Burn injuries are one of the most painful and potentially debilitating traumatic injuries that a person can suffer. Every reader is likely to have, at some point in their life, suffered a burn injury, no matter how minor and therefore can have some comprehension of the pain and suffering associated with significant burn injury. Traumatic injury is the leading cause of death and disability in children and young adults. Although much has been done to optimise pre-hospital care and emergent treatment of injuries in recent times, the mainstay of managing death and disability from traumatic injury must lie in preventing these injuries where at all possible. To enable effective preventative strategies to be put in place it is important to define the demographics of those injured and the mechanisms of injury for any given population. Only then can we ensure that strategies are targeted in the areas where they are most needed at the mechanisms that are occurring most commonly. This study has combined a number of data sources namely burns service, fire service, coroners' service and accident and emergency department in an attempt to define the epidemiology and aetiology of burn injury in Greater Manchester. Data from the different sources was pooled and underwent a process of data-linkage to remove duplicate records. Rates have been calculated and compared according to age group, sex group and deprivation status. Poisson regression modelling was used to calculate the rate ratios amongst the different groups. Postcode data was used to allow geographical mapping of injuries across the county to allow rates to be calculated for different areas of the city. Where rates have been calculated for small area geographies Bayesian modelling was used to predict injury rates for those areas. Maps have been produced that show the areas with the highest rates of injury. The results show that in children it is the under five age group that have the highest rates of injury, particularly the under 2's. In adults, those over 75 years of age have the highest rates of injury. For all age groups males were more likely to be injured than females. In both children and adults higher rates of injury were seen in those areas where there were increased levels of deprivation. Key mechanisms of injury for individual age groups have been highlighted. The maps of Greater Manchester and its constituent local authorities show those areas with the highest rates of injury. The definition of target demographic groups and geographical areas within Greater Manchester will be used to allow development of targeted prevention strategies in those areas.

The purpose of this thesis was to develop a means of predicting future injury among nursing personnel working in a hospital system. Nursing has one of the highest incidence rates of musculoskeletal injuries among U.S. occupations. Endemic to the job are tasks such as rolling, sitting, standing, and transferring large, and often times, uncooperative patients. These tasks often place large biomechanical stresses on the musculoskeletal system and, in some cases, contribute to or cause a musculoskeletal injury. Given the current nursing shortage, it is imperative to keep nurses injury-free and productive so they can provide patient care services. Even though a large number of nursing personnel are injured every year and most are exposed to these high levels of biomechanical stress, the majority of nurses are injury-free. The question then arises "Why do some nurses have injuries while others do not?" The purpose of this thesis was to determine whether individual attributes in a population of nurses were associated with risk of future injury. The subject population was comprised of 140 nursing personnel at a local hospital system hired between April 1995 and February 1999. Data on individual attributes, such as patient demographics, previous injuries, posture, joint range of motion, flexibility, and muscular strength, was ascertained during a post-offer screening on these personnel. Twenty six (19%) nurses experienced an injury associated with the axial skeleton. Chi square test for homogeneity for the categorical predictor variables, and the Student's T-test for continuous predictor variables were used to determine if any individual attributes were associated with future injuries. None of the variables were associated with a risk of future axial skeletal injury. Practical application of these results for St. Joseph Regional Health Center, and possibly other acute care facilities, directs us to stop costly pre-employment/post-offer testing for the purpose of identifying injury prone nurse applicants. Secondly, it allows the focus of limited resources to be on making the job safer through administrative and engineering controls.

This study examines injury in competitive bodychecking and non-body checking youth ice hockey in male and female leagues in Ontario and Quebec. This study consisted of three parts: (1) quantifying the amount of injuries; (2) document situational factors in which hockey injuries occur; (3) observe play and interview parents to understand deeper subjective feelings towards injury and bodychecking. The research utilized a mixed method approach consisting of game observation, postgame injury assessments and semi-structured interviewing with parents. For this thesis, 56 games total were attended and only parents from the bodychecking team were interviewed. All games were video recorded through a dual camera video system. Game footage was then analyzed frame by frame to pinpoint injury locations, points of impact and situational factors surrounding the injury. Field-notes and interviews with parents allowed for a comprehensive look into the feelings and emotions surrounding injury and bodychecking. Results from the research revealed; 1) a disproportionately higher rate of injury in bodychecking hockey comparared to non-bodychecking male and female hockey; 2) an overwhelming percentage of injuries were the result of player and board contact; 3) majority of injuries occurred on legal play; and 4) parents support the concept of delaying bodychecking till later ages.

