The purpose of this research was to investigate the influence of applying an intrinsic decompressive pre-load to a particular dynamic stabilization device on the biomechanical response of the lumbar spine. The FlexSPAR, which supports this ability, was used as a test case. A finite element model of a full lumbar spine was developed and validated against experimental data, and tested in the primary modes of spinal motion. The model was used to compare five lumbar spine test cases: healthy, degenerate, implanted with a pre-loaded device, implanted with a device without a pre-load, and implanted with rigid fixators. Results indicated that a pre-loaded FlexSPAR led to improved disc height restoration and segmental biomechanics. Results also showed that a pre-loaded FlexSPAR led to less change in bone remodeling stimulus in comparison to the device without a pre-load and rigid fixators. This work shows that there is a potential to improve the performance of posterior dynamic stabilization devices by incorporating a pre-load in the device.