For the exponential response η_u = α + βe^γZ_u (u = 1,2,…,N) where α and β lie on the real line (-∞,∞), and γ is a positive integer; the designs are given which minimize the bias due to the inherent inability of the approximation function ŷ_u = Σ_j=0<sup>d</sub>b_je^jZ_u to fit such a model. Transformation to η_u = α + βx_u^γ and ŷ_u = Σ_j=0<sup>d</sub>b_jx_u^j facilitates the solution for minimum bias designs. The requirements for minimum bias designs follow along lines similar to those given by Box and Draper (J. Amer. Stat. Assoc., 54, 1959, p. 622). The minimum bias designs are obtained for specific values of N with a maximum protection level, γ_d*(N), for the parameter γ and an approximation function of degree d. These designs obtained possess several degrees of freedom in the choice of the design levels of the x_u or the Z_uu , which may be used to satisfy additional design requirements. It is shown that for a given N, the same designs which minimize bias for approximation functions of degree one also minimize bias for general degree d, with a decrease in γ_d*(N) as d increases. In fact γ_d*(N) = γ₁*(N) - d + 1, but with the decrease in γ_d*(N) is a compensating decrease in the actual level of the minimum bias. Furthermore, γ_d*(N) increases monotonically with N, thereby allowing the maximum protection level on 1 to be increased as desired by increasing N. In the course of obtaining solutions, some interesting techniques are developed for determining the nature of the roots of a polynomial equation which has several known coefficients and several variable coefficients. / Ph. D.