Interpersonal functioning can be conceptualized as being comprised of social skills, connectedness, social cognition, and intimacy. A concept that is related to an examination of interpersonal functioning is experiential avoidance (EA), which can be defined as an unwillingness to experience or remain in contact with unpleasant private events through attempts to avoid or escape from these experience. An examination of EA and interpersonal functioning has not previously taken place. This study thus sought to fill that gap in the literature. The availability of a behavioral-oriented measure of interpersonal functioning aided in this investigation. The relationship of EA and interpersonal functioning to depression and anxiety were also examined, in order to evaluate their relative contributions to psychopathology. Overall, it was found that EA and interpersonal functioning were significantly related. However, the dimensions of EA varied in strength with respect to their relationships with interpersonal functioning. Further, it was found that interpersonal functioning predicted unique variance in both depression and anxiety, and partially mediated the relationship between EA and both anxiety and depression. These results might guide the development of treatment programs and add support to the use of treatments with trans-diagnostic targets.