This investigation attempted to determine the relationship of the site of contact ulcers and subject’s handedness. Literature concerned with contact ulcers has indicated that cerebral dominance tends to determine the site of the lesion. Four research questions were posed, two questions were presented in the form of the null hypothesis. The questions were: (1) Is the proportion of right-handed subjects with left-sided ulcers equal to the proportion of left-handed subjects with left-sided ulcers? (2) Is the proportion of right-handed subjects with right-sided ulcers equal to the proportion of left-handed subjects with right-sided ulcers? (3) Will the site of contact ulcers be able to be predicted from subject’s handedness? And (4) Is there a significant relationship between the factors of age, sex and occupation of the sample studied and the occurrence of contact ulcers?