<p>Skin temperature is detected through signals in unmyelinated C-fibers and thin myelinated Aδ-fibers in the peripheral and central nervous system. Disorders in thin nerve fibres are important and not rare but difficult to diagnose by the most common neurophysiological methods. In this pilot study different methods for quantitative sensory testing, QST, were compared to give some ideas about which method could be the most efficient to use in order to point out injuries of the sensory system in clinical practice. The comparison was made between Békésy (separate warmand cold thresholds) and Marstock test (combined warm and cold thresholds). The study also included the test persons estimations of the difficulty to perform the tests.</p><p>The study showed that there was no practical difference between the tests and that the test persons estimations did not show any indications that the methods differed in rating of difficulty. Our study did not give reason to stop measuring warm and cold detection thresholds separately, which is the international standard and have some theoretical advantages. We also compared detection thresholds for hand and foot, warmth and cold and for both slow and fast temperature changes to enlighten factors that could affect our measuring data.</p>

Operating speed is one of the best performance measures that can tell transportation agencies how well or how poorly the transportation system is functioning. Fluctuating operating speeds often mean there is a design flaw or something about the physical road design that violates drivers' expectations. A primary example of this is a horizontal curve on a highway that had a reduced recommended advisory speed. Traditionally, researchers and transportation agencies measure operating speeds along the approach tangent to a horizontal curve and at the midpoint of the curve. This thesis looks at the significance of alternate measuring locations within the curve. It also analyzes the difference between the 85th percentile maximum speed reduction and the more traditional measure of the reduction in 85th percentile speeds, which is used as an indicator of safety. / Graduation date: 2012

Part I examines the global rise of both public and private debt and its recent manifestations in the US housing bubble and the financial panic of 2007-8. A review of the most popular theories of the debt crisis is provided, including an explication of securitized banking and economic theory. The underlying condition of increasing ecological and energetic scarcity is accorded central significance in the broad trajectory of world growth and debt, Part II explicates systems theories of social order and the social significance of markets. The theories of Niklas Luhmann, Talcott Parsons, Mario Bunge, Anthony Giddens, and Jürgen Habermas are evaluated with respect to their theories of social order and crisis. A central finding is that, although declining rates of exergy production inhibit the global economic recovery as measured by conventional economic tools, this fact is not likely to be widely recognized. A central theme of Part II is how social systems handle uncertainty, risk, and to what extent complex social systems can be regulated normatively by the public sphere. As global society becomes increasingly interconnected and dependent upon the depletion of material and energy resources, the communication channels that facilitate the self-understanding of modern society at the same time proliferate, becoming increasingly disconnected and self-referential. Luhmann’s systems theory is used to explain why collective recognition and action is at once rendered more necessary and increasingly unlikely given the complexity of global society that Earth’s terrestrial stock of nonrenewable energy resources has engendered.

Die Bedeutung kognitiver Entwicklungskapazität (Plastizität) und ihrer altersabhängigen Grenzen für Theorien kognitiven Alters wird thematisiert. Für kognitive Basisprozesse wird erwartet, daß die durch Training umgesetzte Entwicklungskapazität älterer Menschen zwar ausreicht, die Ausgangsleistung junger Erwachsener zu übertreffen, daß aber aufgrund altersbedingter Grenzen der Entwicklungskapazität nur sehr wenige ältere Erwachsene das Leistungsniveau trainierter junger Erwachsener erreichen werden. Am Beispiel eines Gedächtnistrainingsprogrammes zur Erhöhung der Merkfähigkeit für Wortlisten werden zwei Forschungsstrategien vorgestellt: (a) das Training von sehr leistungsfähigen älteren Erwachsenen und (b) Längsschnitt-Einzelfall-Studien. Die experimentellen Befunde bestätigten die theoretischen Erwartungen. Zwar waren die Leistungen der besten älteren Erwachsenen etwa doppelt so hoch wie die untrainierter junger Erwachsener, aber die durch das Training aufgedeckten Altersverluste konnten auch in bis zu 75 weiteren Übungsstunden nicht behoben werden. / The relevance of developmental reserve capacity (plasticity) and associated age-related limits for theories of cognitive aging is discussed. For basic cognitive mechanisms, older adults' developmental reserve capacity is expected to be sufficient to surpass young adults' baseline performance. Aging-related limits of this reserve, however, will allow only very few older adults to achieve levels of performance characteristic of trained young adults. Two research strategies (designed to engineer a mnemonic skill for serial recall of words) are described: (a) training of positively selected, mentally very fit older adults and (b) longitudinal single case studies. Experimental results were in agreement with the theoretical expectations. The best older adults scored about twice as high as untrained young adults but even with up to 75 additional experimental sessions the age difference generated by the cognitive intervention was not overcome.

