No description available.

Thesis (M.S.)--University of Wisconsin, 1966. / eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references (leaves 100-104).

No description available.

Autophagy is the process that degrades cytosolic constituents into products that can be recycled for use in energy generation and other processes. The endoplasmic reticulum is responsible for the bulk synthesis of the phospholipid phosphatidylethanolamine (PE) via the CDP-ethanolamine pathway. The aim of the present study was to determine the role of PE synthesis and the CDP-ethanolamine pathway in autophagy. This objective was examined through the use of two novel models deficient in Pcyt2, a gene that encodes the rate-limiting enzyme CTP-ethanolamine cytidyltransferase (ET) in the CDP-ethanolamine pathway. PCYT2 knockdown in human fibroblast cells did not respond normally to starvation conditions that activate autophagy. Similarly, Pcyt2 knockout in mice showed differences in autophagy induction in/between muscle, liver, and adipose tissue based on metabolic state (fasting/feeding). Pcyt2 knockout mice display evidence of metabolic syndrome at an older age and experiments with these mice determined that there was an effect of age (healthy young mice versus obese older mice) on autophagy induction. It was concluded based on in vitro and in vivo studies that autophagy induction is affected by impairment to the CDP-ethanolamine pathway and subsequent PE synthesis.

Thesis (M.S.)--University of Wisconsin--Madison, 1961. / Typescript. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references (leaves 82-84).

Thesis (M.A.)--University of Wisconsin--Madison, 1982. / Typescript. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references (leaves 124-137).

Thesis (M.S.)--University of Wisconsin--Madison, 1962. / Typescript. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references (leaves 36-38).

No description available.

Thesis (M.A.)--Ohio State University, 1984. / Includes bibliographical references (leaves 161-165). Available online via OhioLINK's ETD Center

This thesis examines the Kennedy Administration's decision to propose comprehensive civil rights legislation in June, 1963. The work focuses on the relationship between the Kennedy brothers, particularly on Robert F. Kennedy's position as his brother's main adviser and his influence on the president's final decision to go forward with legislation. It begins by exploring the Kennedy's childhood, then traces the brothers' approach toward civil rights during the campaigns of 1952 and 1960, and concludes with an assessment of the Kennedy administration's civil rights policy during his presidency. The thesis puts special emphasis on a May, 1963 meeting between Robert Kennedy and an eclectic bi-racial group of intellectuals led by the novelist James Baldwin arguing that the meeting profoundly altered Kennedy's understanding of civil rights, ultimately transforming the Kennedy legacy regarding civil rights.