M.A. / The disorder known as Irritable Bowel Syndrome (IBS) is a clinical conundrum. Of chronic magnitude, this disorder of the gastrointestinal system affects up to 20% of the population in developed countries. Yet, it remains elusive in terms of its accurate definition and diagnosis, while its origins and etiology are unknown. To date, clinical confirmation of this disorder is complex and uncertain, while medical intervention has proven to be largely unsuccessful. Symptomatology relating to IBS varies widely and is not confined to the gastrointestinal tract. Diagnoses are made on the grounds of the manifestation of certain physical symptoms such as constipation, diarrhoea, abdominal pain and distension and disordered bowel habits. The role of psychological factors in the manifestation of IBS is controversial, although many clinicians postulate IBS to be a psychosomatic disorder due to the presence of many concomitant psychological features such as anxiety and depression. By all appearances, one of the most dramatic psychosocial concomitants of IBS is stress. Research has indicated that factors such as income, social support, life stress, psychological status, coping styles and personality all play a role in terms of whether the disorder develops and how successfully or adaptively the sufferer copes with his/her disorder. In terms of a research project undertaken by the Counselling and Research Centre for Gastroenterology under the auspices of the Department of Counselling Psychology at the Rand Afrikaans University, an exhaustive investigation into the physiological and psychological concomitants of IBS was conducted. As part of this endeavour to bring IBS to the attention of the medical profession, the public at large, and the individuals who suffer from this disorder, a number of individual studies were undertaken by MA (Psychology) students as part of the larger project. These researchers attempted to highlight various essential aspects associated with IBS, the focus of which included psychopathological features, stress, abuse, coping styles and strategies, defence mechanisms, personality factors and eating disorders. A second phase of this research project is currently in operation in order to provide remediation in the form of psychotherapy and stress management to the subjects who participated in the initial research project. The focus of the present treatise aims to provide an all-encompassing integration of the various research studies referred to above. Thereafter, on the basis of the data obtained from these studies, attention turns to the identification of a psychological profile with respect to the typical patient suffering from IBS. In accordance with the scientific demands of psychosocial research, a thorough review of the literature and various theoretical explanations of IBS were conducted as part of the integrative process. A number of theoretical models were considered in terms of their application to IBS, including the Digestive Disease model; the Psychiatric model; the Psychophysiological model; a Behavioural iii model; a Biopsychosocial model and a relatively recent newcomer, the Salutogenic Orientation proposed by Antonovsky, that offers an unusual approach to health and disease. In terms of the psychological profile mentioned above, the data demonstrated interesting findings. It was ascertained that the large majority of IBS patients are women, a finding that has been internationally verified. These women tend to be married with children, well-educated and employed on a full-time basis. The emotional status of the typical IBS patient reflects varying degrees of psychopathological tendencies, while her interpersonal relationships are characteristically unstable. Demonstrating high stress levels, the IBS patient tends to utilize inadequate coping skills, while these women also report using a maladapative defence mechanism to cope with the difficulties of their lives. Furthermore, personality traits such as introversion and neuroticism have been observed in these women. Lastly, it has been noted that the typical IBS patient exhibits certain aberrant eating patterns that are characteristic of women who are diagnosed as anorexic and/or bulimic. The IBS patient experiences her physical symptoms as severely disruptive and debilitating. Living in a very stressful and demanding world, she is lonely and isolated and shows the tendency to somatize her problems in the form of a disorder that is neither life-threatening, nor results in other more serious diseases, but which causes major distress in her life.

M.A. / Irritable bowel syndrome has the dubious honour of being one of the most widely researched, yet poorly understood gastrointestinal disorders. Vast amounts of research have been conducted into every facet of this disorder, yet the investigations yield results that are often contradictory and more conducive to complication than clarification. In light of the quote above, it becomes apparent that research into IBS has fulfilled the requirements for 'serious research', leaving medical practitioners and researchers with more questions than answers. Irritable bowel syndrome is a bowel disorder characterised by abdominal pain and either diarrhoea or constipation (Bennett, 1989). It is estimated to affect 8 to 15% of the population, and accounts for between 50% and 70% of referrals to gastroenterology clinics (Whitehead & Schuster, 1985). Such a common disorder should be well understood but it is not. In fact, there is little consensus amongst clinicians and researchers concerning the underlying cause of this syndrome. Organic causes which have been suggested include abnormal motor activity of the intestinal tract (Snape et al., 1976), abnormal gut hormone secretion and sensitivity (Ritchie, 1973, in Lynn & Friedman, 1993) and diet (Jones et al., 1982, in Corney et al., 1991). Many studies have also indicated that psychological factors are important and that patients with this syndrome are more neurotic, depressed or anxious than others (Hislop, 1971; Young et al., 1976). Research findings have tended to be contradictory, yet one common thread throughout the literature has been the role that stress seems to play in both the onset and maintenance of IBS. A number of studies have been conducted in this area, yet once again the findings have been contradictory and little clarity has been achieved. It is against this background that the aims of the present study can be described. The aims of the present study are twofold. The first, and most specific aim is to clarify the relationship between psychological stress and IBS. In particular, the present investigation will explore the differences in daily and occupational stress between healthy individuals and those suffering from IBS. The second aim of this research more general, and concerns theory building. This is particularly important in a field where there has been so much ambiguity and confusion.

