Indiana University-Purdue University Indianapolis (IUPUI) / Autonomous Emergency Braking (AEB) system uses vehicle’s on-board sensors such as radar, LIDAR, camera, infrared, etc. to detect the potential collisions, alert the driver and make safety braking decision to avoid a potential collision. Its limitation is that it requires clear line-of-sight to detect what is in front of the vehicle. Whereas, in current V2V (vehicle-to-vehicle communication) systems, vehicles communicate with each other over a wireless network and share information about their states. Thus the safety of a V2V system is limited to the vehicles with communication capabilities. Our idea is to integrate the complementary capabilities of V2V and AEB systems together to overcome the limitations of V2V and AEB systems. In a V2V-AEB system, vehicles exchange data about the objects information detected by their onboard sensors along with their locations, speeds, and movements. The object information detected by a vehicle and the information received through the V2V network is processed by the AEB system of the subject vehicle. If there is an imminent crash, the AEB system alerts the driver or applies the brake automatically in critical conditions to prevent the collision. To make V2V-AEB system advance, we have developed an intelligent heart Monitoring system and integrated it with the V2V-AEB system of the vehicle. The advancement of wearable and implantable sensors enables them to communicate driver’s health conditions with PC’s and handheld devices. Part of this thesis work concentrates on monitoring the driver’s heart status in real time by using fitness tracker. In the case of a critical health condition such as the cardiac arrest of a driver, the system informs the vehicle to take an appropriate operation decision and broadcast emergency messages over the V2V network. Thus making other vehicles and emergency services aware of the emergency condition, which can help a driver to get immediate medical attention and prevent accident casualties. To ensure that the effectiveness of the V2V-AEB system is not reduced by a time delay, it is necessary to study the effect of delay thoroughly and to handle them properly. One common practice to control the delayed vehicle trajectory information is to extrapolate trajectory to the current time. We have put forward a dynamic system that can help to reduce the effect of delay in different environments without extrapolating trajectory of the pedestrian. This method dynamically controls the AEB start braking time according to the estimated delay time in the scenario. This thesis also addresses the problem of communication overload caused by V2V-AEB system. If there are n vehicles in a V2V network and each vehicle detects m objects, the message density in the V2V network will be n*m. Processing these many messages by the receiving vehicle will take considerable computation power and cause a delay in making the braking decision. To prevent flooding of messages in V2V-AEB system, some approaches are suggested to reduce the number of messages in the V2V network that include not sending information of objects that do not cause a potential collision and grouping the object information in messages.