This study examines injury in competitive bodychecking and non-body checking youth ice hockey in male and female leagues in Ontario and Quebec. This study consisted of three parts: (1) quantifying the amount of injuries; (2) document situational factors in which hockey injuries occur; (3) observe play and interview parents to understand deeper subjective feelings towards injury and bodychecking. The research utilized a mixed method approach consisting of game observation, postgame injury assessments and semi-structured interviewing with parents. For this thesis, 56 games total were attended and only parents from the bodychecking team were interviewed. All games were video recorded through a dual camera video system. Game footage was then analyzed frame by frame to pinpoint injury locations, points of impact and situational factors surrounding the injury. Field-notes and interviews with parents allowed for a comprehensive look into the feelings and emotions surrounding injury and bodychecking. Results from the research revealed; 1) a disproportionately higher rate of injury in bodychecking hockey comparared to non-bodychecking male and female hockey; 2) an overwhelming percentage of injuries were the result of player and board contact; 3) majority of injuries occurred on legal play; and 4) parents support the concept of delaying bodychecking till later ages.

The purpose of this thesis was to develop a means of predicting future injury among nursing personnel working in a hospital system. Nursing has one of the highest incidence rates of musculoskeletal injuries among U.S. occupations. Endemic to the job are tasks such as rolling, sitting, standing, and transferring large, and often times, uncooperative patients. These tasks often place large biomechanical stresses on the musculoskeletal system and, in some cases, contribute to or cause a musculoskeletal injury. Given the current nursing shortage, it is imperative to keep nurses injury-free and productive so they can provide patient care services. Even though a large number of nursing personnel are injured every year and most are exposed to these high levels of biomechanical stress, the majority of nurses are injury-free. The question then arises "Why do some nurses have injuries while others do not?" The purpose of this thesis was to determine whether individual attributes in a population of nurses were associated with risk of future injury. The subject population was comprised of 140 nursing personnel at a local hospital system hired between April 1995 and February 1999. Data on individual attributes, such as patient demographics, previous injuries, posture, joint range of motion, flexibility, and muscular strength, was ascertained during a post-offer screening on these personnel. Twenty six (19%) nurses experienced an injury associated with the axial skeleton. Chi square test for homogeneity for the categorical predictor variables, and the Student's T-test for continuous predictor variables were used to determine if any individual attributes were associated with future injuries. None of the variables were associated with a risk of future axial skeletal injury. Practical application of these results for St. Joseph Regional Health Center, and possibly other acute care facilities, directs us to stop costly pre-employment/post-offer testing for the purpose of identifying injury prone nurse applicants. Secondly, it allows the focus of limited resources to be on making the job safer through administrative and engineering controls.

The Slit family of secreted proteins act as axonal repellents during embryogenesis. Slit2 via its receptor, Roundabout-1, also inhibits chemotaxis of multiple leukocyte subsets. Using static and microfluidic shear assays, we found that Slit2 inhibited multiple steps required to recruit circulating neutrophils. Slit2 blocked capture and firm adhesion of human neutrophils to and transmigration across inflamed primary vascular endothelial cells. To determine the response of Slit2 in renal ischemia reperfsuion injury, Slit2 was administered prior to bilateral renal pedicle clamping in mice. This led to significant decreases in both renal tubular necrosis score and neutrophil infiltration. Administration of Slit2 also prevented elevation of plasma creatinine following injury in a dose-dependent manner. Furthermore, administration of Slit2 did not increase hepatic bacterial load in mice infected with L.monocytogenes infection. Collectively, these data demonstrate Slit2 as an exciting therapeutic molecule to combat renal ischemia reperfusion injury without compromising protective host innate immune functions.

The Slit family of secreted proteins act as axonal repellents during embryogenesis. Slit2 via its receptor, Roundabout-1, also inhibits chemotaxis of multiple leukocyte subsets. Using static and microfluidic shear assays, we found that Slit2 inhibited multiple steps required to recruit circulating neutrophils. Slit2 blocked capture and firm adhesion of human neutrophils to and transmigration across inflamed primary vascular endothelial cells. To determine the response of Slit2 in renal ischemia reperfsuion injury, Slit2 was administered prior to bilateral renal pedicle clamping in mice. This led to significant decreases in both renal tubular necrosis score and neutrophil infiltration. Administration of Slit2 also prevented elevation of plasma creatinine following injury in a dose-dependent manner. Furthermore, administration of Slit2 did not increase hepatic bacterial load in mice infected with L.monocytogenes infection. Collectively, these data demonstrate Slit2 as an exciting therapeutic molecule to combat renal ischemia reperfusion injury without compromising protective host innate immune functions.

