Thesis (M.S.)--University of Adelaide, Dept. of Surgery, 1999? / Bibliography: leaves 143-165.

Copies of author's previously published articles enclosed. Bibliography: leaves 217-258. Examines recent literature which describes cases of metastatic involvement of laparoscopic port sites, not only in patients with advanced tumors but in patients with early stage carcinoma, and even in patients following laparoscopic procedures during which tumors were not disturbed. This thesis utilises an established small animal model to investigate the aetiology of port site metasrases and the efficacy of preventative strategies in reducing tumor implantation following laparoscopy.

The purpose of this study is to determine if early laparoscopic cholecystectomy in patients with uncomplicated gallstone disease and symptoms of dyspepsia will produce complete symptomatic resolution 1 year postoperatively and to identify appropriate timing of laparoscopic cholecystectomy to decrease cholecystectomy failure rate. Specific research objectives were to determine: <p>1) if laparoscopic cholecystectomy in patients with gallstones and symptoms of dyspepsia will achieve complete symptomatic relief; <p>2) the change in the preoperative score to the postoperative score and satisfaction after laparoscopic cholecystectomy for the two groups: patients with gallstones and symptoms of dyspepsia and the patients with gallstones and no dyspepsia; <p>3) the relationship between the duration of preoperative episodes and the probability of complete resolution of symptoms with laparoscopic cholecystectomy in patients with gallstones and symptoms of dyspepsia; <p>4) the relationship between the frequency of preoperative episodes and the probability of complete resolution of symptoms with early laparoscopic cholecystectomy in patients with gallstones and symptoms of dyspepsia and <p>5) the differences in pathologic findings between patients with gallstones and no symptoms of dyspepsia versus patients with symptoms of dyspepsia.<p>The methods included a retrospective chart review for patient identification, a follow up survey and microscopic pathological examination of gallbladder specimens. Nine hundred and forty two patients entered the study. Three hundred and fifty nine surveys were returned producing a response rate of 43%. Two hundred and sixty four patients (77.0%) had symptoms of dyspepsia (Group I) and 79 patients (23.0%) had no symptoms of dyspepsia (Group II). <p>Laparoscopic cholecystectomy for patients with gallstones and symptoms of dyspepsia does not achieve complete symptomatic relief 1 year after surgery. The frequency and duration of preoperative episodes have no relation to the outcome of surgery. The majority of patients in both Groups (I, II) were found to have morphological evidence of acute cholecystitis and only a small number had chronic cholecystitis. Group I had a greater reduction in the Buckley score than Group II after LC but had similar rates of satisfaction from surgery.

Previous studies have shown that not all surgical residents can acquire the required skills for performing laparoscopic surgery. Therefore, the training methods can be improved to accommodate trainees with different psychomotor abilities. The first step towards improving training methods is understanding the brain function in performing the laparoscopic surgery training tasks, which can be facilitated by neuroimaging methods such as functional magnetic resonance imaging (fMRI). In this study, a laparoscopic surgery training box for use in fMRI was developed. Experiments confirmed the fMRI-compatibility of the device. Nine right-handed subjects underwent fMRI while performing the surgical training tasks after ten practice sessions in a simulated fMRI environment. Behavioural and fMRI results confirmed the feasibility of using this simulator and revealed the neuroanatomical correlates associated with performing the training tasks. Accordingly, this study may facilitate the evidence-based development of strategies to improve the quality of laparoscopy training and assessment strategies.

Previous studies have shown that not all surgical residents can acquire the required skills for performing laparoscopic surgery. Therefore, the training methods can be improved to accommodate trainees with different psychomotor abilities. The first step towards improving training methods is understanding the brain function in performing the laparoscopic surgery training tasks, which can be facilitated by neuroimaging methods such as functional magnetic resonance imaging (fMRI). In this study, a laparoscopic surgery training box for use in fMRI was developed. Experiments confirmed the fMRI-compatibility of the device. Nine right-handed subjects underwent fMRI while performing the surgical training tasks after ten practice sessions in a simulated fMRI environment. Behavioural and fMRI results confirmed the feasibility of using this simulator and revealed the neuroanatomical correlates associated with performing the training tasks. Accordingly, this study may facilitate the evidence-based development of strategies to improve the quality of laparoscopy training and assessment strategies.

The purpose of this study is to determine if early laparoscopic cholecystectomy in patients with uncomplicated gallstone disease and symptoms of dyspepsia will produce complete symptomatic resolution 1 year postoperatively and to identify appropriate timing of laparoscopic cholecystectomy to decrease cholecystectomy failure rate. Specific research objectives were to determine: <p>1) if laparoscopic cholecystectomy in patients with gallstones and symptoms of dyspepsia will achieve complete symptomatic relief; <p>2) the change in the preoperative score to the postoperative score and satisfaction after laparoscopic cholecystectomy for the two groups: patients with gallstones and symptoms of dyspepsia and the patients with gallstones and no dyspepsia; <p>3) the relationship between the duration of preoperative episodes and the probability of complete resolution of symptoms with laparoscopic cholecystectomy in patients with gallstones and symptoms of dyspepsia; <p>4) the relationship between the frequency of preoperative episodes and the probability of complete resolution of symptoms with early laparoscopic cholecystectomy in patients with gallstones and symptoms of dyspepsia and <p>5) the differences in pathologic findings between patients with gallstones and no symptoms of dyspepsia versus patients with symptoms of dyspepsia.<p>The methods included a retrospective chart review for patient identification, a follow up survey and microscopic pathological examination of gallbladder specimens. Nine hundred and forty two patients entered the study. Three hundred and fifty nine surveys were returned producing a response rate of 43%. Two hundred and sixty four patients (77.0%) had symptoms of dyspepsia (Group I) and 79 patients (23.0%) had no symptoms of dyspepsia (Group II). <p>Laparoscopic cholecystectomy for patients with gallstones and symptoms of dyspepsia does not achieve complete symptomatic relief 1 year after surgery. The frequency and duration of preoperative episodes have no relation to the outcome of surgery. The majority of patients in both Groups (I, II) were found to have morphological evidence of acute cholecystitis and only a small number had chronic cholecystitis. Group I had a greater reduction in the Buckley score than Group II after LC but had similar rates of satisfaction from surgery.

Thesis (M.Sc.)--York University, 2008. Graduate Programme in Biology. / Typescript. Includes bibliographical references (leaves 54-57). Also available on the Internet. MODE OF ACCESS via web browser by entering the following URL: http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pqdiss&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&rft_dat=xri:pqdiss:MR45974

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Copies of the just first page of author's previously published articles inserted. / Bibliography: leaves 227-254. / xix, 256 leaves : ill. ; 30 cm. / Title page, contents and abstract only. The complete thesis in print form is available from the University Library. / Supports the routine application of laparoscopic techniques to antireflux surgery, but not the routine division of the short gastric vessels during Nissen fundoplication. / Thesis (M.D.)--University of Adelaide, Dept. of Surgery, 1998