Previous research has provided evidence of relationships between vocational interests and other psychological variables. Test scores from the VPI and FIRO-B for 699 white male job applicants were subjected to multiple regression analyses to determine if individual interest scales could be predicted by particular configurations of interpersonal need scales. It was hypothesized that Enterprising, Realistic, and Investigative interests would be predicted by Inclusion and Control needs and Social interests by Inclusion, Control, and Affection needs. To control for effects of sample size, a smaller sample (n = 125) was randomly drawn from the original data and subjected to identical analyses. Results indicated only partial support for some hypotheses and revealed little common variance between the two domains.