published_or_final_version / abstract / Social Work and Social Administration / Doctoral / Doctor of Philosophy

M.A. / The purpose of this study was to ascertain whether patients suffering from irritable bowel syndrome (IBS) differed from non-IBS clients in terms of their coping styles. Gastrointestinal disorders are among the most common of all illnesses; half of the population suffers from acute gastrointestinal illnesses every year (Read, 1985). More than 10% have chronic illnesses, and these illnesses are a major cause of absenteeism from work. In view of this it is surprising that there is such a faucity of psychological and psychophysiological research focusing on gastrointestinal activity. Perhaps one reason for this is that investigators conceptualise the gastrointestinal tract as a system that is unresponsive to psychological intervention. Another reason may be the widespread belief that adequate techniques are not available for studying gastrointestinal psychology and psychophysiology (Haynes & Gannon, 1981). Today there is consensus that IBS is a psychosomatic disorder that accounts for between 40 to 70% of referrals to gastroenterologists. Unfortunately, this is a very misunderstood disorder. Sufferers are often misinformed or poorly educated by their physicians. Misunderstanding and lack of patient education often results in increased anxiety and physical distress. There are cases in which unnecessary surgery, expensive diagnostic procedures and addictive pain killers are mistakenly employed. In addition, IBS patients represent an expensive group because they use up a considerable amount of medical resources in money and time (Moser, 1986).

Doctor of Philosophy / Nineteenth century philosophy and anatomy regarded the nervous system as the only pathway of communication between the brain and body but now, research in the field of psychoneuroimmunology (PNI) has provided evidence to prove the age-old belief that there is a connection between the mind (or mental/emotional states) and the body. Researchers in PNI have now shown that the communication between the nervous and immune systems is bi-directional – i.e. there is a psychological reaction to physical disease and a somatic presentation of psychological disorders - and that the immune system, the autonomic nervous system, the endocrine system and the neuropeptide systems all communicate with each other by means of chemicals called messenger molecules or ligands. This paper outlines research into the treatment of Irritable Bowel Syndrome (IBS) with hypnotherapy, taking into account the mind-body connection and treating both the patient’s physiological and emotional/psychological symptoms rather than treating the physiological symptoms only. In other words, using a more holistic approach to the treatment of IBS. IBS is probably the most common functional gastrointestinal disorder encountered by both gastroenterologists and physicians in primary care. It is estimated that from 10% to 25% of the general population suffer from this condition and that it comprises about 30-50% of the gastroenterologists’ workload, yet the aetiology of IBS is unknown and, so far, there is no cure. Researchers are beginning to view IBS as a multi-faceted disorder in which there appears to be a disturbance in the interaction between the intestines, brain, and autonomic nervous system, resulting in an alteration in the regulation of bowel motility and/or sensory function. Most researchers agree that a subset of IBS sufferers have a visceral hypersensitivity of the gut or, more specifically, an increased perception of sensations in the gut. To date, studies of IBS have proposed previous gastroenteritis, small intestine bacterial overgrowth, psychosocial factors, a genetic contribution, and an imbalance of neurotransmitters as either possible causes or playing a part in the development of IBS. It is generally agreed that a patient’s emotional response to stress can exacerbate the condition. In section 1 of the thesis, the introduction, a detailed description and background appropriate to the study undertaken are provided, including aspects of epidemiology, diagnostic symptom criteria and clinical relevance of the Irritable Bowel Syndrome. Previous studies of various forms of treatment for IBS are discussed with the main emphasis being on treatment with hypnotherapy. All these therapies have concentrated on either mind or body treatments whereas this study demonstrates how hypnotherapy, and the use of imagery, addresses both mind and body. Finally, the rationale for the current study and the specific aims of the thesis are outlined. In section 2, the methodology and assessment instruments used in the clinical trial are discussed, as well as recruitment processes, research plan and timetable, and treatment schedule. Statistical analyses are provided and the main outcomes measures of the clinical trial, its limitations and scientific implications are addressed.

