<p> Preliminary experiments were conducted to evaluate a theoretical model for predicting temporal numerosity data. The model was based on a hypothetical central unit of duration. It described the gating of sequentially presented auditory pulses. Experiment 1 offered partial support for the prediction that events occurring within one unit 50 milliseconds in duration would be perceived as simultaneous. Results of Experiment 2 suggested that empty duration units occurring between sequential events would not affect number reported. The estimate of the unit was 60 milliseconds. Experiment 3, an attempt to improve methodology, suggested values of the unit of approximately 75 and 106 milliseconds.</p> <p> Inadequacies of the model were discussed. Control experiments were considered to eliminate such cues for discrimination as duration and intensity differences.</p> / Thesis / Master of Arts (MA)

Traditionally, pre-cracking has been performed under tension-tension loading, followed by a load reduction scheme to obtain fatigue crack growth rate data in the near threshold regime. These data have been shown to exhibit load history effects due to remote crack closure. An alternative test method has been developed to minimize these load history effects. This test procedure uses compression pre-cracking to initiate a crack, followed by constant amplitude loading to grow the crack to failure. Compression-compression (C-C) loading as a means of forming a starter crack for fatigue crack growth is a relatively new concept. Cracks grown under C-C loading emanate from the notch tip due to a tensile residual stress field formed during the unloading cycle. The subsequent constant amplitude steady-state crack growth is free of load history effects, after crack growth beyond several compressive plastic zone sizes, and therefore will give a better steady-state representation of the near-threshold regime. A more in-depth examination at this phenomenon is performed herein.

The effects of exercise intensity and duration on excess post-exercise oxygen consumption (EPOC) were examined. Eight males exercised in a thermoneutral environment at 60% of maximal aerobic power (V0₂ₘₐₓ) for 30 min and performed the same total work at 80% and 40% V0₂ₘₐₓ by varying exercise durations. In addition, 2 work bouts were performed at 60% VO₂ₘₐₓ for 90 and 60 min. A standardized meal was consumed 2 h post-exercise. Oxygen consumption (V0₂), respiratory exchange ratio (RER), rectal temperature (Tc) and heart rate (HR) were monitored on a control day and before, during and for 3 h following exercise. VO₂ was equivalent to control day values within 30 min post-exercise on each of the 5 d and no consistent relation between exercise condition and duration of EPOC was observed. When total post-exercise VO₂ was expressed relative to control values, differences were greatest during the first 30 min post-exercise. Total net caloric expenditure was small (32. 5-57.9 kcal) in all cases. RER tended to remain equivalent to control levels post-exercise, with intermittent elevations. Significant elevations in Tc were obtained until 60 to 150 min post-exercise. No significant exercise-related effects were noted for dietary induced thermogenesis or the cumulative effect of the 5 exercise bouts on resting metabolic rate. Although exercise over a wide range of intensities and durations resulted in a significant EPOC, in all cases it was of short duration and the total 3 h energy expenditure was small. Neither duration nor magnitude of EPOC was associated with post-exercise RER or Tc. / Thesis / Master of Science (MSc)

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In light of the current global prevalence of overweight and obesity, the associated health risks, and the continuing adoption of sedentary lifestyle, this thesis investigated some of the factors that contribute to exercise adherence, directly comparing high-intensity whole body interval training and continuous endurance training. 68 inactive university aged adults (Age: 21.4±3.4 yrs, BMI: 25.6±4.6 kg/m2, VO2peak 40.1±5.7 ml/kg/min) were randomized into one of three groups; a non-exercise control, whole body high intensity training, or continuous endurance training. Aerobic capacity measurements, time to completion trials, muscular endurance, and core strength measures were taken at pre, post and follow up testing sessions. Psychological questionnaires were also administered during exercise as well as throughout the study. Following the intervention both exercise groups demonstrated equivalent improvements in aerobic performance, with only the interval group experiencing improved muscular and core endurance. After the 2-month follow up testing sessions the interval group lost all aerobic and core adaptation, with endurance only experiencing a partial loss. This finding indicates that the interval group did not adhere to exercise at a level that was high enough to preserve the adaptations associated with training. This finding is further supported by the psychological factors measured throughout this study, including acute affect, enjoyment and intentions to engage in future exercise. / Thesis (Master, Kinesiology & Health Studies) -- Queen's University, 2013-10-31 15:08:15.524

Intensity modulated radiotherapy (IMRT) can potentially increase the dose delivered to liver tumours while sparing normal tissues from dose. More complex IMRT, with more modulation of the radiation beam is more susceptible to geometric and dosimetric uncertainties than simpler radiotherapy plans. Simple breath-hold liver IMRT using few radiation beam segments (<30) was investigated in 27 patients to determine the quality of treatment in terms of tumour dose coverage and normal tissue sparing as compared to index IMRT using >30 segments. In all 27 plans number of segments was reduced to <30 without compromising tumour coverage or normal tissue dose constraints, at the expense of dose conformity. Delivered tumour and normal tissue dose did not differ statistically between IMRT plans when accounting for treatment residual geometric error. This research supports considering the use of simple IMRT for treatment of liver cancer, except when loss of dose conformation is undesirable (i.e. very high doses).

