This study was designed to determine the effectiveness of a clinical intervention program for reduction of pain and concomitant symptoms of anxiety, depression and hostility in individuals experiencing chronic pain. The program consisted of 36 weeks of supportive group therapy, education and sessions of progressive muscle relaxation induced hypnosis. Single subject research design was used to analyze the clinical effectiveness of treatment. Data was collected and compiled weekly. Serial position curves were generated for a Reported Pain Index, SCL-90-R Symptom Indices for Anxiety, Depression, Hostility and the SCL-90-R Global Severity Index. The three subjects were adults whose ages ranged from 39 to 65, with five or more years of chronic pain due to orthopedic or arthritic conditions. Qualitative analysis of the data indicated dramatic reductions in pain and secondary symptoms. Reductions in reported pain ranged from 17% to 31% with the mean pain reduction for the group of 20.6%. Reduction in the SCL-90-R Global Severity Index ranged from 13.1% to 49.4% with the mean reduction for the group of 36.1%. Reduction in depression ranged from 12.7% to 50% with the mean reduction for the group of 32.6%. Anxiety was reduced for two subjects with a slight increase of .02% for the third subject. Range of anxiety change was .02% increase to 59% reduction with a group mean reduction of 36.3%. Reduction in hostility ranged from 29.5% to 54.4% with a group mean reduction of 39.9%. Progressive muscle relaxation induced hypnosis contributed to further reduction of pain and secondary symptoms with reductions ranging from 4 to 49%. The results of this study show dramatic reductions in pain, depression, hostility and anxiety in chronic pain patients. These findings are not meant to be generalized to other populations, but may point the way for future research utilizing long-term therapeutic approaches and single subject research design.