Generalised polyneuropathy (PNP) is a common cause to neurological impairment, and may be an early symptom of a severe systemic disease. One such illness is hereditary transthyretin (TTR) amyloidosis (ATTR), a progressive fatal disorder caused by a mutation on the TTR gene. More than 100 such mutations have been found worldwide, of which Val30Met is the most common neuropathic variant with initial clinical manifestations indicating small fiber impairment. Differences in onset age, penetrance and phenotypes are present between endemic areas. Liver transplantation generally slows the progress of the symptom development, especially in patients with short disease duration. Ongoing research has also shown promising results with drug interventions. In any event, early diagnosis of PNP onset in ATTR patients is crucial to ensure early therapeutic interventions. Nerve conduction studies (NCS) and electromyography (EMG) provide the basis for evaluation of the functional state of the thick myelinated nerve fibres in patients with symptoms of PNP, but no such quantitative methods are available for the thin myelinated or unmyelinated fibers. Instead, a psychophysical method with thermal quantitative sensory testing (QST) can provide indirect information about the overall function in the afferent small fiber systems. The purpose of thesis was to evaluate the applicability of QST by the Method-of-limits (MLI) for early detection of PNP in Swedish ATTR patients with the Val30Met mutation. In healthy subjects the repeatability of the MLI was assessed, and reference values for thermal perception thresholds (TPT) in several body regions were determined. No significant differences in TPT or pain thresholds were found at repeated testing with MLI, indicating that the MLI is a reliable method. However, the results show that the arrangement of the testing order is of importance, as cold (CT) and warm (WT) perception thresholds were significantly elevated when tested after thermal pain assessments, instead of before. I general, the TPT was more elevated at lower parts of the body compared to the upper part, and with higher WT than CT, fully in accordance with the underlying anatomical and physiological prerequisites for QST. In biopsy verified ATTR patients lacking EMG and NCS abnormalities, significantly elevated TPT were found compared to controls. Furthermore, significantly more increased TPT were observed in patients with an early onset of the disease, compared those with a late onset. Finally, a combined detailed evaluation of QST and heart rate variability (HRV) analyses demonstrated correlations between QST and HRV abnormalities in patients with late onset, but not in those with early onset. The present thesis emphasizes the importance of incorporating QST early in the clinical evaluation of ATTR patients with a Val30Met mutation and with symptoms of thin fiber PNP. This is particularly indicated when patients report symptoms, or show signs, of neuropathic small fiber affection, but simultaneously exhibit normal EMG and NCS findings. The results furthermore underline the importance of performing both QST and HRV for a complete evaluation of both the thin somatic and autonomic nerve fibers, as both types of nerves may be affected early in the ATTR disease.

This thesis examines the connection between technological dependence of mankind and its attitudes towards it. The issue is to what extent technological change in the workplace is a generator of conflict or a creator of consensus? The subject of the study is the Swedish mining company LKAB during the period 1946-1987. The case study concentrates on the approaches to new technology by the local union leadership and the LKAB company management. The analysis is carried out through a classification scheme over job- functions, divided into four functional categories. The classification is ranging from manually inclined work on the end to highly automized work on the other pole. The results show a clear and unquestionable development of mechanization. At the next level of analysis the focus is on approaches and ways of relating mechanization by the two parties took on the question, and how this influenced the relationships between the two parties. The final results show that technological change in general is a creator of consensus. However, at the same time, techno­logical change is an unequeal process because the company commands control over three kinds of power resources; ownership, the legislative right of paragraph 32 and the monopoly of technological expertis. Organized labour can only try to attain technological knowledge and high levels of worker support. / digitalisering@umu

Biological invasions provide opportunities to study evolutionary processes occurring during contemporary time scales. Here, I combine a literature review of common garden studies of invasive plant species, with field and glasshouse experiments on populations of the outcrossing, perennial, wetland invader Lythrum salicaria (purple loosestrife - Lythraceae), to investigate the evolutionary genetics of local adaptation in reproductive and life-history traits. A review of 32 common garden studies of 28 introduced species identified previously unrecognized latitudinal clines in phenotypic traits in both native and introduced populations. To obtain direct evidence for clinal variation and local adaptation, I investigated populations of L. salicaria sampled along a latitudinal gradient of growing season length in eastern North America. Controlled pollinations of plants from 12 populations provided no evidence for the breakdown of self-incompatibility to self-compatibility towards the northern range limit. However, a quantitative genetic experiment involving 20 populations revealed latitudinal clines in population mean, variance and skew for days to flower and vegetative size. Broad-sense estimates of genetic variance were significant for most traits; however, strong inter-correlations among traits suggested that fitness trade-offs have constrained population divergence. The observed clines supported a model of selection for early flowering in northern populations constrained by a trade-off between age and size at flowering. A comparison of variance-covariance matrices of family and population means (G and D, respectively) of life-history traits demonstrated that populations have evolved in response to selection under genetic constraints, rather than through neutral processes. A reciprocal transplant experiment involving six populations and three common gardens spanning the latitudinal range provided direct evidence for local adaptation in flowering phenology. Populations maintained the same rank-order for time to flowering and vegetative size at each site, and southern populations had the highest fecundity at the southern site but the lowest at the northern site. Finally, a phenotypic selection analysis in each common garden involving 61 F2 families of crosses between a northern × southern populations confirmed that selection favours earlier flowering in northern populations. These results demonstrate that natural selection on reproductive phenology has accompanied the invasive spread of L. salicaria in eastern N. America.

