Spelling suggestions: "subject:"laulimalide"" "subject:"laulimalides""
1 |
Synthetic Studies of Laulimalide AnaloguesMcAlexander, Ian Addison 01 May 2009 (has links)
Chapter 1 provides some background information on the disease area of cancer and current modes of treatment. Chemotherapy treatment is discussed with a focus on the major cellular targets for these drugs: DNA and microtubules. For each target, classes of active compounds are described along with their mode of action. The microtubule stabilizing agent laulimalide is introduced and a case is made for analogue synthesis.
Chapter 2 describes our first generation efforts toward synthesis of des-methyl laulimalide. The target compound is divided into a northern and southern fragment with the synthesis of each fragment described. The preparation of landmark intermediates along the synthetic route is also described.
Chapter 3 presents our ongoing efforts toward a second generation synthesis of des-methyl laulimalide. Our progress toward a des-methyl,des-pyran analogue is covered as well.
Chapter 4 reviews progress in the area of laulimalide analogue development. Biological assay results and the first insights into structure-activity-relationships are described.
|
2 |
Part I. Studies towards a total synthesis of laulimalide Part II. Studies on the detection of levuglandinsSingh, Upinder January 1994 (has links)
No description available.
|
3 |
Host/guest chemistry: from rings and metals to proteins and drugsGajewski, Melissa May Unknown Date
No description available.
|
Page generated in 0.0323 seconds