A theorem by Shah and Khatri [A.M.S. (1961) 321883-887] is extended to give the distribution of Q/X² , where Q is a positive definite quadratic form involving non-central normal variates and X² is an independently distributed chi-square variate. Conditions are given under which the distribution of this ratio reduces to that of non-central F. Kramer’s method for analysis of variance of a two-way classification with disproportionate subclass numbers is reviewed and shown to satisfy these conditions. Various functional forms of the non-centrality parameter for evaluating the power of his method are given. Additional algebraic and numerical results are obtained to compare the power of Kramer's method and the method of fitting constants (least squares) outlined by Yates [J.A.S.A. (1934) 24151-66]. A mnemonic rule, based on 310 randomly generated two-way classifications, is given for discriminating against use of Kramer’s method in situations where his method potentially may be very deficient in power as compared to the method of fitting constants. / Ph. D.