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Bibliography: leaves 246-304. Describes experiments aimed at characterising the potential virilant factors of Legionella longbeachae sg 1, an important human pathogen which is responsible for nearly half of all clinical cases of Legionella related pneumonia reported each year.

Bibliography: leaves 246-304. / xi, 304, [43] leaves, [35] leaves of plates : ill. (some col.) ; 30 cm. / Title page, contents and abstract only. The complete thesis in print form is available from the University Library. / Describes experiments aimed at characterising the potential virilant factors of Legionella longbeachae sg 1, an important human pathogen which is responsible for nearly half of all clinical cases of Legionella related pneumonia reported each year. / Thesis (Ph.D.)--University of Adelaide, Dept. of Microbiology and Immunology, 2000

Thesis (Ph.D.) -- University of Adelaide, Dept. of Microbiology and Immunology, 2000. / Bibliography: leaves 246-304.

A prospective study of patients with pneumonia admitted to Groote Schuur Hospital took place over a one-year period in an attempt to assess the incidence of legionella pneumonia. Acute and convalescent serum samples were obtained from 113 patients. Eight patients (7,1%) showed a fourfold rise in antibody titre against Legionella pneumophila group 1 antigen by indirect immunofluorescent test (IFAT). The findings suggest that legionella pneumonia, although not common, should be considered in the aetiology of pneumonia at Groote Schuur Hospital. The results are presented and a review of the literature is undertaken.

Thesis (M.SIS)--University of Adelaide, Dept. of Geographical and Environmental Studies and GISCA - The National Key Centre for Social Applications of GIS, 2000. / Includes bibliographical references (leaves 115-120).

A virulent strain of Legionella pneumophila serogroup 1 was established in continuous culture under defined iron-replete conditions at pH 6.9. Iron-limitation and extremes of pH (6.0 and 7.8) influenced the growth and metabolism of L. pneumophila, as manifested by increased metabolic activity, impaired energy coupling, and altered metabolic fluxes. In particular, the physiological versatility of L. pneumophila was demonstrated by a significant decrease in the iron content of biomass (6-fold increase in Yiron), coupled with reduced metabolic efficiency (Y, on), in response to iron-limited growth. Iron limitation promoted the accumulation of significant intracellular reserves of poly- ß-hydroxybutyrate (16 % cell dry wt.), which supported long-term survival of L. pneumophila under starvation conditions. Expression of the important pathogenicity factor, the zinc metalloprotease, was regulated by iron availability. Common iron acquisition mechanisms, such as siderophores and transferrin receptors, were not elaborated by iron-limited cells. However, human transferrin was identified as a potential iron source for L. pneumophila, with the zinc metalloprotease mediating transferrin digestion and possibly iron acquisition. Iron-limitation and extremes of pH also influenced cellular morphology and the surface properties of L. pneumophila, promoting the formation of uniform cultures of short rod-shaped bacteria, with altered fatty acid, phospholipid and protein composition. In addition to morphological and physiological adaptation, iron limitation had a significant effect on the virulence of L. pneumophila. Iron-replete cells grown at pH 6.9 and 6.0 were highly virulent in a guinea pig model. However, the virulence of L. pneumophila was significantly attenuated (P < 0.05) in response to iron-limited growth. This phenomenon was reversible, and correlated with reduced phagocytosis and / or reduced intracellular survival following infection. Decreasing the pH of iron-limited cultures to 6.0 did not stimulate recovery of culture virulence. Therefore, this study clearly demonstrates that environmental stresses, including iron limitation and extremes of pH, play an important role in modulating the physiology and virulence of L. pneumophila, inducing the expression of distinct phenotypes differing in their ability to persist in nature and cause infection.

Thesis (M.Sc. (Clinical Pathology))--Mahidol University, 1984.

The thesis analyses the role of legionaries who served in the gendarmerie corps and in the context of the First Republic era. The timeframe of the thesis is defined from the establishment of the Republic in 1918, respectively from the beginning of the recruitment of the first legionaries to the Gendarmerie Corps, until the end of the First Republic, with the addition of an outline of the situation in the Protectorate. Research questions include whether state- guaranteed benefits were applied in practice. Whether the legionary background helped gendarmes to advance in their careers and, last but not least, whether their service differed from that of other gendarmes (e.g., in the form of exemptions). Attention will be paid to the evaluation of the performance of legionary gendarmes by their commanders and subsequent comparison with the performance of other gendarmes. Time-wise, the thesis is divided into three blocks, according to the relevance to the phenomenon. In order to answer these questions, primary sources were worked with, especially the fonds of the General Commander of the Gendarmerie in the National Archives. In addition, sources stored in the Military Central Archive and the archives of the Ministry of the Interior were used. Secondary literature on the subject is, with few exceptions,...