The thesis reports the results of comprehensive studies carried out to explore the impact of midpoint FACTS Controllers (STATCOM and SVC) on the generator distance phase backup protection in order to identify important issues that protection engineers need to consider when designing and setting a generator protection system. In addition, practical, feasible and simple solutions to mitigate the adverse impact of midpoint FACTS Controllers on the generator distance phase backup protection are explored. The results of these studies show that midpoint FACTS Controllers have an adverse effect on the generator distance phase backup protection. This adverse effect, which can be in the form of underreach, overreach or a time delay, varies according to the fault type, fault location and generator loading. Moreover, it has been found that the adverse effect of the midpoint FACTS Controllers extends to affect the coordination between the generator distance phase backup protection and the generator steady-state overexcited capability limit. The Support Vector Machines classification technique is proposed as a replacement for the existing generator distance phase backup protection relay in order to alleviate potential problems. It has been demonstrated that this technique is a very promising solution, as it is fast, reliable and has a high performance efficiency. This will result in enhancing the coordination between the generator phase backup protection and the generator steady-state overexcited capability limit in the presence of midpoint FACTS Controllers. The thesis also presents the results of investigations carried out to explore the impact of the generator distance phase backup protection relay on the generator overexcitation thermal capability. The results of these investigations reveal that with the relay settings according to the current standards, the generator is over-protected and the generator distance phase backup protection relay restricts the generator overexcitation thermal capability during system disturbances. This restriction does not allow the supply of the maximum reactive power of the generating unit during such events. The restriction on the generator overexcitation thermal capability caused by the generator distance phase backup protection relay highlights the necessity to revise the relay settings. The proposed solution in this thesis is to reduce the generator distance phase backup protection relay reach in order to provide secure performance during system disturbances.

Biological invasions provide opportunities to study evolutionary processes occurring during contemporary time scales. Here, I combine a literature review of common garden studies of invasive plant species, with field and glasshouse experiments on populations of the outcrossing, perennial, wetland invader Lythrum salicaria (purple loosestrife - Lythraceae), to investigate the evolutionary genetics of local adaptation in reproductive and life-history traits. A review of 32 common garden studies of 28 introduced species identified previously unrecognized latitudinal clines in phenotypic traits in both native and introduced populations. To obtain direct evidence for clinal variation and local adaptation, I investigated populations of L. salicaria sampled along a latitudinal gradient of growing season length in eastern North America. Controlled pollinations of plants from 12 populations provided no evidence for the breakdown of self-incompatibility to self-compatibility towards the northern range limit. However, a quantitative genetic experiment involving 20 populations revealed latitudinal clines in population mean, variance and skew for days to flower and vegetative size. Broad-sense estimates of genetic variance were significant for most traits; however, strong inter-correlations among traits suggested that fitness trade-offs have constrained population divergence. The observed clines supported a model of selection for early flowering in northern populations constrained by a trade-off between age and size at flowering. A comparison of variance-covariance matrices of family and population means (G and D, respectively) of life-history traits demonstrated that populations have evolved in response to selection under genetic constraints, rather than through neutral processes. A reciprocal transplant experiment involving six populations and three common gardens spanning the latitudinal range provided direct evidence for local adaptation in flowering phenology. Populations maintained the same rank-order for time to flowering and vegetative size at each site, and southern populations had the highest fecundity at the southern site but the lowest at the northern site. Finally, a phenotypic selection analysis in each common garden involving 61 F2 families of crosses between a northern × southern populations confirmed that selection favours earlier flowering in northern populations. These results demonstrate that natural selection on reproductive phenology has accompanied the invasive spread of L. salicaria in eastern N. America.

