The concept of knowledge management has become a critical issue in both academic and practical area. Organizations invest huge resources in knowledge management work in order to maintain long term competitive advantage. Therefore, how to use information technology to support knowledge management in an efficient way is a critical success factor in organizations adopting knowledge management. However, the running effect of knowledge management system does not achieve organizations¡¦ expectancy. The main reason is that knowledge management system is designed for unstable form of knowledge; developing information system in a structural way can not process this abstract knowledge effectively. For the reason, this research applies intelligent agent technique in developing knowledge management system, hoping to make use of intelligent agents¡¦ autonomy, communication ability, adaptability and mobility to raise the efficiency of knowledge management. This research analysis the general knowledge management works in order to find out the general knowledge management requirements. And then, this research also checks which requirements are suitable for intelligent agent to process. After integrating these requirements, this research proposes a complete intelligent agent based knowledge management system framework and a detail definition of each intelligent agent, and a set of message communication protocols between these intelligent agents.