Thesis (doctoral)--Lund University, 1994. / Added t.p. with thesis statement inserted.

The suckling rat has provided a useful model for these studies of lipid digestion and absorption. In adults dietary triacylglycerols are predominantly hydrolyzed by the "classic" mechanism involving pancreatic lipase (E.C. 3.1.1.3) and biliary micelle-mediated product uptake. Unlike affluent man, adult laboratory rats normally consume a low-fat diet (< 20% of energy). However suckling rats, like most neonates, consume a milk diet that is normally high in fat. Suckling rats receive ~90% of non-protein energy from milk triacylglycerols, although rats have very low levels of "classic" pancreatic lipase before weaning. Dissertation studies demonstrate that other lipases promote efficient gastrointestinal triacylglycerol utilization in suckling rats. Nearly half of milk triacylglycerols are hydrolyzed to diacylglycerol within the stomach; and results strongly support that lingual lipase is the significant source of this activity. Furthermore, enzyme studies show considerable similarity between this lipase from rat tongue and so-called pregastric esterases of suckling ruminant species. Of fatty acids released in stomach, nearly three-quarters are of medium-chain length. These have high aqueous solubility and are rapidly absorbed from the upper gastrointestinal tract. Remaining triacylglycerols, diacylglycerols, and long-chain fatty acids enter the intestinal lumen and mix with lipid-rich bile. Suckling rats have higher biliary concentrations of bile salts, phospholipids and cholesterol than do adults. Bile salt enterohepatic circulation clearly occurs in the suckling rat, at least as early as 10 days. The bile acid β-muricholate is elevated during the suckling period, compared to post-weaning. Results show that further lipolysis occurs along the intestine, possibly through the action of lingual lipase and others from pancreas, producing mostly long-chain free fatty acids, monoacylglycerol, and some lysophosphatidylcholine, derived largely from bile. This composition closely resembles adult intestinal contents, but is much higher in both dietary and biliary lipid constituents. Alteration of milk triacylglycerol fatty acids produced no apparent impairment in gastrointestinal lipid utilization by sucklings, but resulted in hyperlipemia and increased carcass fatness. These results suggest gastrointestinal events do not limit triacylglycerol utilization in the suckling rat, regardless of composition; but post-absorptive metabolism may be different when sucklings consume altered milk lipids.

Thesis (M. Med. Sc.)--University of Hong Kong, 2007.

Thesis (Ph. D.)--University of Oregon, 2007. / Typescript. Includes vita and abstract. Includes bibliographical references (leaves 195-207). Also available for download via the World Wide Web; free to University of Oregon users.

Thesis (Ph. D.)--University of Wisconsin, 1955. / Typescript. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references (leaves [72]-79).

Thesis (Ph. D.)--University of Wisconsin--Madison, 1944. / Typescript. Vita. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references (leaves 31-36).

Thesis (M.Sc.)--Memorial University of Newfoundland, 1999. / Restricted until June 2000. Bibliography: leaves [117]-132.

Thesis (doctoral)--Lund University, 1996. / Added t.p. with thesis statement inserted.

Thesis (doctoral)--Lund University, 1996. / Added t.p. with thesis statement inserted.

Fifty-seven subjects from 14 families participated in a study designed to investigate similarities and differences between parents and children residing with them relative to their serum lipid levels and dietary lipid intakes. To participate, at least one of the parents needed to have a serum total cholesterol of at least 240 mg/dL. Fasting blood samples obtained from the participants were analyzed for serum total cholesterol, HDL-C, LDL-C, and VLDL-C levels. Anthropometric measurements and blood pressure readings also were taken. Dietary records, questionnaires on lifestyle, health habits, health history, and nutrition knowledge were completed by the participants. Correlation coefficients between serum total cholesterol and dietary cholesterol intakes of the fathers were 0.66 (p = 0.01) in all 14 families and 0.64 (p = 0.05) in the 11 families in which at least one parent had a family history of CHD. The values of the correlation coefficients of HDL-C and the intake of dietary cholesterol of the children for the 14 families and the 11 families were -0.36 (p = 0.07) and -0.55 (p = 0.01) respectively. A significant correlation was found between the dietary pattern of the parents and that of their children. The following correlation coefficients were found for the five families in which both parents had a fmaily history of CHD: 0.65 (p = 0.02) for total fat, 0.79 (p = 0.002) for saturated fat , and 0.59 (p = 0.04) for cholesterol. / Master of Science