Thesis (MMedVet. (Companion Animal Clinical Studies))--University of Pretoria, 2007. / Includes bibliographical references. Also available in print format.

Inaug.--diss--Leipzig. / Lebenslauf. At head of title: Aus dem veterinärinstitut der Universität Leipzig. "Sonderabdruck aus dem Archiv f. wissensch. u. prakt. tierheilkunde. bd. 33. 1907." Literatur: p. 44-47.

No description available.

No description available.

Background: Lung cancer causes more deaths than any other cancer. Smoking causes roughly 90% of lung cancer cases. Concurrent chemoradiation therapy is the standard of care for stage IIIb patients with performance status (PS) 0-1. A less toxic approach is warranted for less fit patients. To optimize care, the understanding of common clinical variables such as haematological responses to inflammation could be much improved. Adherence to guidelines for proper clinical work-up is vital to ensure patients’ optimal care, especially for predictive assays. Screening of high-risk patients is now being implemented internationally. Chronic pulmonary obstructive disease (COPD) patients, a group at high risk to develop lung cancer, could be of interest for screening. Methods: Patient cohorts collected nationally and regionally by manual search in patient records or automated search in electronic patient records and national registries were analysed in relation to overall survival, comorbidities, medication, treatment, smoking status, biomarkers and adherence to guidelines. Standard statistics were applied to adjust for confounding factors. Results: Induction chemotherapy results in longer overall survival than radiotherapy alone (15.6 and 11.6 months respectively). The overall survival for patients with combined anaemia, leucocytosis and thrombocytosis at diagnosis is half of what could be anticipated if blood samples are normal (8.0 and 16.0 months respectively). Fifty percent of patients were overlooked in the routine work-up with EGFR analysis. Less than 40% of the patients received EGFR-tyrosine kinase inhibitors in first-line therapy. The frequency of EGFR mutation was 9.9%. COPD patients with asthma and medicating with inhaled corticosteroids, specific serotonin reuptake inhibitors (SSRI) or beta-blockers have a significantly decreased risk of lung cancer. Conclusions: Patients unfit to receive chemoradiation therapy should be considered for induction chemotherapy sequentially to radiotherapy. A patient that presents with pathological blood samples is likely to have poor prognosis and diagnostic work-up should be thorough to optimize outcome. Inadequate adherence to the national guidelines regarding treatment and EGFR analysis was shown. COPD patients medicating with ICS, beta-blockers or SSRI and with a concurrent asthma diagnosis have a decreased risk of lung cancer.

Foram selecionados 231 indivíduos, no período de abril de 1997 a janeiro de 1998, divididos em dois grupos controle com 88 indivíduos e 143 pacientes com doença arterial coronária. Os pacientes foram subdivididos em dois grupos: 59 com angina estável e 84 com IAM. Foram analisadas as características clínicas, fatores de risco, pressão arterial sistólica e diastólica, perfil lipídico, glicemia, tabagismo, apoliproteína Al, apoliproteína B, lipoproteína (a), fibrinogênio, ácido úrico e hemograma completo. Análise multivariada mostrou que a idade, o HDL-colesterol, leucócitos e monócitos foram fatores de risco independentes para doença arterial coronária. / Between april 1997 and january 1998, 231 patients were selected and divided into two groups: control group with 88 patients and 143 patients with coronary artery disease. The latter group was then divided into two subgroups: 59 patients with stable angina and 84 patients with AMI. Clinical characteristics, risk factors, systolic and diastolic blood pressure, lipid profile, glycemia, smoking, apoliprotein Al, apoliprotein B, lipoprotein(a), fibrinogen, uric acid and total blood cell count were analyzed. Multivariate analysis showed age, HDL-cholesterol, leukocytes and monocytes as independent risk factors for coronay heart disease.

Foram selecionados 231 indivíduos, no período de abril de 1997 a janeiro de 1998, divididos em dois grupos controle com 88 indivíduos e 143 pacientes com doença arterial coronária. Os pacientes foram subdivididos em dois grupos: 59 com angina estável e 84 com IAM. Foram analisadas as características clínicas, fatores de risco, pressão arterial sistólica e diastólica, perfil lipídico, glicemia, tabagismo, apoliproteína Al, apoliproteína B, lipoproteína (a), fibrinogênio, ácido úrico e hemograma completo. Análise multivariada mostrou que a idade, o HDL-colesterol, leucócitos e monócitos foram fatores de risco independentes para doença arterial coronária. / Between april 1997 and january 1998, 231 patients were selected and divided into two groups: control group with 88 patients and 143 patients with coronary artery disease. The latter group was then divided into two subgroups: 59 patients with stable angina and 84 patients with AMI. Clinical characteristics, risk factors, systolic and diastolic blood pressure, lipid profile, glycemia, smoking, apoliprotein Al, apoliprotein B, lipoprotein(a), fibrinogen, uric acid and total blood cell count were analyzed. Multivariate analysis showed age, HDL-cholesterol, leukocytes and monocytes as independent risk factors for coronay heart disease.