Doctor of Philosophy / Nineteenth century philosophy and anatomy regarded the nervous system as the only pathway of communication between the brain and body but now, research in the field of psychoneuroimmunology (PNI) has provided evidence to prove the age-old belief that there is a connection between the mind (or mental/emotional states) and the body. Researchers in PNI have now shown that the communication between the nervous and immune systems is bi-directional – i.e. there is a psychological reaction to physical disease and a somatic presentation of psychological disorders - and that the immune system, the autonomic nervous system, the endocrine system and the neuropeptide systems all communicate with each other by means of chemicals called messenger molecules or ligands. This paper outlines research into the treatment of Irritable Bowel Syndrome (IBS) with hypnotherapy, taking into account the mind-body connection and treating both the patient’s physiological and emotional/psychological symptoms rather than treating the physiological symptoms only. In other words, using a more holistic approach to the treatment of IBS. IBS is probably the most common functional gastrointestinal disorder encountered by both gastroenterologists and physicians in primary care. It is estimated that from 10% to 25% of the general population suffer from this condition and that it comprises about 30-50% of the gastroenterologists’ workload, yet the aetiology of IBS is unknown and, so far, there is no cure. Researchers are beginning to view IBS as a multi-faceted disorder in which there appears to be a disturbance in the interaction between the intestines, brain, and autonomic nervous system, resulting in an alteration in the regulation of bowel motility and/or sensory function. Most researchers agree that a subset of IBS sufferers have a visceral hypersensitivity of the gut or, more specifically, an increased perception of sensations in the gut. To date, studies of IBS have proposed previous gastroenteritis, small intestine bacterial overgrowth, psychosocial factors, a genetic contribution, and an imbalance of neurotransmitters as either possible causes or playing a part in the development of IBS. It is generally agreed that a patient’s emotional response to stress can exacerbate the condition. In section 1 of the thesis, the introduction, a detailed description and background appropriate to the study undertaken are provided, including aspects of epidemiology, diagnostic symptom criteria and clinical relevance of the Irritable Bowel Syndrome. Previous studies of various forms of treatment for IBS are discussed with the main emphasis being on treatment with hypnotherapy. All these therapies have concentrated on either mind or body treatments whereas this study demonstrates how hypnotherapy, and the use of imagery, addresses both mind and body. Finally, the rationale for the current study and the specific aims of the thesis are outlined. In section 2, the methodology and assessment instruments used in the clinical trial are discussed, as well as recruitment processes, research plan and timetable, and treatment schedule. Statistical analyses are provided and the main outcomes measures of the clinical trial, its limitations and scientific implications are addressed.

M.A. / The purpose of the study was to ascertain whether patients suffering from irritable bowel syndrome (IBS) differed from non- IBS clients in terms of their defense mechanisms. Although irritable bowel syndrome (IBS) is one of the most common gastrointestinal disorders encountered by primary care physicians and gastroenterologists, it is one of the least well understood. Part of the reason for this is the lack of real consensus of opinion regarding the nature of the complaint (Read, 1985). Today it is widely agreed that irritable bowel syndrome is a psychosomatic disorder, that is, a disorder of physiological functioning and anatomical structure, which are determined for most part by psychological factors (Lachman, 1972; Moser, 1986). Evidence linking psychological variables to gastrointestinal disorders is surprisingly sparse, and all too often confusing and contradicting. Such conflicting results probably reflect the many methodological weaknesses common to all areas of study (Bennett, .1989). Although evaluation of the impact of psychological interventions on both symptomatic and psychological relief has been pursued, its findings provide tangential support for the importance of psychological disorders. Nevertheless, these studies have shown a consistency of positive results not found in the etiological research (Read, 1985). Using a variety of techniques, most with the therapeutic goal of stress reduction, psychological therapy has been shown to produce. symptomatic relief, increase periods of remission, and to reduce the impact of stress resulting from severe symptomatic flare ups in IBS (Bennett, 1989). In .addition, most IBS patients may not identify their gut symptoms in psychological terms. Therefore, they inappropriately and repeatedly subject themselves to unnecessary, expensive and harmful medical procedures in search of an organic cause. Further research into the psychological factors of IBS, including the defense mechanisms underlying it may lead to a reduction in type of anxiety (Folkman, Lazarus, Gruen & DeLongis, 1986). The ways in which people cope with intense emotions may have a significant effect on their psychological and physical health. StresS factors and the suppression of emotions, for example through defense mechanisms, are thought to be especially relevant in the etiology and exacerbation of psychosomatic illness (Ogden & Von Sturmer, 1984). The role that defense mechanisms play in the development of IBS forms the cornerstone of the present research.

