to lead to a substantial improvement in the numerical prediction. The results suggest that the key uncertainties in modeling of the present engine combustion are likely the accurate timing of the start of injection combined with the exact injection rate shape profile.

The midcontinent United States, a region which typically does not experience many earthquakes, has experienced a significant increase in the number of earthquakes over the last decade. This increase in earthquake activity has been linked to wastewater injection, a process in which large volumes of wastewater from oil and gas extraction are injected into deep (2-3 km), high-permeability sedimentary rocks, near low-permeability Precambrian (>540-million-year-old) crystalline ‘basement’ rocks. The contact between these two rock types is referred to as the Precambrian nonconformity. Injection-induced earthquakes occur on or near basement-hosted faults due to an increase in pore fluid pressures, which implies that there may be a hydrological connection between the basement-hosted faults and the injection point. We hypothesize that the Precambrian nonconformity greatly influences this hydrological connection. We investigate the geologic properties of Precambrian nonconformity zone outcrop and core analogs to examine how the geology of the nonconformity zone controls fluid flow. Methods include mapping of geological materials and deformation structures (faults and fractures), mineralogical analysis, and geochemical analysis. These data sets allow us to infer the nature of fluid flow in the past, and make predictions about fluid flow in the future. In addition, this information is used to inform hydrological models, improving the ability to predict earthquakes due to wastewater injection. We identify three main geological scenarios that are likely to be encountered at the nonconformity. These are: 1) basal conglomerate, 2) weathered/altered horizon, and 3) mineralized contacts. These scenarios, or combinations of these scenarios, may be fractured or faulted, resulting in a variety of hydrological implications. The permeability of basal conglomerates and weathered horizons at the contact depends on the textures and minerals that are present. Regolith, clast-supported granitic wash, or poorly cemented conglomeratic horizons, may act as high permeability conduits, whereas a clay-rich grus or granitic wash, or tightly cemented conglomerate, may act as low permeability barriers. Mineralized contacts may act as low permeability barriers due to a reduction of pore space. The mineralized contact shows that the introduction of warm brines by modern injection may result in mineralization or chemical weathering, dynamically affecting permeability over time depending on the mineralogy of the host rock and chemical composition of the injected brine.

Malicious software, or malware, is often employed as a tool to maintain access to previously compromised systems. It enables the intruders to utilize system resources, harvest legitimate credentials, and maintain a level of stealth throughout the process. During incident response, identifying systems infected with malware is necessary for effective remediation of an attack. When analysts lack sufficient indicators of compromise they are forced to conduct a comprehensive examination to identify anomalous behavior on a system, a time consuming and challenging task. Malware authors use several techniques to conceal malware on a system, with a common method being DLL injection. In this dissertation we present a system for automatically generating Windows 7 x86 memory images infected with malware, identifying the malicious DLLs injected into a process, and extracting the features associated with those DLLs. A set of 3,240 infected memory images was produced and analyzed to identify common characteristics of malicious DLLs in memory. From this analysis a feature set was constructed and two datasets were used to evaluate five classification algorithms. The ZeroR method was used as a baseline for comparison with accuracy and false positive rate (misclassifying malicious DLLs as legitimate) being the two metrics of interest. The results of the experiments showed that learning using the feature set is viable and that the performance of the classifiers can be further improved through the use of feature selection. Each of the classification methods outperformed the ZeroR method with the J48 Decision Tree obtaining the, overall, best results.

Effects of the in ovo injection of Inovocox EM1 vaccine (EM1 vaccine) suspended in commercial diluent on developing broiler embryos were investigated in 3 trials. Effects of the EM1vaccine administered by in ovo injection on broiler embryogenesis and posthatch performance was determined by evaluating site of injection (SOI), embryo staging (ES), hatchability, and chick quality parameters. Oocyst output, microscopic lesion scores, and grow-out performance were further examined through day 35 posthatch. In these studies, it was shown that oocyst output began at day 3 posthatch (6 days post-injection), and peaked at day 7 posthatch (10 days post-injection). The EM1 vaccine had no effects on hatchability, various and chick quality parameters that were examined in the study. Similarly, grow-out performance through day 35 posthatch was not affected by the EM1 vaccine. SOI and ES provided information on the accuracy of in ovo vaccine delivery to the embryos, and were found to be significantly influenced by embryo age. In conclusion, in ovo injection of the EM1 vaccine has no detrimental effect on broiler embryogenesis, hatching chick quality, or the performance characteristics of Ross × Ross 708 broilers.

Variable-rate technologies coupled with broadcast spray systems serve to reduce chemical inputs, misapplication of chemicals, and environmental pollution, thus improving profitability and sustainability. Sprayer variable rate control involves using pulse width modulation (PWM) solenoids and/or direct chemical injection to adjust the application rate. The objectives of this research were to: outfit a conventional broadcast sprayer with PWM and direct inject technologies; evaluate the accuracy of the PWM system to control application rate for strait line and turn segments; and characterize the direct injection system’s transport delay time. For the PWM evaluation, the mean flow rate and coefficient of variation of individual nozzles indicated consistent performance. For the direct injection evaluation, the manufacturer recommended plumbing scheme and injection point location resulted in unsatisfactory delay times, ranging from 105 to 150s for the 8 km h-1 (5 mph) speed and 60 to 90s for the 16 km h-1 (10 mph) speed.

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Background: Hemophilia A is X-linked recessive congenital bleeding disorder. Exogenous infusion of FVIII is the treatment of choice in hemophilia A patients. However, inhibitor development remains the major problem in management of Hemophilia A. It has been showed that IVIG has immunomodulatory effects and it has been being used in the treatment of several autoimmune and inflammatory disorders. Here, we investigated the effect of co-administration of FVIII with IVIG on the development of inhibitor in naive and previously immunized hemophilia A mice. Methods: Initially, hemophiliac mice were immunized by weekly intraperitoneal injection of human recombinant FVIII (rFVIII). The mice then were treated, either by rFVIII/IVIG co-injection or rFVIII alone. In the other experimental group, naive hemophiliac mice were treated with rFVIII/IVIG co-injection for four weeks followed by injection of either rFVIII or rFVIII/IVIG. Plasma's anti-FVIII Ab titer was measured using ELISA. Results: Weekly injection of rFVIII led to the development of anti-FVIII Ab in all previously untreated mice. Treatment of those immunized mice with rFVIII/IVIG co-injection did not reduce the level of pre-existing Ab. On the other hand, naive mice treated with rFVIII/IVIG co-injection showed significantly less Ab titer compared to the mice received rFVIII alone after 4 weeks (mean Ab titre of 1 compared to 39, in rFVIII/IVIG co-injection and rFVIII groups respectively). Although the rFVIII/IVIG-treated mice developed immune response following the injection of rFVIII alone, Ab titer in those that kept receiving rFVIII/IVIG co-injection remained lower compared to other groups during the whole twelve weeks of the experiment. Conclusions: Co-injection of rFVIII with IVIG decreased the anti-FVIII immune response in previously untreated hemophilia A mice. These findings suggest that IVIG co-administration can be effective in management of hemophilia A patients at risk of inhibitor development. / Thesis / Master of Applied Science (MASc)