This study traces the four Isaianic references in Matthew 1-4 to identify their influence in the structure and theology of Matthew's Gospel. Isaiah distinctively contributes to the parallel nature of the narratives in the structure of Matthew 1-12 and particularly to the structural unity of Matthew 1-4. Further, the Abrahamic background in Isaiah contributes to Matthew's "Son of Abraham" motif. The second chapter identifies the placement of the Isaianic references in Matthew and offers an alternative view of Matthew's macrostructure. Similarly, the integral unity of Matthew 1-4 is supported by parallel themes and plotlines. The strategic placement of Isaianic references supports this proposed structure. The study proceeds with a chapter devoted to each of the four Isaianic references in Matthew 1-4. The study's intertextual methodology observes the reference's text form, Isaianic context, reference in Jewish sources, placement in the Matthean chapter, Matthean context, and a summary of Isaiah's structural and Christological influence. Two appendixes accompany the research: one identifies the Abrahamic background in Isaiah 1-12, and another reevaluates the premise of a new Moses typology in Matthew. Isaianic references influence the narrative parallelism in Matthew 1-4, highlighting the calling motif, and confirming the preaching ministry of John and Jesus. Theologically, the Isaianic references and allusions echo in Matthew 1-4 to inform Matthew's Son of Abraham Christology. As the Son of Abraham, Jesus recapitulates Israel's history, following the paradigm of the patriarch Abraham.