Chile and Santiago are struggling with heavy environmental problems as a consequence of urbanisation and industrialisation. In the Santiago region the air is seriously contaminated and most of the rivers are classified as heavily polluted. The aim of this thesis is to survey the industrial fluid waste situation in the Santiago region and to make suggestions on technological improvements or process changes. The purpose is also to study five different enterprises more closely and to give more detailed suggestions for improvement. Another purpose is to summarize relevant Chilean legislation. Information, provided by the supervisory authority, about the release of industrial wastewater to rivers has been analysed. Deep interviews have been made with authorities and consultants. Five enterprises have been visited; a brewery, a dairy, a bakery, a producer of cooked meat and a surface treatment industry. The present treatment of the wastewater was studied at the plants and the information was completed with a questionnaire to the responsible at each company. The contamination load released to the Chilean rivers is heavy. The rivers in southern Chile receive the biggest loads of BOD and SS and the rivers in central Chile were the most exposed to discharges of the metals Cr, Cu, Zn and CN as well as phenols. The industrial discharge into the rivers of Santiago RM and Region VII is also to a large extent characterized by high concentrations of BOD and SS. Large releases of oils and greases, nitrogen and phosphorus are also fairly common, as are too high or too low pH levels. The food industry is the most contaminating sector, but also tanneries have great problems with effluents exceeding limits. All five companies visited share the need to take measures towards more water saving technologies. The brewery, the producer of cooked meat and the surface treatment company also need end-of-pipe-treatment of their wastewater. In many cases, the recommended and most economic alternative is to separate the flows with the highest concentration of polluting substances for internal treatment, while releasing the rest of the wastewater to the outside sewage system. The costs of the suggested changes must be balanced against the present costs for treatment of wastewater and remaining solid waste as well as the costs for alternative treatments. The economic incentives for Chilean companies to invest in wastewater treatment plants or to optimize the processes until today have been few. Cost reductions may be achieved by savings in water consumption and reuse of raw material. Another motive could be to keep “one step ahead” if the discharge limits in the future are tightened up leading to rising costs. / Chile och Santiago brottas med omfattande miljöproblem till följd av urbanisering och industrialisering. I santiagoregionen är luftföroreningarna svåra och de flesta floderna klassas som gravt förorenade av CONAMA, det chilenska naturvårdsverket. Syftet med examensarbetet är att kartlägga situationen i santiagoregionen med avseende på industriell avloppsrening samt att ge förslag på förbättring av teknik eller förändring av processer. Dessutom är syftet att studera fem industrier närmare och att ge mer detaljerade förslag på åtgärder. Syftet är också att ge rekommendationer för fortsatt utveckling av relevant chilensk lagstiftning. Uppgifter från tillsynsmyndigheten för utsläpp till ytvattendrag har studerats och djupintervjuer har gjorts med myndigheter och konsulter. Fem olika industrier besöktes; ett bryggeri, ett mejeri, ett bageri, ett charkuteri samt en ytbehandlingsindustri. Nuvarande hantering av processvattnet studerades på plats och med hjälp av ett frågeformulär kompletterades uppgifterna av ansvariga på företagen. Föroreningsbelastningen på Chiles floder är stor. Floderna i södra delen av landet tar emot störst mängder organiskt material och suspenderat material medan centrala Chiles floder är värst drabbade av utsläpp av metallerna Cr, Cu, Zn och CN samt utsläpp av fenoler. Utsläppen från industrin till floderna i Region Metropolitana och Region VII kännetecknas också i stor utsträckning av höga halter BOD och suspenderat material. Relativt vanligt är också stora utsläpp av oljor och fetter, kväve, fosfor samt för höga eller låga för pH-värden. Det är främst flera olika typer av livsmedelsindustri, som har de största utsläppen till floderna, men även garverierna har stora problem med överskridande av gränsvärden. Gemensamt för de fem besökta företagen är att vattenbesparande åtgärder bör vidtas för att minska volymen avloppsvatten som går till extern eller intern behandling. Bryggeriet, charkuterifabriken och ytbehandlaren behöver även end-of-pipe-rening. Det kan ofta vara lämpligt och mer ekonomiskt att avskilja de flöden som har högst halt av föroreningar till den interna reningsanläggningen. Resten av avloppet kan i vissa fall släppas ut på avloppsnätet. Kostnader för föreslagna åtgärder måste vägas mot aktuella kostnader för behandling av avlopp och restprodukter, samt kostnader för alternativa behandlingar. Incitamenten, bl a de ekonomiska, för chilenska företag att skaffa eget reningsverk eller att resurseffektivisera produktionen har hittills varit små. Kostnadsminskningar kan uppnås genom sänkt vattenförbrukning samt återanvändning av råmaterial. Ytterligare en drivkraft kan vara att ”ligga steget före” om utsläppskraven i framtiden skärps och kostnaderna därmed ökar.