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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
1

Possible thermoregulatory contributions of plasma B-endorphin during prolonged exercise in humans

Kelso, Thomas Benton January 1983 (has links)
Six adult male volunteers of similar body composition and physical fitness were tested to determine plasma immunoreactive β-endorphin (Piβ-EN) response under three conditions of exercise thermoregulatory stress. The experimental protocol consisted of 120 min of stationary upright cycling at 50% Vo₂max under conditions of neutral (24ºC, 50% RH)/euhydration (NE), hot (35°C, 50% RH)/euhydration (HE), and hot/dehydration (HD). Piβ-EN was measured by radioimmunoassay at -30 min, 0 min, and at 15 min intervals thereafter. Change in plasma volume (ΔPV) was measured to determine its effect on Piβ-EN concentration. Preexercise Piβ-EN levels averaged 23.7 ± 2.6 pg•ml⁻¹ in all conditions. The greatest Piβ-EN response occurred at 105 min in HD conditions when levels rose to 43.2 ± 6.9 pg•ml⁻¹. Exercise in HD and HE conditions resulted in significantly (p < 0.05) elevated Piβ-EN above levels observed in NE. ΔPV did not account for more than 10% of Piβ-EN changes at any interval. The Piβ-EN response pattern closely resembled rectal temperature changes in all conditions. These data suggest that conditions of increasing exercise thermoregulatory stress are associated with increasing peripheral β-endorphin concentration. / Master of Science

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