The hyperbolic power-duration relationship for high-intensity exercise is defined by two parameters: an asymptote (critical power; CP) reflecting the highest sustainable rate of oxidative metabolism, and a curvature constant (W'), which indicates a fixed amount of work that can be completed above CP (W>CP). According to the CP model of bioenergetics, constant work rate exercise above CP depletes the capacity-limited W' with fatigue occurring when W' is completely expended. The complete depletion of W' has been reported to occur when VO2max is attained and a critical degree of muscle metabolic perturbation (decline of finite anaerobic substrates and accumulation of fatigue-related metabolites) is reached. However, while the CP model is effective at predicting metabolic perturbation and the tolerable duration of severe-intensity constant work rate (CWR) exercise, it is unclear if metabolic perturbation and exercise performance can be explained by the CP model when different methods of work rate imposition are applied. Therefore, the purpose of this thesis was to: 1) investigate the efficacy of the CP concept to predict performance in exercise tests using different work rate forcing functions; and 2) explore whether the physiological bases for W' are consistent across different methods of work rate imposition. In study 1, compared to severe-intensity CWR exercise, the tolerable duration of intermittent severe-intensity exercise with heavy- (S-H) moderate- (S-M) and light-intensity (S-L) ‘recovery’ intervals was increased by 47%, 100% and 219%, respectively. W>CP (W') was significantly greater by 46%, 98%, and 220% for S-H, S-M and S-L, respectively, when compared to S-CWR, and the slopes for the increases in VO2 and iEMG were progressively lowered as the recovery work rate was reduced. In study 2, both the VO2max and W>CP were similar across incremental cycling protocols that imposed a fixed ramp rate and cadence (4.33 ± 0.60 L•min-1; 14.8 ± 9.2 kJ), a fixed ramp rate with cadence self-selected by the subjects (4.31 ± 0.62 L•min-1; 15.0 ± 9.9 kJ) and a step incremental test where subjects were instructed to select power output according to prescribed increments in ratings of perceived exertion (4.36 ± 0.59 L•min-1; 13.0 ± 8.4 kJ). In study 3, the VO2max and W>CP were also not different across a 3 min all-out cycling test (4.10 ± 0.79 L•min-1; 16.5 ± 4.0 kJ), cycling at a constant work rate predicted to lead to exhaustion in 3 min until the limit of tolerance (4.20 ± 0.77 L•min-1; 16.6 ± 7.4 kJ) and a self-paced 3 min work-trial (4.14 ± 0.75 L•min-1; 15.3 ± 5.6 kJ). In study 4, after completing severe-intensity exercise (>CP) to exhaustion, muscle homeostasis ([PCr], pH, [ADP] and [Pi]) returned towards baseline and subjects were able to exercise for at least 10 min at a heavy-intensity work rate (<CP); however, when the work rate was lowered but remained in the severe-intensity domain (>CP), muscle metabolites ([PCr], pH, [ADP] and [Pi]) did not recover and exercise tolerance was severely limited (39 ± 31 s). Finally in study 5, during severe-intensity intermittent knee extension exercise, the tolerable duration of exercise was 304 ± 68 s when 18 s recovery was allowed and was increased by ~69% and ~179% when the intermittent recovery periods were extended to 30 s and 48 s, respectively. The increased exercise tolerance with longer recovery periods occurred in concert with increased W>CP (3.8 ± 1.0 kJ, 5.6 ± 1.8 kJ and 7.9 ± 3.1 kJ for the intermittent protocols with 18, 30 and 48 s of recovery, respectively) and a delayed attainment of critical intramuscular metabolite concentrations ([PCr], pH, [ADP] and [Pi]). Therefore, the results of this thesis demonstrate that fatigue during various high-intensity exercise protocols is influenced by the capacity to complete work above the CP (W') and that W' depletion is linked to the attainment of VO2max and the attainment of critical levels of intramuscular [PCr], pH, [ADP] and [Pi]. These findings suggest that the CP model can be adapted to predict the degree of metabolic perturbation and exercise performance across a range of exercise settings in humans.