• Refine Query
  • Source
  • Publication year
  • to
  • Language
  • 1
  • Tagged with
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
1

Modelo Experimental de Radiodermatite em Coelhos / Experimental model of radiodermatitis in rabbits

Meirelles, Rafael Panisi de Campos [UNIFESP] January 2015 (has links) (PDF)
Submitted by Maria Anália Conceição (marianaliaconceicao@gmail.com) on 2016-06-28T13:08:11Z No. of bitstreams: 1 Publico-NOVO-24.pdf: 1515165 bytes, checksum: 3b9206d6518639a99202f8ee9c5f29ad (MD5) / Approved for entry into archive by Maria Anália Conceição (marianaliaconceicao@gmail.com) on 2016-06-28T13:15:12Z (GMT) No. of bitstreams: 1 Publico-NOVO-24.pdf: 1515165 bytes, checksum: 3b9206d6518639a99202f8ee9c5f29ad (MD5) / Made available in DSpace on 2016-06-28T13:15:12Z (GMT). No. of bitstreams: 1 Publico-NOVO-24.pdf: 1515165 bytes, checksum: 3b9206d6518639a99202f8ee9c5f29ad (MD5) Previous issue date: 2015 / Introdução: A tolerância cutânea à radiação é o principal fator limitante da radioterapia. A escassez de estudos experimentais é imensa, principalmente em animais de médio porte, como os coelhos. Objetivo: Descrever um modelo experimental de radiodermatite em coelhos Métodos: Neste estudo foram utilizados 24 coelhos da raça Nova Zelândia, machos, com 6 meses de idade, peso médio de 2,5 Kg. Os mesmos foram distribuídos em 4 grupos (n=6 para cada grupo), sendo um grupo controle (sem nenhuma intervenção) e os demais submetidos à radioterapia com sessão única de 10, 20 e 30 Gy, respectivamente. Foram realizadas análises fotográficas e histopatológicas das áreas irradiadas. Resultados: Os animais do grupo controle após 30 dias da epilação apresentaram crescimento dos fâneros regularmente. Os animais do grupo 20 Gy e 30 Gy apresentaram alopecia com duração de 60 dias e 90 dias, respectivamente. A partir do dia 30, a área irradiada dos animais do grupo 30 Gy apresentou grau 3 e 4 de radiodermatite, persistindo por 90 dias. A redução progressiva da contagem de anexos, vasos sanguíneos e um aumento da deposição de colágeno foi significante, quando comparado o o grupo controle com o grupo de 30 Gy. Conclusão: A dosagem de 30 Gy é a mais eficaz para este modelo experimental de radiodermatite. / Introduction: The cutaneous tolerance is a limiting factor for this oncologic treatment. The lack of experimental models is enormous, primarily for mid size animals, such as rabbits. Purpose: Describe an experimental model of cutaneous radiation injury in rabbits Methods: On this study 24 six-month-old New Zealand male rabbits, with an average weight of 2.5kg, were used. They were distributed in 4 groups (n=6 per group). The control group did not receive radiotherapy and the others received one radiotherapy session of 10, 20 and 30Gy, respectively. Photographic analysis and histopathological evaluation of the irradiated areas were carried out. Results: After 30 days, the animals from the control group had all their hair grown. In spite of that, the animals from group 20Gy had a 60-day alopecia and from group 30Gy, a 90-day alopecia. After the 30th day, the 30Gy group demonstrated 90-day cutaneous radiation injuries, graded 3 and 4. A progressive reduction of glands and blood vessels count and an increase on collagen deposition was significant, when the control group is compared to the group 30Gy. Conclusion: This study demonstrates the dosage 30Gy is the most effective for this experimental model of cutaneous radiation injury in rabbits.

Page generated in 0.1649 seconds