Background: The prevalence rate of Obstructive Sleep Apnea (OSA) has been increasing steadily over the past two decades. OSA is often misdiagnosed with other medical conditions, and there are several complications associated with OSA, such ashypertension, coronary artery disease, and cognitive problems, including higher rates of strokes and epilepsy. Further, dental complications may arise from being diagnosed with OSA, impacting overall systemic health. Patients suffering from OSA are more susceptible to developing dry mouth, thus increasing bacterial/fungal growth, leading to tooth decay and periodontal disease. There is currently a lack of data exploring OSA in College Students and the Oral Manifestations (symptoms or conditions linked in the oral cavity) related to having OSA. The present study investigated the relationship between OSA and Oral Manifestations among College Students. Methods: Approximately 230 college students from a large university were recruited to participate in our cross-sectional study. The Epworth Sleepiness Scale was used to screen for students at higher risk for OSA. Oral manifestations were also assessed by providing a survey/questionnaire for the students to list their dental history. Results: Overall, the prevalence of excessive daytime sleepiness was 24.9% in our sample, and males reported a higher percentage of excessive daytime sleepiness (31.0%) compared to females (23.7%). A statistically significant relationship was observed between ESS score and the previous use of orthodontic treatment(s) (chi-square with two degrees of freedom = 7.3277, p = 0.026), ESS and academic standing (chi-square with two degrees of freedom = 6.6348, p = 0.036), bruxism and academic standing (chi-square with two degrees of freedom = 7.4323, p = 0.006), recent cavity in the last two years and gender (chi-square with two degrees of freedom = 8.0029, p = 0.005), previous use of orthodontic treatment(s) gender (chi-square with two degrees of freedom = 4.9005, p = 0.027), and current or previous abnormal bite and gender (chi-square with two degrees of freedom = 4.4447, p = 0.035). No other statistically significant relationships were observed between ESS and dental health outcomes in our sample, or by subgroup. Conclusions: Findings from our study show that higher scores on the ESS are related to certain oral health indicators, with some notable differences by academic standing and gender. Future studies are needed that include a diverse sample of college students and incorporate a clinical measure of OSA in this population. Universities can take an active role in addressing OSA and related issues by launching health campaigns, raising awareness through workshops and seminars, and fostering a culture of proactive well-being among students and staff.