The goal of this research is to compare performance of three analysis methods and three optimization methods for core-megacolumn-outrigger, or CMO skyscrapers. The three analysis methods include a 1D stick analysis, 2D frame analysis, and 3D finite element analysis. The three optimization methods include a trial and error optimization, optimality criteria optimization, and genetic algorithm. Each of these methods was compared by applying an example CMO skyscraper. The 1D stick analysis proved to be the most accurate when compared with the 3D finite element results. The genetic algorithm was recommended as the best optimization method in this research. The 1D stick method in this thesis introduces a new analysis involving an outrigger modification factor. The comparison of these optimization methods for skyscrapers has not been reported in the literature.