M.A. / The overall objective of the global research project of which the present study is a part, is to create a greater awareness and understanding of the association between physiology and psychology, specifically with regard to IBS. Investigations are being conducted into the contribution of such factors as stress, anxiety, depression, somatization, psychopathology. early sexual abuse and physical abuse to the development and management of IBS. The present study aims to assess the incidence of co-morbid psychopathology in patients with IBS as compared to the general population. 1.3.2 Specific Aims. The aim of the present study is to compare the incidence of concurrent psychopathology in a sample of white, female patients, aged from 25-55 years and diagnosed to have IBS, with the incidence of psychopathology in a sample of white female non-IBS controls aged 25-55 years. Of initial concern will be whether the results of this study confirm the findings of the numerous research projects which attest to the high incidence of comorbid psychopathology in patients with IBS (Chaudhary & Truelove, 1962; Liss et al., 1973; Young et al., 1976), or add support to the limited evidence that disputes these claims (Talley, Kramlinger et al., 1993; Thornton, McIntyre et al., 1990). The study then aims to consider whether the variable of gender has a significant effect on the incidence of co-morbid psychopathology in patients with IBS. As will be discussed in Chapter 3, most of the studies do not differentiate between male and female subjects even though this may well prove to be an important determining factor. As mentioned in section 1.2.1, there is a dearth of research in South Africa into IBS and, more specifically, into the incidence of co-morbid psychopathology and IBS. By restricting participants in this study to those of the white race, the aim of this study is to initiate a process in which the incidence of co-morbid psychopathology in IBS patients of all races will be assessed and compared. In addition, the present study aims to assess whether age and level of education are significant variables in determining the incidence of co-morbid psychopathology in patients with IBS. Inter-group comparisons will be made between three groups of patients with IBS divided first according to age and then according to level of education. Finally, the present study aims to be more methodologically sound than certain of the earlier research projects as reported in the literature. As will become clear in Chapters 2 and 3, a common thread running through much of the literature is the concern that the validity of results may be questionable due to methodological flaws in the design of certain research projects. Small sample size has been a problem in some studies (Liss et al., 1973; Young et al., 1976) whilst in others, the absence of a control group has limited the relevance of data (Liss et al., 1973). Furthermore, a diversity of measuring instruments have been used in the past with little if any standardisation or control of specific variables being assessed. The measuring instrument used in this study, namely the Personality Assessment Inventory (PAI), allows for an accuracy and comprehensiveness of assessment not found in many previous studies (see Chapter 6, section 6.2.1.4). The PAI assesses psychopathological trends in personality functioning. The word "psychopathology" will be used in this study as substitute for the phrase "psychopathological trends in personality functioning".

M.A. / Irritable bowl syndrome (IBS) is one of the common conditions referred to gastroentorologists, but one of the least understood. Part of the reason for this is the real lack of consensus of opinion regarding the nature of the complaint. The problem is confounded by the absence of objective disease makers, as well as the variation in symptom presentation. The term (IBS) describes a cluster of symptoms which include chronic abdominal pain and altered bowel habits (diarrhoea, constipation, or alternating diarrhoea and constipation) in the absence of a known structural cause for the symptom (Toner, Garfinkel, Jeejeebhoy, Scher, Shulhan & Di Gasbarro, 1990). The symptoms of IBS mimic those of many other gastrointestinal diseases and the challenge to medical doctors is to establish a confident diagnosis based on the symptomatology of the individual, without the need to carry out multiple investigations to eliminate organic disease of the bowel. The pathogenesis of a condition remains a mystery. Most doctors would not consider IBS to a 'proper" disease at all, but view it as a physiological alteration in intestinal function brought about by psychological disturbance (Read, 1985).