TRIZ is a method that can be applied to analyze and solve engineering problem with contradiction effectively, but design problem does not easy to clarify. Thus, the purpose of the research is to propose a systematic methodology to make clear engineering problem and get just principles to design, designs of transmission system and frame of bicycle are the examples to explain. First, utilizing object tree method transform design question to better parameter, simultaneously the better parameter transformed to worse parameter. According to better and worse parameter suitable principles are selected with Contradiction Matrix and design transmission system of bicycle. Next, Inventive Principles is categorized by characteristic of design, and getting suite attribute. Thus, using asymmetry principle to design frame. Finally the Bottom Bracket be load force that deform magnitude is evaluating, and influence the result of position of tube of frame find out batter frame.