In the coming knowledge-based economy era, knowledge structure map (KSM) has becoming more and more important. If learners doing learning without the support of knowledge structure map, it will cause learning alone problem. In order to construct a real KSM, we targeted the MIS domain. By using the National Dissertation and Thesis Abstract System as input source, we first extract different research subjects from keywords and then calculate the relation strength between each keyword pairs. An automatic approach has been developed for constructing KSM for different periods of time. The constructed KSM can help learners to reduce learning alone and provide a good reference for new researchers to seek for related research directions. The proposed method can also be applied to enterprises. They can adopt this method to construct any specific KSM corresponding to their professional domain, the constructed KSM would help new employee to learn better. Furthermore, with the support of KSM, CEO can make a better decision as the KSM would contain internal and external competitive advantages about future directions.