Abstract Laboratory animals play an essential role to level up medical research, life science and biotechnology. On the other hand, animal quality and supply would directly influence the result of research. Since 1940, western countries has been developing the laboratory animal science, and 1990 western countries start to develop biotechnology industry, until 2000, has tremendous growth, especially the human genomic sequence was completed causing the demand of disease model animals increasing and also speed up the development of biotechnology industry. Regarding the biotechnology industry in Taiwan, started in 2000 and has very limit development for laboratory animal industry become an obstacle of biotechnology industry developing. Therefore, it can¡¦t be ignored that laboratory animal industry leveling up and future developing strategy has a high tribute to Taiwan biotechnology. As case study, we got an approval to review two companies how to improve and maintain their competitive advantages through managing process. These two companies are 1) Charles River Laboratories who has more than 50years history and is the largest global laboratory animal supply company; 2) BioLasco Taiwan who is the only one private company in Taiwan producing SPF Rodents. Through Michael Porter¡¦s 5 competitive forces and SWOT together with two companies developing strategies as references of the future development strategy models for government policy making and also for private enterprise who are interested in involving in this industry. The results of this study provides the key developing strategies for Taiwan laboratory animal industry as following aspects: (1) Market globalization : Regionalized marketing and production for SPF laboratory animals and model animals to meet the economy scale in order to reduce the cost and to get more benefits. (2) The diversification of products and services: Excluding laboratory animal supply, breeding equipments production management of animal housing and outsourcing service forming multiple product lines to enhance the industrious competitiveness and expand market potential for risk sharing sake. (3)R&D and talent internationalization: Through national innovation system and human resource integrated, accompany with NIH. Jackson Lab. and other international/ domestic research institutes together developing new products and new technologies to boast the global competitiveness and competitive advantage for Taiwan laboratory animal industry.