This study examines injury in competitive bodychecking and non-body checking youth ice hockey in male and female leagues in Ontario and Quebec. This study consisted of three parts: (1) quantifying the amount of injuries; (2) document situational factors in which hockey injuries occur; (3) observe play and interview parents to understand deeper subjective feelings towards injury and bodychecking. The research utilized a mixed method approach consisting of game observation, postgame injury assessments and semi-structured interviewing with parents. For this thesis, 56 games total were attended and only parents from the bodychecking team were interviewed. All games were video recorded through a dual camera video system. Game footage was then analyzed frame by frame to pinpoint injury locations, points of impact and situational factors surrounding the injury. Field-notes and interviews with parents allowed for a comprehensive look into the feelings and emotions surrounding injury and bodychecking. Results from the research revealed; 1) a disproportionately higher rate of injury in bodychecking hockey comparared to non-bodychecking male and female hockey; 2) an overwhelming percentage of injuries were the result of player and board contact; 3) majority of injuries occurred on legal play; and 4) parents support the concept of delaying bodychecking till later ages.

Background: Unintentional childhood injuries are ranked as the fourth leading cause of death in the United States, with an average of 31 million children each year arriving in hospital emergency departments across the nation with accidental trauma related injuries (CDC, 2016). Pediatric providers are in a key position to assess, identify, and implement interventions to improve the rates of unintentional injuries that occur within the pediatric population. Purpose: This study will examine pediatric providers’ knowledge of injury prevention and practice behaviors regarding educating families and/or caregivers regarding injury prevention, and the frequency that patients and/or caregivers are provided with safety education. Method: An evidence-based educational intervention regarding home and environmental safety measure was delivered during a Phoenix Children’s Hospital “Grand Rounds”. The data was collected using a pre-test and post-test survey to assess providers’ pre-knowledge of unintentional injury and their practice behaviors. Aim 1: (a) assess the knowledge of pediatric healthcare providers regarding home and environmental age-appropriate safety measures for children, (b) determine the practice behaviors of pediatric healthcare providers in educating patients and/or families regarding injury prevention, and (c) examine the frequency that patients and/or caregivers are provided safety education by their healthcare provider. Aim 2: To evaluate the impact of the educational session on provider knowledge regarding unintentional injury in children. Results: The McNemar test was used to analyze changes in providers scores from pre- to post-test. The level of significance was set at 0.05. The McNemar test revealed a significant increase in the providers’ knowledge of injury prevention between pre- and post-test in the following areas: providers’ definitions of injury; providers’ knowledge of the organization that developed the Children Risk Assessment; the approach providers take to educate caregivers about age-appropriate injury prevention measures in the infant/child home and environment; and examination of how often providers assess patient developmental age. Conclusion: The results of the study showed a statistically significant improvement in providers’ understanding of the prevalence of unintentional childhood injuries from pre- to post-test and the importance of providing patients and families with information that aid in their understanding of injury prevention and home environmental safety interventions.

This study examines injury in competitive bodychecking and non-body checking youth ice hockey in male and female leagues in Ontario and Quebec. This study consisted of three parts: (1) quantifying the amount of injuries; (2) document situational factors in which hockey injuries occur; (3) observe play and interview parents to understand deeper subjective feelings towards injury and bodychecking. The research utilized a mixed method approach consisting of game observation, postgame injury assessments and semi-structured interviewing with parents. For this thesis, 56 games total were attended and only parents from the bodychecking team were interviewed. All games were video recorded through a dual camera video system. Game footage was then analyzed frame by frame to pinpoint injury locations, points of impact and situational factors surrounding the injury. Field-notes and interviews with parents allowed for a comprehensive look into the feelings and emotions surrounding injury and bodychecking. Results from the research revealed; 1) a disproportionately higher rate of injury in bodychecking hockey comparared to non-bodychecking male and female hockey; 2) an overwhelming percentage of injuries were the result of player and board contact; 3) majority of injuries occurred on legal play; and 4) parents support the concept of delaying bodychecking till later ages.